“…Selenium compounds have demonstrated high reactivity towards MPO-derived oxidants, with rate constants that are greater than those reported for the analogous sulfur containing compounds [23,24,26]. For example, selenomethionine (SeMet) and 1,4-anhydro-4-seleno-D-talitol (SeTal) react with HOCl with second-order rate constants >10 8 M -1 s -1 , comparable to the second-order rate constants for reaction of HOCl with GSH and Cys [7,27]. In addition, ebselen and SeMet, both selenoethers, have demonstrated ability to detoxify peroxides and peroxynitrous acid, forming an oxidized 7 selenium compound, which can be reduced by GSH, giving a catalytic scavenging cycle analogous to that of glutathione peroxidase (GPx) [28][29][30].…”