Reference Values for the Diffusing Capacity Determined by the Single-Breath Technique at Different Altitudes: The Latin American Single-Breath Diffusing Capacity Reference Project

Vázquez-García, Juan Carlos; Pérez‐Padilla, Rogelio; Casas, Alejandro; Schönffeldt-Guerrero, Patricia; Pereira, Jonatan; Vargas-Domínguez, Claudia; Velázquez-Uncal, Mónica; Martínez-Briseño, David; Torre-Bouscoulet, Luis; Gochicoa‐Rangel, Laura

doi:10.4187/respcare.04590

Cited by 25 publications

(15 citation statements)

References 20 publications

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“…In a study performed in 4 cities in Latin America, the altitude has influenced DCO measures, with higher values observed in the cities of Mexico (2240m) and Bogota (2640 m) in comparison with the ones observed in Santiago (650m) and Caracas (900m). (20) In this study, the altitude of the evaluated sites varied from 8 m (Salvador) to 852 m (Belo-Horizonte). When the several altitudes were included in the analyses for DCO prediction in this study, they did not havesignificant influence.…”

Section: Discussionmentioning

confidence: 99%

Valores de referência para a difusão do monóxido de carbono (fator de transferência) em uma amostra brasileira da raça branca

et al. 2019

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RESUMO Objetivo Derivar valores de referência em adultos brancos para a difusão do monóxido de carbono (DCO) em uma amostra de diferentes locais do Brasil por um mesmo modelo de equipamento (Sensormedics) e comparar os resultados com os derivados pelas equações de Crapo, Miller e Neder, e da proposta pelo Global Lung Initiative (GLI). Métodos Os testes foram realizados de acordo com as normas sugeridas pela ATS/ERS, em 2005, em seis cidades brasileiras, em 120 voluntários adultos de cada sexo, não fumantes, sem anemia referida e sem doenças pulmonares ou cardíacas. Os previstos foram derivados por regressões lineares e as diferenças entre os valores previstos por alguns autores e os observados no estudo atual foram calculadas. Resultados Nos homens, a idade variou de 25 a 88 anos e a estatura, de 156 a 189 cm. Nas mulheres, a idade variou de 21 a 92 anos e a estatura, de 140 a 176 cm. A DCO se correlacionou de maneira significativa positivamente com a estatura e negativamente com a idade. Os valores previstos pelas equações de Crapo, Neder e Miller foram maiores em comparação aos obtidos pelo estudo atual (p<0,01) em ambos os sexos. Nos homens, os valores não diferiram quando comparados aos calculados pelo GLI (p=0,29); nas mulheres, os valores derivados pelo GLI foram levemente maiores: 0,99 mL/min/mmHg (p<0,01). Conclusões Novos valores previstos para a DCO foram derivados em uma amostra de adultos brancos no Brasil. Os valores previstos são semelhantes aos compilados pelas equações GLI e diferem de equações propostas anteriormente.

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Section: Discussionmentioning

confidence: 99%

Valores de referência para a difusão do monóxido de carbono (fator de transferência) em uma amostra brasileira da raça branca

et al. 2019

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“…At least two technically acceptable maneuvers of A or B grade quality were completed, in order to reach two DLCO sb within 2 mL/min/mmHg of each other for repeatability criteria. Reference values used for this study were NHANES III for spirometry 18 , Quanjer’s for plethysmography 19 and Vazquez’s for DLCO 20…”

Section: Methodsmentioning

confidence: 99%

Comparing a new device to measure lung volumes with three traditional methods in individuals with different lung conditions

