Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats

Boor, Peter; Celec, Peter; Behuliak, Michal; Grančič, Peter; Kebis, Anton; Kukan, M; Pronayová, Nadežda; Liptaj, Tibor; Ostendorf, Tammo; Šebeková, Katarı́na

doi:10.1016/j.metabol.2009.05.025

Cited by 108 publications

(101 citation statements)

References 38 publications

(69 reference statements)

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“…However, the difference in intensity of exercise may not be responsible for the difference in the effect on insulin levels. Our results are in agreement with other authors who, using intensities ranging 20-26 m/min for Ͼ5 wk, have reported no reductions in insulin levels with exercise (11,18,19,33).…”

Section: Discussionsupporting

confidence: 94%

“…Xiang et al (74) have reported a decrease in insulin levels with exercise. However, a number of other studies have reported no reductions in plasma insulin levels with exercise in obese rats (11,14,19,33,35,63) as well as humans (64). Although some studies have reported that insulin resistance in this model is refractory to exercise (41), others have reported improvements (36,71).…”

Section: Discussionmentioning

confidence: 95%

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Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D₁receptor dysfunction in obese rats

Muhammad

Lokhandwala

Banday

2011

American Journal of Physiology-Renal Physiology

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 95%

Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D₁receptor dysfunction in obese rats

Muhammad

Lokhandwala

Banday

2011

American Journal of Physiology-Renal Physiology

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“…Accordingly, BUN and Cr were also decreased by exercise. It has been reported before that exercise can improve kidney function by improving metabolic factors and glomerular filtration rate and reduction of albuminuria (33)(34)(35). It seems that exercise during CP therapy could reduce the CP-induced oxidative stress and prevent renal dysfunction.…”

Section: Discussionmentioning

confidence: 96%

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

et al. 2015

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Background: Cisplatin (CP) is a chemotherapy drug and nephrotoxicity is considered as its major side effect. Aerobic exercise is well known as an approach to reduce the side effects of many drugs. Objectives: This study was designed to determine the protective role of aerobic exercise against CP-induced nephrotoxicity. Materials and Methods: Thirty male Wistar rats were randomly divided into four groups. Group I had aerobic exercise on a treadmill one hour per day and five days per week for eight weeks. Then, the exercise protocol was continued for another week, but during this week, the animals also received CP (2.5 mg/kg/day; ip). Group II underwent the same protocol as group I without exercise in the last week during the CP therapy. Groups III and IV were assigned as positive and negative control groups, and were treated with CP and saline without exercise, respectively. Finally, the animals were sacrificed for the biochemical measurement and tissue histopathology investigation. Results: CP alone without exercise increased serum levels of blood urea nitrogen (BUN), creatinine (Cr), and malondialdehyde (MDA); and kidney nitrite level, while treadmill exercise in group I significantly ameliorated these parameters (P < 0.05). Kidney and serum levels of MDA and nitrite did not alter significantly. Also, the severity of kidney tissue damage decreased significantly in groups I and II (P < 0.05). Conclusions: Aerobic exercise may reduce CP-induced nephrotoxicity with a favorable effect on renal function by increasing activation of antioxidant system.

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“…The exercise protocols were performed 5 days per week for 4 weeks. These exercise programs are considered to be of moderate intensity [28].…”

Section: Exercise Training Protocolmentioning

confidence: 99%

Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models

et al. 2014

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BACKGROUND/OBJECTIVES:Irisin, a newly identified hormone, is associated with energy homeostasis. We investigated whether aged garlic extract (AGE) and exercise training intervention could improve body weight, insulin sensitivity, skeletal muscle fibronectin domain containing protein 5 (FNDC-5) levels, and plasma irisin in high-fat diet (HFD). MATERIALS/METHODS: Male Sprague Dawley rats were fed a ND (normal diet, n = 5) or HFD (n = 28) for 6 weeks. After 6 weeks, all rats were divided into 5 groups for the next 4 weeks: ND, (normal diet, n = 5), HFD (high-fat diet, n = 7), HFDA (high-fat diet + aged garlic extract, n = 7), HFDE (high-fat diet + exercise, n = 7), and HFDEA (high-fat diet + exercise + aged garlic extract, n = 7). Exercise groups performed treadmill exercises for 15-60 min, 5 days/week, and AGE groups received AGE (2.86 g/kg, orally injected) for 4 weeks. RESULTS: Significant decreases in body weight were observed in the ND, HFDE, and HFDEA groups, as compared with the HFD group. Neither intervention affected the masses of the gastrocnemius muscle or liver. There were no significant differences in glucose levels across the groups. The homeostatic model assessments of insulin resistance were significantly higher in the HFD group, as compared with the ND, HFDA, HFDE, and HFDEA groups. However, skeletal muscle FNDC-5 levels and plasma irisin concentrations were unaffected by AGE or exercise in obese rats. AGE supplementation and exercise training did not affect skeletal muscle FNDC-5 or plasma irisin, which are associated with insulin sensitivity in obese rats. CONCLUSION: Our results suggest that the protection against HFD-induced increases in body fat/weight and insulin resistance that are provided by AGE supplementation and exercise training may not be mediated by the regulation of FNDC-5 or irisin.

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Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats

Cited by 108 publications

References 38 publications

Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D₁receptor dysfunction in obese rats

Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D₁receptor dysfunction in obese rats

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models

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Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats

Cited by 108 publications

References 38 publications

Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1receptor dysfunction in obese rats

Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D1receptor dysfunction in obese rats

Protective Role of Aerobic Exercise Against Cisplatin-Induced Nephrotoxicity in Rats

Effects of aged garlic extract and endurance exercise on skeletal muscle FNDC-5 and circulating irisin in high-fat-diet rat models

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Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D₁receptor dysfunction in obese rats

Exercise reduces oxidative stress but does not alleviate hyperinsulinemia or renal dopamine D₁receptor dysfunction in obese rats