Regional flow motion and heat energy balance analysis of a 10,000 class pharmaceutical cleanroom with secondary return air conditioning system

Zhao, Fu-Yun; Cheng, Jin; Liang, Bao; Huang, Zhi Cheng; Zhang, Yijing; Li, Xianting

doi:10.1016/j.ijrefrig.2021.03.021

Cited by 7 publications

(5 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The suitability of using CFD for airflow simulation and contaminants in a cleanroom is confirmed by several studies [19,32,47]. The SIMPLE algorithm was used in the study and the convergence criteria were set as 10 −4 , with the exception of energy which was set as 10 −6 [31].…”

Section: Discussionmentioning

confidence: 90%

“…A computational fluid dynamics (CFD) model was created using ANSYS software (Fluent) to calculate air distribution and particle flow in the cleanroom. The same procedure for calculating the air distribution was used in the study released by Zao et al [32]. The suitability of using CFD simulation is also reported by Villafruela et al [37], which monitors the influence of the location, the types of distribution elements, and the source of pollution.…”

Section: Methodsmentioning

confidence: 85%

“…The increase of ACH from 15 h −1 to 20 h −1 did not significantly affect the pollutant removal efficiency in the occupied zone of a Class 10,000 cleanroom model. On the other hand, increasing the ACH from 20 h −1 to 25 h −1 showed a visible reduction in room residence time from 32% to 21% [32]. In contrast to the study by Zao et al the study focused on the higher ACH range, 20-40 h −1 , typical of purity classes ISO EN 7-8, where most operating theaters are included.…”

Section: Introductionmentioning

confidence: 81%

“…Moving a human body into the path of internal ventilation flows can also cause the penetration of particles [60]. Higher ACHs, which are often accompanied by a higher airflow rate via the distribution elements, create a feeling of thermal discomfort [32]. Thermal discomfort could cause doctors to commit errors in a clean room, which could, in turn, lead to health hazards.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Impact of the Speed of Airflow in a Cleanroom on the Degree of Air Pollution

et al. 2022

View full text Add to dashboard Cite

The high-energy requirements of cleanrooms are the main motivation for optimizing their operational conditions. The ventilation system consumes the most energy in order to ensure the precise air conditioning of the room (filtration, temperature, and humidity adjustment). The main function of the ventilation system is to keep particle concentration to a minimum. This work deals with the optimization of an experimental operating room via the optimization of air supply through the distribution element (laminar airflow ceiling) in the range of 0.15–0.25 m·s−1. The laminar airflow between the distribution element and the patient is influenced by the operating light and different airflow velocities. These factors affect changes in particle concentration. Ansys Fluent software was used to investigate the nature of the flow, velocity profiles, and particle trajectories. The results of our numerical simulation demonstrate that a suitable flow rate setting increases the efficiency of particle reduction in the operating table area by up to 54%, which can, in turn, reduce operating costs. The simulated air velocity profile was subsequently verified using the particle image velocimetry (PIV) method. The typical size of particles monitored for in cleanrooms is 0.5 μm according to ISO EN 7. Therefore, the results of this study should be helpful in correctly designing distribution elements for clean rooms.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Methodsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of the Speed of Airflow in a Cleanroom on the Degree of Air Pollution

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Zhao et al [27] investigated the effect of increasing the ACH and returning the air volume in contaminant concentration in occupied zone and unoccupied zone in a Class 10,000 cleanroom. Prager et al [28] evaluated the influence of bin stacking arrangements and fan position on the airflow in an industrial apple storage room. They found that locating the fan above the gaps was more efficient for bin ventilation than directly above the bins.…”

Section: Introductionmentioning

confidence: 99%