Regulation of Ca2+ uptake in skeletal muscle by 1,25-dihydroxyvitamin D3: Role of phosphorylation and calmodulin

Massheimer, Virginia; Fernández, Luis M.; Boland, Ricardo; Boland, Ana Russo de

doi:10.1016/0303-7207(92)90066-f

Cited by 26 publications

(9 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In animals, circulating 25(OH)D levels <20 ng/mL result in smaller diaphragm muscle fiber diameter and a reduced ability to generate inspiratory force, as compared to animals with levels ≥20 ng/mL 25 . Moreover, in vitro studies suggest that vitamin D supplementation induces rapid changes in calcium metabolism of muscle cells 26 . When 1,25‐dihydroxyvitamin D (1,25(OH) 2 D) (the most biologically active vitamin D metabolite) binds the vitamin D membrane receptor (VDR), it triggers second‐messenger pathways in the muscle cell, 27 which result in enhanced calcium uptake 28 .…”

Section: Discussionmentioning

confidence: 99%

Plasma 25‐Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients

Quraishi

McCarthy

Blum

et al. 2015

J Parenter Enteral Nutr

View full text Add to dashboard Cite

Objective Limited data exist regarding the relationship between plasma 25-hydroxyvitamin D levels and duration of respiratory support. Our goal was to explore whether vitamin D status at the time of intensive care unit (ICU) admission is associated with duration of mechanical ventilation in critically ill surgical patients. Materials and Methods We analyzed data from a prospective cohort study involving 210 critically ill surgical patients. To explore the relationship between admission plasma 25-hydroxyvitamin D levels and duration of mechanical ventilation, we performed a Poisson regression while controlling for clinically relevant covariates. Only patients who required ≥48 hours of mechanical ventilation and survived ≥24 hours after discontinuation of respiratory support were included in the analytic cohort. Results Ninety-four patients met inclusion criteria. Mean (standard deviation) plasma 25-hydroxyvitamin D level was 16 (7) ng/mL and median (interquartile range) duration of mechanical ventilation was 4 (2–7) days. Poisson regression analysis, adjusted for age, sex, race, body mass index, primary surgical service, Acute Physiology and Chronic Health Evaluation II score, and season of ICU admission, demonstrated an inverse association of plasma 25-hydroxyvitamin D levels with duration of mechanical ventilation (incident rate ratio per 10 ng/mL, 0.66; 95% confidence interval, 0.54–0.82). Conclusions In our cohort of critically ill surgical patients, plasma 25-hydroxyvitamin D levels measured on ICU admission were inversely associated with the duration of respiratory support. Randomized controlled trials are needed to assess whether vitamin D supplementation can influence duration of mechanical ventilation in surgical ICU patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma 25‐Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients

Quraishi

McCarthy

Blum

et al. 2015

J Parenter Enteral Nutr

View full text Add to dashboard Cite

show abstract

“…In parallel with the increase in 45Ca uptake, there was an increase of CaM in the microsomal, mitochondrial and myofibrillar fractions and a concomitant decrease in the cytosol (87). In the soleus muscle, calcitriol stimulated binding of CaM to two microsomal proteins of 28 kd and 30 kd within 1 min of exposure to the hormone (137). Increases in CaM mRNA levels in the calcitriol-treated myoblasts paralleled a general calcitriol-mediated stimulation of e Hlthymid ine incorporation into DNA, suggesting it could be involved in the mitogenic action of the hormone.…”

Section: Role Of Cam In Calcitriol-mediated Calcium Uptake In Intestimentioning

confidence: 92%

Calmodulin in Neurotransmitter and Hormone Action

Gnegy¹

1993

Annu. Rev. Pharmacol. Toxicol.

