Regenerative Frontiers in Craniofacial Reconstruction: Grand Challenges and Opportunities for the Mammalian Transforming Growth Factor-β Proteins

Ripamonti, Ugo; Klar, Roland M.

doi:10.3389/fphys.2010.00143

Cited by 8 publications

(5 citation statements)

References 52 publications

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“…Calcium (Ca) plays an important role in osteoconductivity and may enhance bone tissue integration by entrapping and concentrating circulating bone growth factors (BMPs) and osteoprogenitor cells, thus imparting osteoinductive properties to calcium-based bone graft materials [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics of Bone Substitutes Used in Oral Surgery in Comparison to Autogenous Bone

Berbéri

Samarani

Nader

et al. 2014

BioMed Research International

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Bone substitutes used in oral surgery include allografts, xenografts, and synthetic materials that are frequently used to compensate bone loss or to reinforce repaired bone, but little is currently known about their physicochemical characteristics. The aim of this study was to evaluate a number of physical and chemical properties in a variety of granulated mineral-based biomaterials used in dentistry and to compare them with those of autogenous bone. Autogenous bone and eight commercial biomaterials of human, bovine, and synthetic origins were studied by high-resolution X-ray diffraction, atomic absorption spectrometry, and laser diffraction to determine their chemical composition, calcium release concentration, crystallinity, and granulation size. The highest calcium release concentration was 24. 94 mg/g for Puros and the lowest one was 2.83 mg/g for Ingenios β-TCP compared to 20.15 mg/g for natural bone. The range of particles sizes, in terms of median size D50, varied between 1.32 μm for BioOss and 902.41 μm for OsteoSponge, compared to 282.1 μm for natural bone. All samples displayed a similar hexagonal shape as bone, except Ingenios β-TCP, Macrobone, and OsteoSponge, which showed rhomboid and triclinic shapes, respectively. Commercial bone substitutes significantly differ in terms of calcium concentration, particle size, and crystallinity, which may affect their in vivo performance.

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Section: Introductionmentioning

confidence: 99%

Physicochemical Characteristics of Bone Substitutes Used in Oral Surgery in Comparison to Autogenous Bone

Berbéri

Samarani

Nader

et al. 2014

BioMed Research International

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“…Ca is important for enhancing the osteoconductive properties and tissue integration of biomaterials (33). Studies have reported that higher calcium concentrations are more prone to resorption and help to compensate for the negative charges of phosphate (34).…”

Section: Discussionmentioning

confidence: 99%

The chemical evaluation of different dental graft materials by energy dispersive X-ray spectrometry technique

Güler¹,

Uraz²,

Çetiner³

2021

Int Dent Res

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Aim: The physicochemical properties of dental graft materials are very important because they strongly influence the bone regeneration capabilities of biomaterials. The purpose of this study is to investigate the chemical composition and surface energies of white (WPTG) and black porous titanium granules (PTG), bovine bone graft and equine-derived bone graft through energy dispersive X-ray spectrometry (EDX) analysis of the comparison. Methodology: The surface chemical compositions of PTG, WPTG, bovine bone graft and equine-derived bone graft were measured by EDX analysis. All graft materials’ morphologic characteristics such as particle and granule dimension were evaluated with Scanning Electron Microscopy (SEM). The EDX measurement of samples was evaluated at between x85 to x50000 magnification. Results: PTG grafts showed elements of sodium (%8.88±9.98), chlor (2.44±1.96) and aluminum (0.99±0.37) as well as titanium (90.06±11.34) molecule at x5000 magnification. In WPTG, titanium (%34.55±6.41) and oxygen (%65.44±6.42) molecules were detected. EDX analyses have detected the presence of sodium, calcium, and phosphorus in the equine-derived and bovine bone graft. Conclusion: It has been found that PTG surface was not made of pure titanium, it has different chemical molecules at larger magnifications and xenografts exhibited different organic material content. Cell culture and experimental studies are needed to establish a relationship between the different commercial dental grafts and their regenerative properties. How to cite this article: Berceste G, Uraz A, Çetiner D. The chemical evaluation of different dental graft materials by energy dispersive X-ray spectrometry technique. Int Dent Res 2021;11(1):23-9. https://doi.org/10.5577/intdentres.2021.vol11.no1.5 Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

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“…TGF‐β3) for periodontal regeneration. The readers are directed to recent review articles for further information (reviewed in ).…”

Section: Other Growth Factors In Periodontal Regenerationmentioning

confidence: 99%

Biological agents and cell therapies in periodontal regeneration

Larjava¹,

Yang²,

Putnins³

et al. 2012

Endodontic Topics

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Regeneration of periodontal structures is a complex challenge for periodontal wound healing. As by Wikesjö et al. in this issue, wound space provision, primary stability, and healing by primary intention serve as critical factors for attempts to regenerate the periodontium. Barrier membranes for space maintenance can be cumbersome to use in a clinical setting and have proven to provide only partial success in regenerative therapies. Not surprisingly, investigators and clinicians have started to search for biological molecules and cell technologies that could help to either speed up or modify the healing process that depends on migration and differentiation of several different cell populations. In this chapter, we will briefly review the technologies that are currently in use or in clinical trials. Readers are welcome to review in‐depth publications for further details on this complex and evolving area of research.

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Regenerative Frontiers in Craniofacial Reconstruction: Grand Challenges and Opportunities for the Mammalian Transforming Growth Factor-β Proteins

Cited by 8 publications

References 52 publications

Physicochemical Characteristics of Bone Substitutes Used in Oral Surgery in Comparison to Autogenous Bone

Physicochemical Characteristics of Bone Substitutes Used in Oral Surgery in Comparison to Autogenous Bone

The chemical evaluation of different dental graft materials by energy dispersive X-ray spectrometry technique

Biological agents and cell therapies in periodontal regeneration

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