The article presents the results of the analysis of hygienic normative base and hygienic assessment of the daily regime and lifestyle of students of Omsk State Medical University taking into account the actual educational process (based on the results of questionnaire survey of 1204 students of 1–6 courses of all faculties). It was established that the lifestyle and daily routine of medical students is characterized by insufficient duration of night sleep (7 % — slept 8 or more hours) and motor activity (75 % of students move less than 1 hour a day during the session) in combination with high duration of computer and gadget use (90.5 % of students spend more than 170 minutes a day with screens), unsatisfactory meal frequency (25 % — 1–2 times a day), additional time spent on part-time work and pendulum migration (75 % — up to 2–3 hours). Methods of hygienic evaluation of the study of daily pendulum migration of students and calculation of the necessary duration of breaks between classes for their use in the course of drawing up the educational schedule in higher education institution and hygienic evaluation during the examination of the schedule have been proposed. The essential conditioning of students’ lifestyle and daily regimen by the peculiarities of the educational process in the following aspects has been proved: 1) the difficulty of learning, depending on the course, 2) dependence on the period of the academic year — semester, session, vacations and weekends, 3) the large distance between the educational buildings of the university, which implies an increase in the pendulum migration of students, time for moving and reduced opportunities for adequate sleep and rest. Based on the conducted research, a number of clarifications of hygienic regulatory framework and measures to optimize the educational process of a medical university in order to comply with a healthy lifestyle and daily regimen, to preserve the health of students can be proposed. When drawing up the curriculum, it is necessary to take into account the difficulty of academic disciplines and strive for a more even distribution of the study load.