Regioselective and asymmetric allylic alkylation of vinyl epoxides for the construction of allylic alcohols via synergistic catalysis

Asymmetric dearomatization of benzyl 1-naphthyl ethers via [1,3] O-to-C rearrangement

“…Based on the above analysis and our previous work, 8,11 a possible catalytic cycle with a transition state model was proposed. As shown in Scheme 4, the benzyl 1-naphthyl ethers use two oxygen atoms to coordinate with the chiral N , N ′-dioxide-cobalt( ii ) complex ( INT1 ), which weakens the C–O bond and facilitates its cleavage to provide a tight ion-pair intermediate TS1 containing the benzyl cation and an enolate anion counterpart.…”

Concise synthesis of chiral γ-butenolides via an allylation/lactonization cascade reaction

“…As part of continuous efforts in asymmetric allylation reactions by N , N ′-dioxide/metal complexes 8,9 and motivated by our previous research on the construction of α-methylene-γ-butyrolactones via the asymmetric allylboration/lactonization reaction, 10 we envisaged that the stereoselective allylation of enone diesters 11 could produce α,β-unsaturated-γ-hydroxy ester intermediates, which may undergo subsequent lactonization to afford the corresponding chiral butenolides (Scheme 1c). Herein, we wish to report our endeavor along this line.…”