Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds

Kim, Dong-Il; Lee, Tae-Kyun; Lim, Ig-Seob; Kim, Hwa; Lee, Young Choon; Kim, Cheorl-Ho

doi:10.1016/j.taap.2004.10.007

Cited by 55 publications

(33 citation statements)

References 38 publications

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“…The chemical composition of BZL101 is complex [29][30][31] and has been shown to contain several anticancer phytochemicals such as apigenin, luteolin and resveratrol, 29,32 that can disrupt multiple proliferative pathways. In addition, this herbal mixture was recently shown to contain several anticancer flavones, such as Wogonin, Baicalein and Baicalin, which have both cytostatic and cytotoxic activities in certain cultured cells and can inhibit tumor growth in vivo.…”

Section: Discussionmentioning

confidence: 99%

BZL101, a phytochemical extract from theScutellaria barbataplant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

Marconett

Morgenstern

Roman

et al. 2010

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 99%

BZL101, a phytochemical extract from theScutellaria barbataplant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

Marconett

Morgenstern

Roman

et al. 2010

Cancer Biology & Therapy

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“…The active compounds of Sophora flavescens AIT consist of alkaloids, flavones and aralosides (2). As a major quinolizindine alkaloid isolated from Sophora flavescens AIT, matrine possesses antitumor, antivirus, antioxidant and anti-inflammatory actions (1,(3)(4)(5). The anticancer effects of matrine were reported in murine hepatocellular carcinoma cells via regulating Bcl-2 and Bax expression (1).…”

Section: Introductionmentioning

confidence: 99%

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

Yang

Wang

et al. 2014

Molecular Medicine Reports

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Abstract. Matrine, an alkaloid isolated from the traditional Chinese medicine Sophora flavescens AIT has exhibited a number of therapeutic effects on cardiovascular and liver diseases. The purpose of the present study was to investigate whether matrine has a protective effect on heart failure in rats. Coronary artery ligation was used to induce a heart failure (CHF) model in rats. Four weeks following the procedure, the rats were treated with different doses of matrine for one month. Histopathological examination demonstrated that matrine treatment alleviated myocardial hypertrophy and cardiac fibrosis in failing hearts. Furthermore, matrine administration also inhibited the increase of plasma aspartate amino transferase, creatine phosphokinase and lactate dehydrogenase levels in CHF rats. The rats with heart failure exhibited a significant reduction in ejection fraction and fractional shortening, as well as an increase in the left ventricular end systolic dimension, and matrine attenuated this decline in heart function. Further investigation demonstrated that matrine treatment also inhibited the upregulation of Bax and increase in the Bcl-2 expression in the failing hearts. Furthermore, the upregulation of β3-adrenoreceptor (AR) and endothelial nitric oxide synthase proteins following heart failure were also attenuated by matrine. In conclusion, matrine had a preventive role in heart failure in rats at least in part by inhibiting myocardial apoptosis and the β3-AR pathway.

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“…Among these, flavones such as apigenin and luteolin are well-known to have anticancer activity (Chen et al, 2012;Kim et al 2005). Chen et al (2012) found that apigenin exhibited appreciable cytotoxic activity against erythroleukemia (K562), gastric cancer (MGC-803), promyelocytic leukemia (HL60), oral squamous cancer cells (KB) and neuroblastoma (SH-SY5Y).…”

Section: Introductionmentioning

confidence: 99%

“…Chen et al (2012) found that apigenin exhibited appreciable cytotoxic activity against erythroleukemia (K562), gastric cancer (MGC-803), promyelocytic leukemia (HL60), oral squamous cancer cells (KB) and neuroblastoma (SH-SY5Y). Luteolin was most effective against gastric cancer (MGC-803), promyelocytic leukemia (HL60), and neuroblastoma (SH-SY5Y), liver cancer (SMMC-7221) and colon cancer (SW480) (Kim et al, 2005). However, apigenin and luteolin were reportedly non-selective showing cytotoxicity to both human breast cancer cell line MDA-MB-231 as well as non-transformed breast cell line MCF10A (Chen et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research

Tao

Balunas

2016

Journal of Ethnopharmacology

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Ethnopharmacological relevance: Scutellaria barbata is a common herb in Traditional ChineseMedicine (TCM) most often used to treat cancer. S. barbata has been found to exhibit efficacy both in vitro and in vivo on a variety of cancer types. Similarly encouraging results have been shown in patients with metastatic breast cancer from Phase Ia and Ib clinical trials. This study aims to elucidate the current use of S. barbata by TCM practitioners and in current Western research. Materials and Methods:Semi-structured interviews were conducted with fifteen TCM practitioners in Beijing and Nanjing, China to understand their clinical use of S. barbata.Practitioners were also asked to comment on the future development of TCM using Western research methods and the potential for integration of the two types of medicine in clinical therapy. Statistical analyses were conducted to compare use of S. barbata by disease and in conjunction with other herbs.Results: Current Western research related to S. barbata is focused on cancer treatment, which corresponds to the most common use of S. barbata by TCM practitioners. Other common uses that practitioners reported included infection and inflammation, for which Beijing practitioners reported use of S. barbata more often than Nanjing practitioners (p < 0.05). Hedyotis diffusa was found to be the most commonly cited herb to pair with S. barbata for cancer treatment (p < 0.05).When compared to Western clinical trials of BZL101, an S. barbata extract, TCM practitioners reported using smaller doses of S. barbata in shorter durations, in combination with numerous other herbs with the goal to potentiate therapeutic efficacy and mitigate side effects. In addition, TCM practitioners repeatedly emphasized symptom differentiating as the key to achieving maximum therapeutic potential of S. barbata, a factor typically overlooked in Western research.

show abstract

Regulation of IGF-I production and proliferation of human leiomyomal smooth muscle cells by D. Don in vitro: isolation of flavonoids of apigenin and luteolin as acting compounds

Cited by 55 publications

References 38 publications

BZL101, a phytochemical extract from theScutellaria barbataplant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

BZL101, a phytochemical extract from theScutellaria barbataplant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

Current therapeutic role and medicinal potential of Scutellaria barbata in Traditional Chinese Medicine and Western research

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