2009
DOI: 10.1186/1471-213x-9-3
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Regeneration of the radial nerve cord in the sea cucumber Holothuria glaberrima

Abstract: BackgroundRegeneration of neurons and fibers in the mammalian spinal cord has not been plausible, even though extensive studies have been made to understand the restrictive factors involved. New experimental models and strategies are necessary to determine how new nerve cells are generated and how fibers regrow and connect with their targets in adult animals. Non-vertebrate deuterostomes might provide some answers to these questions. Echinoderms, with their amazing regenerative capacities could serve as model … Show more

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Cited by 40 publications
(34 citation statements)
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“…They are thus considered as excellent models for organ regeneration studies [1], [5], [6], [7]. Regeneration has been the topic of considerable research, with an emphasis on visceral (intestine) regeneration, including the histological changes (for example, tissue layer changes in the intestine wall and changes in the radial nerve cord) and cellular events (cell origin, migration and proliferation) associated with such regeneration [8], [9], [10], [11], [12], [13], [14]. Nevertheless, due to the lack of information on the genome of sea cucumbers, only relatively few genes – such as Ependymin, Wnt9, Bmp1 and Serum amyloid A etc.…”
Section: Introductionmentioning
confidence: 99%
“…They are thus considered as excellent models for organ regeneration studies [1], [5], [6], [7]. Regeneration has been the topic of considerable research, with an emphasis on visceral (intestine) regeneration, including the histological changes (for example, tissue layer changes in the intestine wall and changes in the radial nerve cord) and cellular events (cell origin, migration and proliferation) associated with such regeneration [8], [9], [10], [11], [12], [13], [14]. Nevertheless, due to the lack of information on the genome of sea cucumbers, only relatively few genes – such as Ependymin, Wnt9, Bmp1 and Serum amyloid A etc.…”
Section: Introductionmentioning
confidence: 99%
“…This lack of markers has been an ongoing limitation in our research on nervous system regeneration where we use an echinoderm model system, the sea cucumber Holothuria glaberrima (San Miguel-Ruiz et al 2009, Mashanov et al 2013, Tossas et al 2014). To tackle this problem, the search and characterization of new markers capable of identifying neurons and plexi that form the echinoderm nervous system components are needed.…”
Section: Introductionmentioning
confidence: 99%
“…Our previous research [25,26] has demonstrated that the radial nerve cord of adult sea cucumbers is capable of fast and efficient regrowth and re-connection after complete transection. Detailed microscopic analysis resulted in creation of an atlas of histology and ultrastructure of the normal and regenerating sea cucumber CNS and showed that the response to injury involved activation, dedifferentiation, and increased proliferation of glial cells [25].…”
Section: Introductionmentioning
confidence: 99%