Online learning prefers to use electronic teaching materials, one of the teaching materials used is e-modules as a learning resource that can improve students’ abilities. This form of inquisition is oriented to R&D (Research & Development) with the application of the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). Research for implementation of e-module based using pre-experiment design with One Group Pretest-Posttest Design. The sample selection was done by purposive sampling technique, the samples studied were students of SMA Negeri 1 Tanjungbalai as many as 32 students. The instruments used are the BSNP questionnaire and thedescription test High Order Thinking Skill (HOTS). The results showed that the development of SETS-based e-modules with the PjBL model on colloidal learning: (1) the average feasibility of developing e-modules for all BSNP criteria was eligible (content feasibility = 3.54, language eligibility = 3.59, presentation feasibility = 3.84 and the feasibility of graphics = 3.68, then the e-module is feasible to use, and (2) its use has an effect on increasing High Order Thinking Skill students’(HOTS) (with an N-gain of 0.44).