This paper analyzed the evolution of climate data in the Rio Bravo Basin in Mexico from 1980-2009 and projects future climate conditions in this region. Then, the potential impacts of climate change on water resources for crops in the nine irrigation districts (IDs) of the Rio Bravo Basin were evaluated. Specifically, climate data on precipitation, maximum and minimum temperatures, and evapotranspiration from the baseline period of 1980-2009 were compared with projected climate conditions for 2015-2039, 2045-2069, and 2075-2099. The projections were based on two representative concentration pathways (RCPs) of greenhouse gases in the atmosphere (RCP4.5 and RCP8.5). Patterns in the behavior of the analyzed climate variables over the past ten decades were examined and compared to the projected evolution of these variables through to the end of the century. Overall, in the future, temperatures, rates of evapotranspiration, and crop water demand are expected to increase. Also, the future precipitation patterns of all IDs were modified under the considered scenarios. Finally, the IDs of Acuña-Falcón and Delicias will be the most impacted by climate changes, while Palestina will be the least affected.