Regional Changes in Myocardial Strain Predict Ventricular Remodelling after Myocardial Infarction in a Large Animal Model

Abstract

To identify early predictors of late left ventricular remodelling (LVR) post-myocardial infarction (MI) and related molecular signatures, a porcine model of closed-chest balloon MI was used. LVR was assessed by cardiac magnetic resonance imaging (CMRI) at baseline, 12–48 hours (acute), and 5–6 weeks (chronic) post-MI. Changes in myocardial strain and strain rates were derived from CMRI data. Tissue proteomics was compared between infarcted and non-infarcted territories. Peak values of left ventricular (LV) apical circumferential strain (ACS) changed over time together with peak global circumferential strain (GCS) while peak GLS epicardial strains or strain rates did not change over time. LVR post-MI enhanced abundance of 39 proteins in infarcted LV territories,21 of which correlated with LV equatorial circumferential strain rate (ECSR). The strongest associations were observed for D-3-phosphoglycerate dehydrogenase (D-3PGDH), cysteine and glycine-rich protein-2 (CG-RP-2), and secreted frizzled-related protein 1 (sFRP1). Results indicate that early changes in regional peak ACS predict late LV remodelling and LVR post-MI is associated with augmented levels of D-3PGDH and sFRP1, which show the strongest association with peak ECSR. These findings might help to prevent LVR post-MI by influencing/directing LV unloading strategies or by pharmacological control of tissue levels of D-3PGDH and sFRP1.

From multi-omics approaches to personalized medicine in myocardial infarction

“…LVR is a prevalent complication following MI, and researchers have identified several potential protein biomarkers associated with this condition. These biomarkers include apolipoprotein A1, immunoglobulin A, interleukin-17E, tissue inhibitor of metalloproteinases-1, urokinase-type plasminogen activator, midkine, proprotein convertase subtilisin/kexin type 6, among others (170,173,174). Furthermore, proteomic studies can provide useful information in assessing left ventricular ejection fraction (LVEF) and infarct size after MI (175).…”