Connections are considered to be one of the most prominent components of steel moment frames and have received studious attention in recent years. The core problem of welded connections is premature brittle fracture of weld in the critical beam-to-column connection region. Within the framework of this issue, various approaches have been proposed to solve the mentioned problem. Intentional weakening of the beam web or flange is in line with the purpose of leading the plastic hinge away from the column face, hence, increasing the ductility. The aim of this research is to investigate the behavior of interior connections subjected to monotonic lateral loading in case of presence of openings in beam web or flange. To do so, an ordinary fully welded rigid connection, reduced beam section, reduced web section, and drilled flange connection models are simulated numerically, utilizing finite element software, ANSYS. The results indicate that scrupulous selection of opening sizes are of great importance to fulfill the desired outcome which is avoiding the brittle failure of connections. Furthermore, the use of drilled flange, reduced beam section, or reduced web section connections satisfy the expected performance and it is proposed to use them according to practicability, architectural and economic considerations as well as site conditions. Shear deformation and local buckling is observed in reduced web section connections while in drilled flange connections, stress concentration around the opening is critical.