1999
DOI: 10.1016/s0014-5793(99)01469-6
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Regulation of IGF‐I, IGFBP‐4 and IGFBP‐5 gene expression by loading in mouse skeletal muscle

Abstract: Gene expression of IGF-I, IGFBP-4 and IGFBP-5 was studied in hindhimb skeletal muscle of mice, which were either overloaded or unloaded for 8 days. Overloading induced a 15% hypertrophy in soleus muscle associated with a 60% increase of IGF-I transcript levels and a doubling of IGFBP-4 mRNA levels. IGFBP-5 mRNA levels were decreased to one third of the control value. Changes in IGFBPs mRNA always preceded changes in IGF-I gene expression. Unloading by hindlimb suspension resulted in atrophy of soleus muscle (2… Show more

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Cited by 85 publications
(92 citation statements)
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“…The widespread growth retardation demonstrated by transgenic mice that overexpress IGFBP-5 suggests that its predominant effect is inhibitory (Salih et al 2004). In arthritic rats, we found an increase in muscular IGFBP-5 gene expression, which has been previously reported in muscular atrophy (Awede et al 1999) and in chondrocytes isolated from osteoarthritic cartilage (Olney et al 1996). The increase in IGFBP-5 in arthritic rats is probably not secondary to the increase in muscular IGF-I, since it has been recently observed in transgenic mice that overexpress IGF-I in muscle that IGFBP-5 mRNA expression was not affected (Musaro et al 2001, Oliver et al 2005.…”
Section: Discussionsupporting
confidence: 81%
“…The widespread growth retardation demonstrated by transgenic mice that overexpress IGFBP-5 suggests that its predominant effect is inhibitory (Salih et al 2004). In arthritic rats, we found an increase in muscular IGFBP-5 gene expression, which has been previously reported in muscular atrophy (Awede et al 1999) and in chondrocytes isolated from osteoarthritic cartilage (Olney et al 1996). The increase in IGFBP-5 in arthritic rats is probably not secondary to the increase in muscular IGF-I, since it has been recently observed in transgenic mice that overexpress IGF-I in muscle that IGFBP-5 mRNA expression was not affected (Musaro et al 2001, Oliver et al 2005.…”
Section: Discussionsupporting
confidence: 81%
“…Modulation of the various components of this system appears to be important for the development of a compensatory hypertrophic response (1, 7,8,10,20,24,26,33,44). In animal studies, increased muscle loading has been shown to result in an upregulation of the expression of IGFBP-4 and downregulation of IGFBP-5 (7,25). The same pattern of changes was seen in these mRNAs in muscle samples from both the AB and SCI subjects in the present study (Fig.…”
Section: Discussionsupporting
confidence: 74%
“…In muscle, the IGF-I axis consists of locally expressed IGF-I and MGF, the type I IGF-I receptor, and a number of IGFBPs. Modulation of the various components of this system appears to be important for the development of a compensatory hypertrophic response (1, 7,8,10,20,24,26,33,44). In animal studies, increased muscle loading has been shown to result in an upregulation of the expression of IGFBP-4 and downregulation of IGFBP-5 (7,25).…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, IG-FBP-4, another inhibitor of IGFs, was up-regulated in the treated group. Of interest, a similar up-regulation of IG-FBP-4 has been observed in electrically stimulated rodent myotubes (Bayol et al, 2005) and stretched muscles (Awede et al, 1999) as well as during denervation in vivo (Bayol et al, 2000), indicating that IGFBP-4 expression is increased in response to both increased and decreased muscle activity. It has been proposed that IG-FBP-4 may protect cells from IGF overstimulation or allow the activation of alternate signaling pathways, which are inhibited by the IGFs (Jones and Clemmons, 1995).…”
Section: Increased Movement Differently Alters the Igf System In Slowsupporting
confidence: 54%
“…Studies in mammals have also shown that various factors, such as movement (Willis et al, 1998) and overloading of mature skeletal muscle (Awede et al, 1999), affect the regulation of the insulin-like growth factor (IGF) system. To date, there is relatively little research exploring the effects of stimulation-induced movement during mid-to-late embryonic development in vivo on the expression of genes associated with the IGF system.…”
Section: Introductionmentioning
confidence: 99%