2003
DOI: 10.1074/jbc.m208049200
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Regulation of Human COL9A1 Gene Expression

Abstract: The COL9A1 gene contains two promoter regions, one driving expression of a long ␣1(IX) chain in cartilage (upstream) and one driving expression of a shorter chain in the cornea and vitreous (downstream). To determine how the chondrocyte-specific expression of the COL9A1 gene is regulated, we have begun to characterize the upstream chondrocyte-specific promoter region of the human COL9A1 gene. Transient-transfection analyses performed in rat chondrosarcoma (RCS) cells, human chondrosarcoma (HTB) cells, and NIH/… Show more

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Cited by 111 publications
(37 citation statements)
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“…This effect of L-SOX5 and SOX6 to SOX9 is not consistent among all cartilage matrix genes, however. For example, SOX9-mediated transcription from the COL9A1 promoter is not stimulated by L-SOX5 and SOX6 (19). In the pellet culture of hMSC and hDFB cells, we observed no additive effect of L-SOX5 and SOX6 to SOX9 activity, whereas SOX9 expression itself was sufficient for CRTL1 induction.…”
Section: Function Of the Sox9-dependent Enhancer Element In A Chondromentioning
confidence: 55%
“…This effect of L-SOX5 and SOX6 to SOX9 is not consistent among all cartilage matrix genes, however. For example, SOX9-mediated transcription from the COL9A1 promoter is not stimulated by L-SOX5 and SOX6 (19). In the pellet culture of hMSC and hDFB cells, we observed no additive effect of L-SOX5 and SOX6 to SOX9 activity, whereas SOX9 expression itself was sufficient for CRTL1 induction.…”
Section: Function Of the Sox9-dependent Enhancer Element In A Chondromentioning
confidence: 55%
“…3D). Some 3 -SOX9 with three different lysine-to-alanine mutations was cotransfected into COS-7 cells with GFP-PIAS1 and FLAG-SUMO-1. Equal amounts of total cell lysates were loaded on the gel, and wild-type or mutant HA 3 -SOX9 was detected with anti-HA monoclonal antibody.…”
Section: Pias1 -X␣ -X␤ and -3 Enhance Sox9-dependent Transactivatimentioning
confidence: 99%
“…Members of the SOX9 family of transcription factors contain a high mobility group (HMG) 3 box DNA-binding domain that is at least 50% identical to an equivalent domain in the sex-determining factor SRY (8). SOX9 also contains a potent transcriptional activation domain located at its C-terminal end.…”
mentioning
confidence: 99%
“…Members of the SOX family have been found to be responsible for the transcriptional regulation of type II and IX collagen genes including COL2A1 and COL9A1 (Bell et al 1997, Stokes et al 2001. Particularly, SOX9 played an important role in COL9A1 gene expression (Zhang et al 2003). Therefore, one can argue that via members of SOX family, TSH may be involved in the regulation of collagen synthesis during cartilage generation.…”
Section: Discussionmentioning
confidence: 99%