Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium

Brañes, María C.; Morales, Bernardo; Ríos, Mariana; Villalón, Manuel

doi:10.1152/ajpcell.00420.2003

Cited by 62 publications

(51 citation statements)

References 53 publications

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“…The increased oviductal fluid secretion is mostly due to the increased water availability, which is related to the function of the transmembrane water transport proteins, aquaporins (AQPs). In rats, expression of Aqp5, Aqp8 and Aqp9 is regulated by both E 2 and P 4 (Branes et al 2005). These findings indicate that E 2 , P 4 and prolactin play a major role in fluid production in the oviduct.…”

Section: Tubal Fluid Flowmentioning

confidence: 74%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

210

191

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Animal oviducts and human Fallopian tubes are a part of the female reproductive tract that hosts fertilization and pre-implantation development of the embryo. With an increasing understanding of roles of the oviduct at the cellular and molecular levels, current research signifies the importance of the oviduct on naturally conceived fertilization and pre-implantation embryo development. This review highlights the physiological conditions within the oviduct during fertilization, environmental regulation, oviductal fluid composition and its role in protecting embryos and supplying nutrients. Finally, the review compares different aspects of naturally occurring fertilization and assisted reproductive technology (ART)-achieved fertilization and embryo development, giving insight into potential areas for improvement in this technology.

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Section: Tubal Fluid Flowmentioning

confidence: 74%

Oviduct: roles in fertilization and early embryo development

Winuthayanon

2017

Journal of Endocrinology

210

191

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“…In addition, studies found that AQP9 was the only AQP localized after ovariectomy and administration of progesterone and estradiol (Branes et al, 2005). These results indicate that AQPs function not only in water transport but also in the absorption or secretion of luminal fluid metabolites, thus maintaining a suitable environment for reproductive functions (Kenny et al, 2002).…”

Section: Female Reproductive Systemmentioning

confidence: 82%

Review Structure, function, and localization of aquaporins: their possible implications on gamete cryopreservation

Sales¹,

Lobo²,

Carvalho³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. The discovery of water channels (aquaporins, AQPs) was a landmark event for the clarification of water transport through the plasma membrane. AQPs belong to a family of intrinsic membrane proteins that act as selective channels for water and for solutes such as glycerol and urea. AQPs were found in different tissues and organs, including male and female reproductive systems. In the swine female reproductive system, the AQPs were localized in the uterus, oviduct, and ovary, as well as in the granulosa cells from primordial follicles. Knowing the involvement of AQPs with the male and female germ cells, as well as their acknowledged role in transporting water through the plasma membrane, the research of these proteins in cryopreservation processes becomes essential. Thus, this review aims to describe the structure and function of AQPs in membranes, highlighting their role 6719 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 12 (4): 6718-6732 (2013) Overview and role of aquaporins on gamete cryopreservation in the reproductive system (male and female). We also discuss the involvement of AQPs in cryopreservation, focusing on the effect and importance of these proteins on the rates of vitrification protocols for preantral follicles present in the ovarian tissue of domestic mammals.

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“…In the literature thus far, there are two reports pertaining to AQP localization in oviductal tissues. Branes et al (2005) showed by IHC the expression of AQP5, AQP8, and AQP9 in the epithelial cells of the rat oviduct. In turn, Gannon et al (2000) found AQP1 labeling in the innermost and the inner cells of the circular muscular layer of the rat oviduct.…”

Section: Aqps In Oviductmentioning

confidence: 96%

Immunolocalization of Aquaporin 1, 5, and 9 in the Female Pig Reproductive System

Skowroński

Kwon

Nielsen

2008

J Histochem Cytochem.

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(SN) S U M M A R Y Thirteen mammalian aquaporin (AQP) isoforms have been identified, and they have a unique tissue-specific pattern of expression. AQPs have been documented in the reproductive system of both male and female humans, rats, and mice. However, tissue expression and cellular and subcellular localization of AQPs are unknown in the female reproductive system of pigs. In this study, AQP1 immunoreactivity was detected in the capillary endothelium of the ovary. Distinct immunolabeling of capillary endothelium was also observed in the oviduct and uterus. AQP5 was expressed in flattened follicle cells of primordial follicles, granulosa cells of developing ovarian follicles, and muscle cells of the oviduct and uterus. Staining of AQP5 was also observed in the epithelial cells of the oviduct and uterine epithelium. AQP9 immunoreactivity was observed in granulosa cells of developing follicles. AQP9 was also localized in the luminal epithelial cells of the oviduct and uterine epithelia cells. This is, to our knowledge, the first study that shows tissue expression and cellular and subcellular localization of AQPs in the reproductive system of the female pig. Moreover, these results suggest that several subtypes of the AQPs (AQP1, 5, and 9) are involved in regulation of water homeostasis in the reproductive system of gilts. The first confirmation of AQP in the female reproductive system was obtained by isolating and sequencing the cDNA encoding a water channel from the human uterus (Li et al. 1994). Afterward, Li et al. (1997) found AQP1 mRNA in the rat uterus. To date, based on protein expression, at least nine AQP isoforms have been shown to be expressed in the female reproductive system of humans, rats, and mice (reviewed by Huang et al. 2006). Their specific expression pattern suggests that they play a role in water movement between the intraluminal, interstitial, and capillary compartments. There is also evidence indicating that ovarian steroid can regulate the expression of several AQPs (Jablonski et al. 2003;Branes et al. 2005;Lindsay and Murphy 2006). Nevertheless, data concerning the expression and role of AQPs in female reproductive tissues are still very limited and not available in relation to farm animals.

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Regulation of the immunoexpression of aquaporin 9 by ovarian hormones in the rat oviductal epithelium

Cited by 62 publications

References 53 publications

Oviduct: roles in fertilization and early embryo development

Oviduct: roles in fertilization and early embryo development

Review Structure, function, and localization of aquaporins: their possible implications on gamete cryopreservation

Immunolocalization of Aquaporin 1, 5, and 9 in the Female Pig Reproductive System

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