Regional gastrointestinal contractility parameters using the wireless motility capsule: inter‐observer reproducibility and influence of age, gender and study country

Farmer, Adam D.; Wegeberg, Anne-Marie; Brock, Birgitte; Hobson, Anthony; Mohammed, Sahar; Scott, S. M.; Bruckner-Holt, Caroline; Semler, John R.; Hasler, William L.; Hellström, Per M.; Drewes, Asbjørn Mohr; Brock, Christina

doi:10.1111/apt.14438

Cited by 40 publications

(52 citation statements)

References 39 publications

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“…However, electrogastrography provides no information on GE and there has never been widely uptake of the method. (c) The wireless motility capsule, which records pressure, pH, and temperature during its passage through the gastrointestinal tract . The method is well‐validated, and it is easy to use and robust normative data for overall and regional transit times as well as measure of contractile activity are available .…”

Section: Discussionsupporting

confidence: 83%

“…In the present study, median GE time of the 3D‐Transit capsule was 2.7 hours. This is very close to results from the wireless motility capsule (where median gastric emptying was 3.2, 3.23 and 3.25 hours even though the size of the wireless motility capsule is significantly larger than the 3D‐Transit capsule (3D‐Transit capsule 8.3 × 21.5 mm; wireless motility capsule 11.7 × 26.8 mm) …”

Section: Discussionmentioning

confidence: 99%

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Normative values for gastric motility assessed with the 3D‐transit electromagnetic tracking system

Sutter

Klinge

Mark

et al. 2020

Neurogastroenterology Motil

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Background:The Motilis 3D-Transit system allows ambulatory description of transit patterns throughout the gastrointestinal tract and offers an alternative method for studying gastric motility. We aimed to establish normative values for gastric motility assessed with the method. Method:A total of 132 healthy volunteers ingested the 3D-Transit capsule for assessment of gastrointestinal transit times. Recordings from 125 subjects were used for definition of normative values. Forty-six subjects were studied on two consecutive days. Recordings were reanalyzed using newly developed software providing information on gastric emptying (GE) as well as contraction frequency and movement during gastric contractions. Results:The median GE time was 2.7 hours (range 0.1-21.2). In 89% of subjects, the capsule passed the pylorus within a postingestion period of 6 hours. The median frequency of gastric contractions was 3.1 per minute (range 2.6-3.8). The frequency was higher in women (3.2, range 2.7-3.8) than in men (3.0, range 2.6-3.5) and increased with age (0.004 per year) (P < .05). The median amplitudes were 35° (range 4-85) when based on rotation of the capsule and 11 mm (range 6-31) when based on capsule change in position. The rotation amplitude was higher in women and decreased with increasing BMI (P < .05). The position amplitude was also higher in women and increased with the amount of calories in the test meal, but decreased with increasing BMI and age (P < .05). Day-to-day variation (P > .05) was considerable while interrater variability was small. Conclusion and Inferences:We have established normative values for gastric motility assessed with the 3D-Transit system. K E Y W O R D S gastric motility, gastroenterology, gastrointestinal motility, neurogastroenterology S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Sutter N, Klinge MW, Mark EB, et al.Normative values for gastric motility assessed with the 3D-transit electromagnetic tracking system. Neurogastroenterol

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Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Normative values for gastric motility assessed with the 3D‐transit electromagnetic tracking system

Sutter

Klinge

Mark

et al. 2020

Neurogastroenterology Motil

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“…Contractility Measures — The WMC data allows the measurement of a regional log motility index, which is a composite measure first proposed by Camilleri et al The log motility index is derived from the natural log of the (sum of amplitudes × number of contractions +1). The regional log motility index has previously been demonstrated to be a useful summary measure of the respective total contractions, sum of amplitudes, area under the contraction curve and contraction frequency within a segment …”

Section: Methodsmentioning

confidence: 99%

“…The regional log motility index has previously been demonstrated to be a useful summary measure of the respective total contractions, sum of amplitudes, area under the contraction curve and contraction frequency within a segment. 25 with descriptors for intensity and unpleasantness placed along the scale to aid in rating. The scales have been validated as providing interval level measurement of magnitude and have been used both to assess acute and chronic visceral symptoms.…”

