Reinforcement of Polycaprolactone/Chitosan with Nanoclay and Controlled Release of Curcumin for Wound Dressing

Abstract

A novel clay-reinforced polycaprolactone/chitosan/curcumin (PCl/CS/Clay/Cur) composite film was fabricated in this study. The prepared Cur-loading composite films were characterized with attenuated total reflection Fourier transformed infrared spectroscopy, scanning electron microscopy, atomic force microscopy, water contact angle, differential scanning calorimetry, thermogravimetric analysis, and X-ray diffraction, and the results showed good dispersion of clay in the composite films. The addition of nanoclay was found to significantly increase the tensile strength. Also, the clay-enhanced drug-loading films exhibited better controlled-release profiles of Cur than those membranes without clay. Skin disinfection test demonstrated that the curcumin-loaded film could protect wound from bacterial infection. Cytotoxicity analysis proved the good biocompatibility of the composite films. The clay-enhanced Cur-loading films might be promising candidates for wound care.

Three-Dimensional Printing of Curcumin-Loaded Biodegradable and Flexible Scaffold for Intracranial Therapy of Glioblastoma Multiforme

“…To investigate potential interactions of curcumin with PCL matrix, the PA-FTIR spectroscopy was performed on pure curcumin powder, blank, and curcumin-loaded PCL scaffolds (7%, w / w ) ( Figure 5 ). The PCL spectra displayed typical FT-IR peaks at ~2947–2866, 1730, 1471–1367, and 1294 cm −1 , attributed to stretching vibrations of –CH 2 , stretching vibrations –C=O, bending vibrations of –CH 2 , and stretching vibrations of –COO, respectively [ 34 , 35 ]. Curcumin spectra displayed strong absorbances at 1603 and 1633 cm −1 attributed to C=C and –C=O of the aromatic rings [ 34 , 36 ].…”

“…The PCL spectra displayed typical FT-IR peaks at ~2947–2866, 1730, 1471–1367, and 1294 cm −1 , attributed to stretching vibrations of –CH 2 , stretching vibrations –C=O, bending vibrations of –CH 2 , and stretching vibrations of –COO, respectively [ 34 , 35 ]. Curcumin spectra displayed strong absorbances at 1603 and 1633 cm −1 attributed to C=C and –C=O of the aromatic rings [ 34 , 36 ]. The curcumin-loaded scaffold spectra were dominated by PCL peaks with weak curcumin absorptions at 1602 and 1627 cm −1 .…”

“…The solid-state of curcumin within the PCL matrix was characterised by XRD. As illustrated in Figure 6 , the X-ray patterns of the blank scaffold showed typical peaks of PCL at 21.66° and 23.92° [ 37 , 38 ], while pure curcumin exhibited a series of intense and sharp 2θ peaks at 7.90°, 8.98°, 17.20°, 21.22°, 23.32°, and 24.76° [ 34 ], indicating that pure curcumin was highly crystalline. Drug-loaded scaffolds did not display any sharp peaks corresponding to curcumin, indicating that curcumin was predominantly dispersed in the PCL matrix amorphously, and the particles on the scaffold surface ( Figure 4 d) was either drug-polymer dispersion or the amount of drug crystalline was below the sensitivity of detection.…”

A Critical Review on Polymeric Biomaterials for Biomedical Applications

“…Natural polymers, like collagen, chitosan, carboxymethyl cellulose, and alginate, are the most studied for film preparation and their application as wound dressing materials [ 26 , 27 , 30 , 31 ]. Synthetic polymers, like PVA, PEG, and PCL, have been reported for their potential application as wound dressing materials [ 30 , 32 , 33 ]. Natural and synthetic polymers are used as individual components or prepared as a composite to improve their mechanical properties.…”

Natural products and phytochemical nanoformulations targeting mitochondria in oncotherapy: an updated review on resveratrol

“…Nowadays, the application of naturally occurring compounds has undergone an increase for management of various chronic diseases [115,116]. This is due to the great pharmacological impacts of plant-derived chemicals that have made them appropriate options in the treatment of a variety of disorders such as cancer, diabetes [117], cardiovascular diseases [118], autoimmune diseases [119] and infectious diseases [120]. There have been efforts to reveal the underlying mechanism of action of these agents [3,121].…”