Regulation of Sleep by Insulin-like Peptide System in<i>Drosophila melanogaster</i>

Xia, Cong; Wang, Haili; Liu, Zhenxing; He, Chun‐Xia; An, Chunju; Zhao, Zhangwu

doi:10.5665/sleep.4816

Cited by 76 publications

(60 citation statements)

References 43 publications

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“…In bumble bees and other insects, expression of insulin signalling pathway genes is an important regulator of diapause, and can be influenced by the cold temperatures experienced during queen overwintering (Amsalem, Galbraith, Cnaani, Teal, & Grozinger, ). However, insulin signalling is involved in other processes such as the sleep cycle, longevity, and sexual maturation, any of which may respond to aspects of seasonality that correlate with Isothermality (Cong et al, ; Post et al, ) . Although limited in number, other studies of montane adaptation in bees have suggested that the strongest signatures of selection may be in genes associated with olfaction, foraging, and reproduction (Montero‐Mendieta et al, ; Wallberg et al, ).…”

Section: Discussionmentioning

confidence: 99%

Local adaptation across a complex bioclimatic landscape in two montane bumble bee species

et al. 2020

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Understanding evolutionary responses to variation in temperature and precipitation across species ranges is of fundamental interest given ongoing climate change. The importance of temperature and precipitation for multiple aspects of bumble bee (Bombus) biology, combined with large geographic ranges that expose populations to diverse environmental pressures, make these insects well‐suited for studying local adaptation. Here, we analyzed genome‐wide sequence data from two widespread bumble bees, Bombus vosnesenskii and Bombus vancouverensis, using multiple environmental association analysis methods to investigate climate adaptation across latitude and altitude. The strongest signatures of selection were observed in B. vancouverensis, but despite unique responses between species for most loci, we detected several shared responses. Genes relating to neural and neuromuscular function and ion transport were especially evident with respect to temperature variables, while genes relating to cuticle formation, tracheal and respiratory system development, and homeostasis were associated with precipitation variables. Our data thus suggest that adaptive responses for tolerating abiotic variation are likely to be complex, but that several parallels among species can emerge even for these complex traits and landscapes. Results provide the framework for future work into mechanisms of thermal and desiccation tolerance in bumble bees and a set of genomic targets that might be monitored for future conservation efforts.

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Section: Discussionmentioning

confidence: 99%

Local adaptation across a complex bioclimatic landscape in two montane bumble bee species

et al. 2020

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“…The PDF + ventral lateral circadian neurons (LN v s) comprise a wake-promoting network that may potentially include NPF release from or feedback control via NPFR + to these cells (Parisky et al, 2008, Chung et al, 2009, Hermann et al, 2012, Kim et al, 2013)). The NPF + LN d circadian neurons, which may receive wake-promoting signals from the PDF + LN v s, have been previously implicated in the control of both starvation-induced sleep suppression and night time sleep regulation (Keene et al, 2010, Cong et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior

et al. 2017

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Summary Proper regulation of sleep-wake behavior and feeding is essential for organismal health and survival. While previous studies have isolated discrete neural loci and substrates important for either sleep or feeding, how the brain is organized to coordinate both processes with respect to one another remains poorly understood. Here, we provide evidence that the Drosophila Neuropeptide F (NPF) network forms a critical component of both adult sleep and feeding regulation. Activation of NPF signaling in the brain promotes wakefulness and adult feeding, likely through its cognate receptor NPFR. Flies carrying a loss-of-function NPF allele do not suppress sleep following prolonged starvation conditions, suggesting that NPF acts as a hunger signal to keep the animal awake. NPF-expressing cells, specifically those expressing the circadian photoreceptor cryptochrome, are largely responsible for changes to sleep behavior caused by NPF neuron activation, but not feeding, demonstrating that different NPF neurons separately drive wakefulness and hunger.

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“…The IPCs have not been implicated in the direct control of circadian rest:activity rhythms, although insulin appears to act during development to modulate rest:activity rhythms in a Drosophila disease model (Cong et al 2015;Monyak et al 2016). In mammals, on the other hand, pancreatic β cells contain molecular clocks, and rhythmic secretion of insulin appears to be important for metabolic homeostasis (Van Cauter et al 1991;Boden et al 1996;Peschke and Peschke 1998).…”

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confidence: 99%

Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells

et al. 2016

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Circadian clocks regulate much of behavior and physiology, but the mechanisms by which they do so remain poorly understood. While cyclic gene expression is thought to underlie metabolic rhythms, little is known about cycles in cellular physiology. We found that Drosophila insulin-producing cells (IPCs), which are located in the pars intercerebralis and lack an autonomous circadian clock, are functionally connected to the central circadian clock circuit via DN1 neurons. Insulin mediates circadian output by regulating the rhythmic expression of a metabolic gene (sxe2) in the fat body. Patch clamp electrophysiology reveals that IPCs display circadian clock-regulated daily rhythms in firing event frequency and bursting proportion under light:dark conditions. The activity of IPCs and the rhythmic expression of sxe2 are additionally regulated by feeding, as demonstrated by night feeding-induced changes in IPC firing characteristics and sxe2 levels in the fat body. These findings indicate circuit-level regulation of metabolism by clock cells in Drosophila and support a role for the pars intercerebralis in integrating circadian control of behavior and physiology.

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Regulation of Sleep by Insulin-like Peptide System inDrosophila melanogaster

Abstract: Taken together, the results indicate that the Drosophila insulin-like peptide system is a crucial regulator of sleep.

Cited by 76 publications

References 43 publications

Local adaptation across a complex bioclimatic landscape in two montane bumble bee species

Local adaptation across a complex bioclimatic landscape in two montane bumble bee species

Drosophila Neuropeptide F Signaling Independently Regulates Feeding and Sleep-Wake Behavior

Circadian and feeding cues integrate to drive rhythms of physiology in Drosophila insulin-producing cells

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