Pérez‐Padilla

et al. 2021

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Background: Lung volumes can be measured by body plethysmography (BP), by inert gas dilution during a single-breath or multiple breaths and by radiographic methods based on chest roentgenogram or CT scanning. Our objective was to analyze the concordance between several methods including a new instrument in a variety of pulmonary conditions. Methods: We recruited four groups of adult volunteers at the COPD and Tobacco Clinic of a respiratory referral hospital: patients with lung bullae, with obstructive lung diseases, with restrictive lung diseases and healthy controls; all subjects underwent lung volume measurements according to ATS/ERS standards in random order with each method and then CT scanning. Differences among groups were estimated by Kruskal-Wallis tests. Concordance correlation coefficients (CCC) and Bland-Altman plots were performed. Results: Sixty-two patients were studied including 15 with lung bullae, 14 with obstructive lung diseases, 12 with restrictive lung disease and 21 healthy subjects. Highest concordance was obtained between BP and CT scanning (CCC 0.95, mean difference -0.35 L) and the lowest, with TLC-DLCOsb (CCC 0.65, difference -1.05 L). TLC measured by BP had a moderate concordance with Minibox (CCC=0.91, mean difference -0.19 L). Minibox, on the other hand had the lowest intratest repeatibility (2.7%) of all tested methods. Conclusions: Lung volumes measured by BP and CT had a substantial concordance in the scenario of varied pulmonary conditions including lung bullae and restrictive and obstructive diseases. The new minibox device, had low intratest variability, and was easy to perform, with a reasonable concordance with BP.

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“…Spirometry and measurements of DLCO, were performed approximately four weeks following baseline symptoms through standard equipment (Easy One Pro Ò , NDD Medical Technologies, Switzerland). Spirometry reference equations were obtained from Hankinson (1999) [32]. The technical quality of spirometry was adhered to per 2019 spirometry standards [33].…”

Section: Methodsmentioning

confidence: 99%

Clinical Predictors of Lung Function in Patients Recovering from Mild COVID-19

Cortés-Télles

Figueroa‐Hurtado

Ortíz‐Farias

et al. 2021

Preprint

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Background: There are few studies have assessed lung function in Hispanic subjects recovering from mild COVID-19. Therefore, we examined the prevalence of impaired pulmonary diffusing capacity for carbon monoxide (DLCO) as defined by values below the lower limit of normal (< LLN, < 5th percentile) in Hispanics recovering from mild COVID-19. We also examined the prevalence of a restrictive spirometric pattern as defined by the ratio of forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) being ≥ LLN with the FVC being < LLN. Finally, we wanted to examine factors that cause the prevalence of an impaired DLCO to vary between studies.Methods: In this observational study, adult patients (n = 146) with mild COVID-19 were recruited from a Long-term follow-up COVID-19 clinic in Yucatan, Mexico between March, and August 2021. Spirometry, DLCO, and self-reported signs/symptoms were recorded 34 ± 4 days after diagnosis. Results: At post-evaluation, 20% and 30% patients recovering from COVID-19 were classified as having a restrictive spirometric pattern and impaired DLCO, respectively; 13% had both. The most prevalent reported symptoms were fatigue (73%), persistent cough (43%), shortness of breath (42%) and a blocked/runny nose (36%). Increased age, a blocked/runny nose, excessive night sweats, and a restrictive spirometric pattern increased probability of having an impaired DLCO. The proportion of patients with previous mild COVID-19 who had impaired DLCO increased by 12% when the definition of impaired DLCO was < 80% predicted instead of < LLN. Having severe (compared to mild) COVID-19 increased the percentage of those with impaired DLCO by 20%. Conclusions: One-third of patients with mild COVID-19 have impaired DLCO thirty-four days post-diagnosis. One-fifth of patients have a restrictive spirometric pattern. The criteria that define impaired DLCO and the severity of COVID-19 disease affects the proportion of those with impaired DLCO at follow-up.

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Reference Values for the Diffusing Capacity Determined by the Single-Breath Technique at Different Altitudes: The Latin American Single-Breath Diffusing Capacity Reference Project

Abstract: BACKGROUND: The lung diffusion capacity (D LCO)

Cited by 25 publications

References 20 publications

Valores de referência para a difusão do monóxido de carbono (fator de transferência) em uma amostra brasileira da raça branca

Valores de referência para a difusão do monóxido de carbono (fator de transferência) em uma amostra brasileira da raça branca

Comparing a new device to measure lung volumes with three traditional methods in individuals with different lung conditions

Clinical Predictors of Lung Function in Patients Recovering from Mild COVID-19

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