Regulation of the Alternative NF-κb Pathway and Its Role in Cancer

Vallabhapurapu, Subrahmanya D.; Pagolu, Koteswara Rao; Sivakumar, V.

doi:10.4172/1948-5956.1000e122

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…NF‐κB subunits participate in various biological processes and play critical roles in cell growth and survival, and immune and inflammatory responses . Aberrant NF‐κB activities are involved in many inflammatory diseases, leukemia, and solid tumors …”

Section: Introductionmentioning

confidence: 99%

“…4 Aberrant NF-κB activities are involved in many inflammatory diseases, leukemia, and solid tumors. [5][6][7] In the alternative NF-κB signaling pathway, the central players are RelB and p100/p52. 4 The signaling pathway is activated by IκB kinase α (IKK)α-dependent processing of the inhibitory NF-κB2/p100 protein to p52, resulting in transcriptionally activated RelB/p52 hetero-dimers.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic significance of RelB overexpression in non‐small cell lung cancer patients

Qin

Zhou

et al. 2016

Thoracic Cancer

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BackgroundLung cancer is a major public health issue in most countries, including China. The expression of RelB is associated with poor prognosis in diverse cancers. However, whether RelB expression could be an indicator of poor prognosis in non‐small cell lung cancer (NSCLC) is still unclear.MethodsThe expression of RelB in NSCLC tumor tissue and adjacent non‐neoplastic tissues were examined by immunohistochemistry. Chi‐square or two‐tailed Fisher's exact tests were used to analyze possible associations between qualitative clinicopathological variables and RelB expression. Kaplan–Meier analysis and a Cox regression model were employed to determine independent prognostic factors.ResultsThe expression of RelB was increased in tumor tissue compared with adjacent non‐neoplastic tissue in NSCLC patients. High RelB expression was significantly correlated with degree of differentiation (P = 0.023), depth of tumor invasion (P < 0.001), lymph node metastasis (P = 0.017), distant metastases (P = 0.004), and tumor node metastasis stage (P < 0.001) in patients with NSCLC. NSCLC patients with high RelB expression had significantly shorter overall survival than those with low RelB expression (P < 0.001). Our results indicate that high RelB expression is an independent prognostic factor for patients with NSCLC (P < 0.001).ConclusionsHigh RelB expression could provide a basis for judgment of prognosis in patients with NSCLC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic significance of RelB overexpression in non‐small cell lung cancer patients

Qin

Zhou

et al. 2016

Thoracic Cancer

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“…However, both IKKα and the TRAF family member-associated NF-κB activator-binding kinase 1 phosphorylate NIK leading to the induction of its degradation. As a result, the non-canonical NF-κB signaling is abolished (Vallabhapurapu et al 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Manipulation of Non-canonical NF-κB Signaling by Non-oncogenic Viruses

Struzik

Szulc-Dąbrowska

2018

Arch. Immunol. Ther. Exp.

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Nuclear factor (NF)-κB is a major regulator of antiviral response. Viral pathogens exploit NF-κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical (classical) NF-κB signaling, which regulates innate immune response, cell survival and inflammation, is often manipulated by viral pathogens that can counteract antiviral response. Oncogenic viruses can modulate not only canonical, but also non-canonical (alternative) NF-κB activation pathways. The non-canonical NF-κB signaling is responsible for adaptive immunity and plays a role in lymphoid organogenesis, B cell development, as well as bone metabolism. Thus, non-canonical NF-κB activation has been linked to lymphoid malignancies. However, some data strongly suggest that the non-canonical NF-κB activation pathway may also function in innate immunity and is modulated by certain non-oncogenic viruses. Collectively, these findings show the importance of studying the impact of different groups of viral pathogens on alternative NF-κB activation. This mini-review focuses on the influence of non-oncogenic viruses on the components of non-canonical NF-κB signaling.

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Regulation of the Alternative NF-κb Pathway and Its Role in Cancer

Cited by 2 publications

References 26 publications

Prognostic significance of RelB overexpression in non‐small cell lung cancer patients

Prognostic significance of RelB overexpression in non‐small cell lung cancer patients

Manipulation of Non-canonical NF-κB Signaling by Non-oncogenic Viruses

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