Regulation of p53 under hypoxic and inflammatory conditions in periodontium

Memmert, Svenja; Gölz, Lina; Pütz, P; Jäger, Andreas; Deschner, James; Appel, T.; Baumgarten, Georg; Rath-Deschner, Birgit; Frede, Stilla; Götz, Werner

doi:10.1007/s00784-015-1679-x

Cited by 13 publications

(13 citation statements)

References 47 publications

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“…BAX induces the release of cytochrome c from mitochondria, thus activating caspase-3 and initiating apoptotic cell death [16]. Interestingly, our previous study on periodontal cells demonstrated increased p53 levels and reduced cell viability after stimulation of the cells with lipopolysaccharide from the periodontopathogen P. gingivalis [29], thus further emphasizing the crucial crosstalk between pro-inflammatory stimuli, p53 signaling, and manifestation of periodontitis.…”

Section: Discussionmentioning

confidence: 92%

Damage-regulated autophagy modulator 1 in oral inflammation and infection

et al. 2018

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Section: Discussionmentioning

confidence: 92%

Damage-regulated autophagy modulator 1 in oral inflammation and infection

et al. 2018

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“…Studies have suggested that the expression level of p53 in periodontal ligament cells is upregulated under hypoxic and inflammatory conditions. 42 Here, the p53 signaling pathway was associated with the upregulated genes both in PI vs. PIC and PD vs. PDC but not in PI vs. PD, which suggested that p53 may be a common pathway in the pathogenesis of peri-implantitis and periodontitis.…”

Section: The Upregulated Genes (Targets Of Lowmentioning

confidence: 67%

MicroRNA sequence and function analysis in peri‐implantitis and periodontitis: An animal study

Zhang

Yuan

Xue

et al. 2022

J of Periodontal Research

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Objective: To compare miRNA expression levels and predict relevant target genes and signaling pathways in peri-implantitis and periodontitis.Background: There are many differences between periodontitis and peri-implantitis.An understanding of the similarities and differences in the transcriptional patterns of these diseases, as well as the molecular mechanisms, is beneficial for the development of management strategies. Materials and methods:Rat models of periodontitis (PD, n = 6) and peri-implantitis (PI, n = 5) were established by ligation. Implantation without ligation (PIC, n = 5) and normal rats (PDC, n = 6) were used as controls. Micro-CT was used to confirm the successful establishment of the model. Gingiva was harvested for miRNA transcriptome sequencing, and the results were confirmed by qRT-PCR. miRNA target genes were predicted with miRTarBase. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed.Results: Sixty-nine miRNAs were differentially expressed in PI vs. PD, 105 were differentially expressed in PI vs. PIC, and 70 were differentially expressed in PD vs. PDC (log 2 FC ≥1 and padj <0.05). The upregulated genes in all three comparisons were mostly involved in the biological process response to stimulus, whereas most of the downregulated genes were involved in nervous system development (p < .01).The upregulated genes in PI vs. PD and PI vs. PIC were involved in Toll-like receptor signaling and RIG-I-like signaling. The upregulated genes in PI vs. PD were involved in T-and B-cell receptor signaling, apoptosis, and osteoclast differentiation. Focal adhesion was downregulated in all three comparisons, and adherens junction was downregulated in PI vs. PD and PD vs. PDC (p < .1). Conclusion:This study showed differences in the miRNA expression profiles between peri-implantitis and periodontitis and annotated the possible target genes and molecular mechanisms; this study could lay a foundation for the development of management strategies.

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“…One of the most recognized genomic alterations in PD is that of the TP53 gene encoding the p53 tumor suppressor protein, regarded as the guardian of the genome . When p53 is upregulated it has destructive effects that compromise periodontal integrity, suggesting its contribution to tumourigenesis [ 32 ]. Interestingly, the frequency of TP53 gene expression in neoplastic conditions is similar to that seen in PD.…”

Section: Periodontal Pathogens and The Host Responses: War And Trucementioning

confidence: 99%

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

Elebyary

Barbour

Fine

et al. 2021

Front. Oral. Health

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Periodontitis (PD) is increasingly considered to interact with and promote a number of inflammatory diseases, including cancer. In the case of oral squamous cell carcinoma (OSCC) the local inflammatory response associated with PD is capable of triggering altered cellular events that can promote cancer cell invasion and proliferation of existing primary oral carcinomas as well as supporting the seeding of metastatic tumor cells into the gingival tissue giving rise to secondary tumors. Both the immune and stromal components of the periodontium exhibit phenotypic alterations and functional differences during PD that result in a microenvironment that favors cancer progression. The inflammatory milieu in PD is ideal for cancer cell seeding, migration, proliferation and immune escape. Understanding the interactions governing this attenuated anti-tumor immune response is vital to unveil unexplored preventive or therapeutic possibilities. Here we review the many commonalities between the oral-inflammatory microenvironment in PD and oral-inflammatory responses that are associated with OSCC progression, and how these conditions can act to promote and sustain the hallmarks of cancer.

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Regulation of p53 under hypoxic and inflammatory conditions in periodontium

Abstract: Upregulation of p53 may promote the destruction of periodontal integrity. A possible relationship with carcinogenesis may be discussed.

Cited by 13 publications

References 47 publications

Damage-regulated autophagy modulator 1 in oral inflammation and infection

Damage-regulated autophagy modulator 1 in oral inflammation and infection

MicroRNA sequence and function analysis in peri‐implantitis and periodontitis: An animal study

The Crossroads of Periodontitis and Oral Squamous Cell Carcinoma: Immune Implications and Tumor Promoting Capacities

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