Section: Key Pointsmentioning

confidence: 99%

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Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation

Farmer

Ruffle

Hobson

2018

Neurogastroenterology Motil

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Background Linaclotide is efficacious in the management of irritable bowel syndrome with constipation (IBS‐C), yet relatively little is known regarding its effect on human gastrointestinal physiology. The primary aim of the study was to examine the effect of linaclotide on change in pH across the ileocecal junction (ICJ), a proposed measure of cecal fermentation, and its relationship to symptoms and quality of life (QoL) in IBS‐C. Methods A total of 13 participants with Rome III IBS‐C underwent a standardized wireless motility capsule (WMC). Stool consistency was measured using the Bristol stool form scale (BSFS) and frequency with spontaneous bowel movements (SBM). Gastrointestinal symptoms and QoL were assessed using validated questionnaires. The WMC and questionnaires were repeated after 28 days of linaclotide 290 g po od. Key Results Linaclotide reduced the change in pH across the ICJ (−2.4 ± 0.2 vs −2.1 ± 0.4, P = 0.01) as a function of a relative alkalinization of the cecum (5.2 ± 0.2 vs 5.5 ± 0.3, P = 0.02). Linaclotide accelerated colonic transit time (2650 minutes (2171‐4038) vs. 1757 (112‐3011), P = 0.02), increased colonic log motility index (15 ± 1.8 vs. 16.5 ± 1.8, P = 0.004) but had no effect of gastric emptying or small bowel transit. Change in pH across the ICJ correlated with improvement in symptom intensity, unpleasantness, and visceral sensitivity index (r = 0.62, P = 0.03, r = 0.63, P = 0.02, r = 0.62, P = 0.02) and with increases in BSFS type and SBM (r = 0.9, P < 0.0001, r = 0.6, P = 0.02). Conclusions & Inferences Linaclotide's effects are confined to the colon where it increases cecal pH, potentially representing a reduction in cecal fermentation and accelerates colonic motility.

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Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls

et al. 2021

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Background Diabetic constipation is traditionally attributed to slow colonic transit, despite limited evidence. More than half of patients find treatment unsatisfactory. To improve treatment, there is a need for better diagnostic understanding of the condition. Objective In this wireless motility capsule study, we aimed to investigate gastrointestinal transit and contractility in diabetes patients with and without constipation, and in healthy controls. Methods We prospectively included type 1 or type 2 diabetes patients with gastrointestinal symptoms. Based on the Gastrointestinal Symptom Rating Scale we distinguished into two groups: with constipation and without constipation. Non‐diabetic controls were asymptomatic. All were examined with wireless motility capsule, determining transit times and contractility parameters. Results 57 patients (42 women, 46 with type 1 diabetes) and 26 healthy controls (14 women) were included. We found no difference in transit times between diabetes patients with and without constipation. Compared to healthy controls (35:55, h:min), whole‐gut transit was slower in both diabetes patients with constipation (66:15, p = 0.03) and without constipation (71:16, p < 0.001). Small bowel motility index correlated rs = −0.32 (p = 0.01) with constipation symptoms. Conclusions Diabetes patients with constipation had similar transit times as those without constipation. Both groups had slower whole‐gut transit than healthy controls. Constipation was associated with reduced small bowel, but not colonic contractility. Our results imply that other mechanisms than slow colonic transit may be more important in the pathogenesis of diabetic constipation.

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Regional gastrointestinal contractility parameters using the wireless motility capsule: inter‐observer reproducibility and influence of age, gender and study country

Cited by 40 publications

References 39 publications

Normative values for gastric motility assessed with the 3D‐transit electromagnetic tracking system

Normative values for gastric motility assessed with the 3D‐transit electromagnetic tracking system

Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation

Gastrointestinal transit and contractility in diabetic constipation: A wireless motility capsule study on diabetes patients and healthy controls

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