Regulatory landscape of dietary supplements and herbal medicines from a global perspective

Thakkar, Shraddha; Anklam, Elke; Xu, Alexander M.; Ulberth, Franz; Li, Jing; Li, Bo; Hugas, Marta; Sarma, Nandakumara D.; Crerar, Scott; Swift, Sibyl N.; Hakamatsuka, Takashi; Curtui, Valeriu; Yan, William; Geng, Xin; Slikker, William; Tong, Weida

doi:10.1016/j.yrtph.2020.104647

Cited by 143 publications

(143 citation statements)

References 11 publications

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“…In the last years, the number of individuals assuming dietary supplements has been steadily increased worldwide [ 90 , 91 ]. Reasons for dietary supplements’ use widely varies across the countries: in Europe, it is just limited to general health and well-being, while other countries permit use for medicinal purposes [ 92 ].…”

Section: Discussionmentioning

confidence: 99%

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

et al. 2020

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Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA and 2294 assigned to placebo. A meta-analysis of extracted data suggested that supplementation with ALA was not associated with an increased risk of any treatment-emergent adverse event (all p > 0.05). ALA supplementation was safe, even in subsets of studies categorized according to smoking habit, cardiovascular disease, presence of diabetes, pregnancy status, neurological disorders, rheumatic affections, severe renal impairment, and status of children/adolescents at baseline.

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Section: Discussionmentioning

confidence: 99%

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

et al. 2020

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“…the Mifflin-San Geor formula was used [17][18], which allows to formalize the norms of calorie content taking into account gender, weight, height, age. x To develop a support system for creating an individual diet plan, it is necessary to consider the basis of the diet for athletes [19]:…”

Section: Methodsmentioning

confidence: 99%

Decision support system for individual athlete’s diet based on optimization modeling’ development

2020

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The article discusses the main areas of information technology tools application in the training of athletes, analyzes the types of expert systems that can be applied for this subject area, indicating the features of their use, including the tasks of supporting the plans preparation for individual diets of athletes. The formulated mathematical model is considered as a decision-making model in an optimization formulation for seeking the optimal ratio of food components from the space of admissible decisions of the various food products ratio. The recommendations regarding the daily needs of athletes in the necessary vital components for various sports activity categories, considering the norms of daily calorie intake in accordance with the Mifflin-San Geor formula, indicating the maximum norms of proteins, fats, carbohydrates, are analyzed. A mathematical model is presented in an optimization formulation from the class of discrete programming, on which the developed intelligent decision support system is based. The implementation components of the software system in the pseudocode format and examples of the implementation of the model for the formation of individual diet plans in the optimization setting are presented. The developed software package can be used for automatic generation of basic recommendations for the proposal of individual diets as an auxiliary means of supporting the activities of a dietitian to find the optimal plan in terms of maximizing individual preferences for food in the area of permissible values for the restrictions on the type of sports activities and the maximum norms of food components.

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“…Under the Japanese and Chinese Food Safety Law, the healthy foods including foods for specified health uses/function claims are classified as "supplements", whereas traditional Chinese medicine (e.g., Kampo medicine) is classified as "complementary medicines". In Canada, natural health products including herbal medicine, homeopathy, and traditional medicine are classified as "complementary medicines" [68].…”

Section: Data Applications and Influencesmentioning

confidence: 99%

“…This approach integrates the areas of developmental and reproductive toxicity, carcinogenicity, genotoxicity, and kinetics [80]. Countries like Australia, Canada, China, and Japan have proposed that incorporating new technologies such as DNA barcoding, an omics-based approach, blockchain, in silico tools, and advanced analytics techniques may improve guidelines on safety evaluation and quality control of dietary supplements [68].DNA barcoding is a powerful technique which detects deceptive dietary supplements [68]. In North America, herbal dietary supplement fraud may occur due to product substitution with cheap/contaminated species and fraudulent labeling [81].…”

Section: Data Applications and Influencesmentioning

confidence: 99%

“…In North America, herbal dietary supplement fraud may occur due to product substitution with cheap/contaminated species and fraudulent labeling [81]. An omics-based analytical approach is a novel tool for assessing the safety of dietary supplements such as botanical and herbal products [68]. Transcriptomics is among the most used omics technologies in dietary supplements research.…”

Section: Data Applications and Influencesmentioning

confidence: 99%

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Supplements for Smoking-Related Lung Diseases

Alsharairi¹

2021

Encyclopedia

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Supplements for smoking-related lung diseases are considered as nonfood products and thought to improve health. Multivitamins and antioxidants are the most commonly dietary supplements used by cancer and asthma patients. There are currently no clear regulatory guidelines that include dietary supplements and their effect on lung cancer and asthma patients, particularly in smokers. Several countries have taken steps to overcome challenges in regulating dietary supplements in the marketplace. These challenges include inadequate assurance of safety/efficacy, inaccuracy of product labeling, misleading health claims, and lack of analytical techniques for dietary supplements. There is a need to establish standards and regulation of dietary supplement use in patients with lung cancer and asthma. The aim of this entry is to expand knowledge on dietary supplements use and smoking-related lung diseases (lung cancer and asthma).

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Regulatory landscape of dietary supplements and herbal medicines from a global perspective

Cited by 143 publications

References 11 publications

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies

Decision support system for individual athlete’s diet based on optimization modeling’ development

Supplements for Smoking-Related Lung Diseases

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