Relação entre Velocidade de Onda de Pulso e Biomarcadores Cardiovasculares em Pacientes com Fatores de Risco

Fagundes, Rayne Ramos; Vitorino, Priscila Valverde Oliveira; Lelis, Ellen de Souza; Jardim, Paulo César Brandão Veiga; Souza, Amaury de; Jardim, Thiago de Souza Veiga; Cunha, Pedro; Barroso, Weimar Kunz Sebba

doi:10.36660/abc.20190348

Cited by 7 publications

(6 citation statements)

References 43 publications

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“…Our study revealed that patients with carotid plaques had higher levels of aortic PWV (mean 1.54 m/s) and IMT (mean 7.653 mm), while their EF (mean 57.6%) and triglycerides (mean 101.8 mg/dl) were significantly lower compared to non-carotid plaques group. In agreement with our result, a study by Fagundes et al (16) on individuals with DM, dyslipidemia, pre-hypertension, or hypertension investigated the connection between PWV and indicators of structural alterations in the carotid arteries and left ventricle. The results showed that patients with carotid plaque had a significantly higher PWV with a p-value of less than 0.0001*.…”

Section: Discussionsupporting

confidence: 93%

The Prevalence of Valvular and Vascular Calcifications in Prevalent Hemodialysis Patients

2024

The Egyptian Journal of Hospital Medicine

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Background: Patients with chronic kidney disease (CKD) are likely to get valve calcification 10-20 years earlier than the normal population secondary to uremia. This condition is typically diagnosed through transthoracic echocardiography. Vascular calcification resulted in arterial stiffness and an increase in pulse wave velocity (PWV) in large elastic-type arteries. The intima-media complex acts as a stand-in marker for atherosclerosis and is where lipids are deposited during plaque development. Objective: This study aimed to estimate the prevalence of valvular and vascular calcifications in hemodialysis patients at

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Section: Discussionsupporting

confidence: 93%

The Prevalence of Valvular and Vascular Calcifications in Prevalent Hemodialysis Patients

2024

The Egyptian Journal of Hospital Medicine

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“…In the present study, the estimation of PWV was based on the Dyna Mapa AOP® oscillometric device based on its advantages and accessibility in our community ( 12 , 14 , 15 ). Besides it, there is a series of longitudinal studies showing a good correlation with target organ lesions and cardiovascular events with oscillometric devices ( 20 – 22 ), when compared to the gold standard noninvasive method of carotid-femoral tonometry ( 15 ). The differences observed between our data and the study by Oliveira et al ( 12 ) could be related, at least partially, by regional and ethnical variations in the Brazilian population ( 23 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

The usefulness of SAGE score in predicting high pulse wave velocity in hypertensive patients: a retrospective cohort study

Pereira,

Chagas,

Barbosa

et al. 2024

Front. Cardiovasc. Med.

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IntroductionAortic stiffness assessed by pulse wave velocity (PWV) is an important predictor to evaluate the risk of hypertensive patients. However, it is underutilized in clinical practice. We aimed to identify the optimal cutoff SAGE score that would indicate a risk PWV ≥ 10 m/s in Brazilian ambulatory hypertensive patients.Materials and methodsA retrospective cohort study. Patients underwent central blood pressure measurement using a validated oscillometric device from August 2020 to December 2021. A ROC curve was constructed using the Youden statistic to define the best score to identify those at high risk for PWV ≥ 10 m/s.ResultsA total of 212 hypertensive individuals were selected. The mean age was 64.0 ± 12.4 years and 57.5% were female. The following comorbidities were present: overweight (47.6%), obesity (34.3%), and diabetes (25.0%). Most of the sample (68.9%) had PWV < 10 m/s. According to Youden's statistic, a cutoff point of 6 provided the optimal combination of sensitivity and specificity for identifying patients with a PWV ≥ 10 m/s. This cutoff achieved sensitivity of 97.0%, and specificity of 82.9%. In clinical practice, however, a cutoff point of 7 (where score values of at least 7 were considered to indicate high risk) had a positive likelihood ratio of 8.2 and a negative likelihood ration of 0.346, making this the ideal choice by accurately excluding patients who are less likely to have PWV ≥ 10 m/s.ConclusionA SAGE score ≥7 identified Brazilian hypertensive patients with a high risk of PWV ≥ 10 m/s.

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“…Therefore, AH treatment guided by central BP parameters has the potential to show greater effectiveness in preventing or even regressing stiffness and TOD when compared to the conventional strategy ( 18 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological treatment of hypertension guided by peripheral or central blood pressure: a comparison between the two strategies

Guimarães Filho,

de Oliveira Vitorino,

Inuzuka

et al. 2023

Front. Cardiovasc. Med.

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BackgroundArterial hypertension treatment guided by central blood pressures (CPB) rather than peripheral blood pressures (PBP) measurement has the potential to show greater effectiveness in preventing or even regressing stiffness and target organ damage (TOD).ObjectiveThis study aimed to compare the parameters of CBP and PBP measurements, arterial stiffness, TOD and renal profile in patients with anti-hypertensive treatment guided by CBP or PBP targets.MethodsA randomized clinical trial was conducted in central group (CG) and peripheral group (PG). Patients were randomized, evaluated every 3 months for BP and antihypertensive adjustments during a one-year follow up. The procedures in V1 and V5: anthropometric assessment; CBP/PBP measurements, carotid ultrasound; echocardiography; laboratory tests. Paired and unpaired t-tests and the χ2 were used (significance level: 5%).ResultsThe study evaluated 59 participants (30CG/29PG). The augmentation index (AIx) was higher in the CG (27.3% vs. 20.3%, p = 0.041). Intergroup analysis has found central diastolic BP lower in the CG (78.9 vs. 84.3 mmHg, p = 0.024) and the Alx difference between groups ceased to exist after a one-year follow-up. Intragroup comparisons, after intervention, showed a lower frequency of changed PWV (p < 0.001) and LVMI (p = 0.018) in the CG. The PG showed a higher frequency of changed PWV (p < 0.001) and LVMI (p = 0.003).ConclusionThe intervention guided by central BP reduced the central diastolic BP and AIx compared to the PG. There was a reduction in the frequency of changed PWV and LVMI in the CG.

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Relação entre Velocidade de Onda de Pulso e Biomarcadores Cardiovasculares em Pacientes com Fatores de Risco

Cited by 7 publications

References 43 publications

The Prevalence of Valvular and Vascular Calcifications in Prevalent Hemodialysis Patients

The Prevalence of Valvular and Vascular Calcifications in Prevalent Hemodialysis Patients

The usefulness of SAGE score in predicting high pulse wave velocity in hypertensive patients: a retrospective cohort study

Pharmacological treatment of hypertension guided by peripheral or central blood pressure: a comparison between the two strategies

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