Regenerative Medicine: Charting a New Course in Wound Healing

Gurtner, Geoffrey C.; Chapman, Mary Ann

doi:10.1089/wound.2015.0663

Cited by 62 publications

(64 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Wound infection (WI) is an annoying complication for doctors and patients . It does not only prolong in‐hospital time, but also increases therapeutical costs and repetitive admissions to outpatient clinics . Therefore, effective prophylaxis and treatment of WI is critical to assure medical quality.…”

Section: Introductionmentioning

confidence: 99%

The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis

Wang

Long

et al. 2019

Int J Clin Pract

View full text Add to dashboard Cite

Summary Objectives The purpose of this study was to conduct a systematic review and meta‐analysis in patients with local wound infection or infective risk, evaluating effects of topical gentamycin application on prophylaxis and treatment of wound infection. Methods Embase, the Cochrane Library, Pubmed, Medline (from Ovid) and three Chinese literature databases (CNKI, VIP and WANFANG) were searched. Randomised controlled studies (RCTs) and observational studies (OSs) that assessed the efficacy of topical gentamycin application on prophylaxis and treatment of local wound infection were included. The primary outcome was clinical efficacy. Secondary outcomes included duration of recovery time and length of hospital stay. Results Fifteen studies (1781 patients) met inclusion criteria. Twelve studies were RCTs and other three studies were OSs. Compared with non‐gentamycin group, topical gentamycin application had significantly higher rates of clinical efficacy (OR = 3.57, 95% CI 2.52‐5.07). In terms of duration of wound healing, it's taken shorter time in gentamycin group than non‐gentamycin group (OR = −4.94, 95% CI −8.37 to −1.51). However, the length of hospital stay had no significantly difference between the two groups (OR = −3.40, 95% CI −8.42 to 1.63). Subgroup analyses were conducted according to study design (RCTs or OSs), purpose and administration type. And the results showed that there were no significant difference of clinical efficacy in study design (P = 0.21, I2 = 35.4%), purpose (P = 0.32, I2 = 0%) and administration type subgroup (P = 0.74, I2 = 0%). However, topical gentamycin application had significantly shorter duration of wound healing in randomly controlled trials compared with observational studies, but had no difference in terms of administration type(P = 0.20, I2 = 38.6%). Conclusions Studies to date show that topical gentamycin application significantly increases the rate of clinical efficacy and decreases the duration of wound healing in patients with local wound infection or infective risk.

show abstract

Section: Introductionmentioning

confidence: 99%

The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis

Wang

Long

et al. 2019

Int J Clin Pract

View full text Add to dashboard Cite

show abstract

“…Several reviews have been previously published on the topic of regenerative medicine as relevant to wound healing. However, these reviews have so far either primarily addressed each of these regenerative medicine approaches in isolation or focused on chronic wounds . In this review, we discuss the pathophysiology of wounds and present an overview of the latest studies in regenerative medicine and how they maybe applied to stimulate and promote healing in the management of both acute and chronic wounds.…”

Section: Introductionmentioning

confidence: 99%

An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing

Pang

Ibrahim

Bulstrode

et al. 2017

International Wound Journal

View full text Add to dashboard Cite

The global burden of disease associated with wounds is an increasingly significant public health concern. Current treatments are often expensive, time‐consuming and limited in their efficacy in chronic wounds. The challenge of overcoming current barriers associated with wound care requires innovative management techniques. Regenerative medicine is an emerging field of research that focuses on the repair, replacement or regeneration of cells, tissues or organs to restore impaired function. This article provides an overview of the pathophysiology of wound healing and reviews the latest evidence on the application of the principal components of regenerative medicine (growth factors, stem cell transplantation, biomaterials and tissue engineering) as therapeutic targets. Improved knowledge and understanding of the pathophysiology of wound healing has pointed to new therapeutic targets. Regenerative medicine has the potential to underpin the design of specific target therapies in acute and chronic wound healing. This personalised approach could eventually reduce the burden of disease associated with wound healing. Further evidence is required in the form of large animal studies and clinical trials to assess long‐term efficacy and safety of these new treatments.

show abstract

“…TE (Tissue Engineering) aims to apply the principles of engineering and life sciences toward the manufacturing of bio-substitutes to restore, maintain, enhance or replace failing human tissues or organs [1][2][3]. Since the first report of this research field over 30 years ago [4], dramatic advances and developments have been made.…”

Section: Introductionmentioning

confidence: 99%

“…This is mainly due to several translational challenges. First of all, the mechanistic understanding of the relationships among molecules, cells, tissues and organs as a whole during tissue regeneration is somewhat limited [3,7], even though the recognition and incorporation of these relationships and the underpinning biological processes is an inherent characteristic of TE [3,6]. Secondly, there is no gold standard or generic procedure for tissue culture as a great amount of research efforts have been pursued to develop diverse 3D (three-dimensional) scaffolds, media and tissue culturing protocols [5,7].…”

Section: Introductionmentioning

confidence: 99%

Mechanistic Insights of Cells in Porous Scaffolds via Integrated Culture Technologies

Gabbott¹,

Sun²

2017

JLS

View full text Add to dashboard Cite

This research aimed to combine 3 cell and tissue culture technologies to obtain mechanistic insights of cells in porous scaffolds. When cultivated on 2D (2-dimensional) surfaces, HDFs (human dermal fibroblasts) behaved individually and had no strict requirement on seeding density for proliferation; while HaCat cells relied heavily on initial densities for proliferation and colony formation, which was facilitated when co-cultured with HDFs. Experiments using a 3D CCIS (3-dimensional cell culture and imaging system) indicated that HDFs colonised open pores of varying sizes (125-420 μm) on modular substrates via bridge structures; while HaCat cells formed aperture structures and only colonised small pores (125 μm). When co-cultured, HDFs not only facilitated HaCat attachment on the substrates, but also coordinated with HaCat cells to colonise open pores of varying sizes via bridge and aperture structures. Based on these observations, a 2-stage strategy for the culture of HDFs and HaCat cells on porous scaffolds was proposed and applied successfully on a cellulosic scaffold. This research demonstrated that cell colonisation in scaffolds was dependent on multiple factors; while the integrated 2D&3D culture technologies and the 3D CCIS was an effective and efficient approach to obtain mechanistic insights of their influences on tissue regeneration.

show abstract

Regenerative Medicine: Charting a New Course in Wound Healing

Cited by 62 publications

References 99 publications

The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis

The efficacy of topical gentamycin application on prophylaxis and treatment of wound infection: A systematic review and meta‐analysis

An overview of the therapeutic potential of regenerative medicine in cutaneous wound healing

Mechanistic Insights of Cells in Porous Scaffolds via Integrated Culture Technologies

Contact Info

Product

Resources

About