View full text Add to dashboard Cite

Although CaM exists in abundance in many cells, it can be regulated by hormones and neurotransmitters on several levels in a variety of tissues and systems. Neurotransmitter action can lead to a rapid and direct activation of CaM-dependent enzymes or binding of CaM to other CaM-BPs, while persistent stimulation results in a redistribution of CaM and CaM-BPs on a slightly longer time-scale. Long-term neurotransmitter or hormone action or changes in their activity due to drug intervention may lead to changes in cellular CaM content. Both the change in localization of CaM and the long-term increases in CaM content will result in an increase in the sensitivity of Ca(2+)-related processes in select areas. The change in CaM content may be a homeostatic response that would signal an enhanced requirement and sensitivity for a Ca2+/CaM-dependent process or a compensatory reaction titrating chronic changes in Ca2+ within the cell. Both CaM content and localization are highly responsive to changes in [Ca2+]i, but other messengers such as cAMP play a distinct role in both processes. Many changes in CaM, both short and long-term, may involve rearrangements of cytoskeletal proteins, since many CaM-BPs have cytoskeletal localizations and binding of CaM to many of the proteins affects cytoskeletal protein-protein interactions. Therefore, changes in CaM distribution and content, besides altering the activities of the many CaM-dependent enzymes, could also be involved in restructuring in cytoskeletal processes, such as synaptic morphology, vesicular or protein transport, or secretion, that result from an initial neurotransmitter or hormone stimulation.

show abstract

“…La baja ingesta de vitamina D en la población de nuestro estudio puede estar relacionada con el dolor inespecífico que presentan estos pacientes. El aporte de vitamina D induce rápidos cambios en el metabolismo del Ca de la célula muscular, que actúa directamente su membrana, activando varias vías de segundos mensajeros (cAMP, diacilglicerol, inositoltrifostato y ácido araquidónico), lo que potencia la entrada de Ca en escasos minutos (63). Por tanto un bajo consumo de vitamina D, no solo afecta de manera negativa al turnover óseo sino al metabolismo muscular pudiendo empeorar las dolencias de los tres grupos de pacientes.…”

Section: Discussionunclassified

Factores de riesgo relacionados con los hábitos de vida en pacientes con patología osteomuscular

et al. 2017

View full text Add to dashboard Cite

Factores de riesgo relacionados con los hábitos de vida en pacientes con patología osteomuscular Risk factors related with lifestyle in patients with musculoskeletal disorders AbstractBackground: Musculoskeletal disorders (MSDs) encompass a series of debilitating diseases with high incidence and prevalence, representing a high economic and social cost. Prevention is crucial, so is of great interest to determine modifi able risk factors, such as those related to lifestyle. Methods: A descriptive cross-sectional study was performed in 91 patients selected by systematic random sampling and were divided into three experimental groups according to the cause and evolution of its MSD (neck pain, knee pain and back pain). A biometric measurement, nutritional assessment, physical and occupational activity, muscle balance and oxidative status was performed. Results: The female is the most affected gender by the presence of musculoskeletal injuries such as neck pain and back pain. Overall, most patients (67.4%) had normal weight, overweight 24.41% and only 8.1% were obese type I. Patients with neck pain are the group doing less physical activity and worse muscular balance present. Oxidative stress was higher in patients with knee pain than in the other groups. Regarding the consumed diet, differences between experimental groups on the mineral content (Zn, Mn, Se and I) and vitamins (folate and ascorbic acid) are observed. Conclusions: Cholecalciferol intake and vitamins A and D is less than those recommended in all subjects, which promotes muscle disease. Folate intake was below recommendations, increasing susceptibility to oxidative stress. Obesity and oxidative stress related to the prevalence of the different types of MSDs studied.

show abstract

Regulation of Ca2+ uptake in skeletal muscle by 1,25-dihydroxyvitamin D3: Role of phosphorylation and calmodulin

Cited by 26 publications

References 34 publications

Plasma 25‐Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients

Plasma 25‐Hydroxyvitamin D Levels at Initiation of Care and Duration of Mechanical Ventilation in Critically Ill Surgical Patients

Calmodulin in Neurotransmitter and Hormone Action

Factores de riesgo relacionados con los hábitos de vida en pacientes con patología osteomuscular

Contact Info

Product

Resources

About