“…1–5,8,9 These approaches prioritize testing using measures of varying sensitivity and specificity for the diagnosis of CJD, including magnetic resonance (MR) imaging, 10 electroencephalogram (EEG), 11 and cerebrospinal fluid (CSF) biomarkers (i.e., total-tau, 14-3-3 and real-time quaking-induced conversion [RT-QuIC] 12–14 ). The prevalence of specific causes of RPD in a given practice environment are expected to vary with center- (e.g., level of care provided, academic affiliation, referral base 3,7 ), practitioner- (e.g., sub-specialization, clinic wait times 15 ), and patient-specific factors (e.g., age, risk factors and exposures 16,17 ). Accordingly, it remains unclear whether existing approaches are applicable to the diagnosis of RPD in patients assessed in lower-acuity outpatient settings, where the majority of neurological care is delivered.…”