Relapsing Polychondritis

Chopra, Ratnesh; Chaudhary, Nida; Kay, Jonathan

doi:10.1016/j.rdc.2013.03.002

Cited by 52 publications

(53 citation statements)

References 63 publications

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“…22 Relapsing polychondritis is a rare autoimmune disorder characterized by episodic, progressive inflammatory destruction of cartilage. 27 The exact etiology and physiopathology of the disease has not been established. 28 It affects cartilaginous structures including ears, nose, tracheobronchial tree, and joints; it can also involve noncartilaginous tissues rich in proteoglycans such as the eyes, inner ear, heart, blood vessels, and kidney.…”

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“…28 It affects cartilaginous structures including ears, nose, tracheobronchial tree, and joints; it can also involve noncartilaginous tissues rich in proteoglycans such as the eyes, inner ear, heart, blood vessels, and kidney. 27,28 Diagnostic criteria were established by Michet et al 29 which require the presence of proven inflammation in at least two of three of the auricular, nasal, or laryngotracheal cartilages, or proven inflammation in one of these cartilages plus two other signs, including ocular inflammation, vestibular dysfunction, seronegative inflammatory arthritis, or hearing loss. 28,29 Our case is consistent with the diagnosis of TINU syndrome and was confirmed histopathologically with renal biopsy associated with typical bilateral uveitis.…”

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Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature

Aguilar¹,

Lonngi²,

de-la-Torre

2015

Ocular Immunology and Inflammation

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Purpose:To review the literature on tubulointerstitial nephritis and uveitis (TINU) syndrome, and to report a case of a patient with relapsing polychondritis (RP) and TINU syndrome. Method: TINU syndrome is a rare oculo-renal inflammatory disorder. It is more common in young women with autoimmune conditions, infections, systemic disease, and previous use of medications. We report the case of a 62-year-old woman with relapsing polychondritis and a 2-year history of acute, recurrent, asymmetric, bilateral, anterior, nongranulomatous uveitis accompanied by tubulointerstital nephritis. The patient was diagnosed with TINU syndrome associated with relapsing polychondritis. No cases of this association have been reported in the literature. The clinical features of TINU syndrome are discussed based on the published works. Conclusion: TINU is an uncommon syndrome; only about 200 cases have been reported in the literature related to infections, systemic disease, and previous use of medications such as antibiotics and non-steroidal anti-inflammatory drugs. We found that it can be associated with relapsing polychondritis; therefore, it is important to investigate symptoms of this disease since TINU syndrome can co-exist with it.

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confidence: 99%

Tubulointerstitial Nephritis and Uveitis Syndrome: Case Report and Review of the Literature

Aguilar¹,

Lonngi²,

de-la-Torre

2015

Ocular Immunology and Inflammation

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“…Clinical features include unilateral or bilateral painful erythematous swelling of the affected cartilage; the earlobe is typically not affected [ 2 ] . Apart from bilateral auricular chondritis, the condition may be associated with ophthalmitis and audiovestibular lesions [ 3 ] ; neither was present in our patient. As in the case of our patient, histology of relapsing polychondritis is characterized by a mixed perichondral infi ltrate predominantly made up of lymphocytes and plasma cells [ 1,3 ] .…”

Section: Discussionmentioning

confidence: 44%

Recurrent swelling of the ear

Chylla

Hein

Biedermann

et al. 2017

J Deutsche Derma Gesell

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A 55-year-old patient who worked as the operations manager at an aerial cable car facility presented with a one-year history of recurrent painful infl ammation of both auricles. Each episode had lasted several weeks and had clinically been characterized by erythematous swelling of the affected ear with mild scaling as well as a fetid discharge. The patient had not been free of symptoms since the initial onset of lesions. Topical measures initiated by an ENT specialist, who had suspected otitis externa associated with chronic dermatitis of the auditory canal, had not resulted in any lasting improvement. At the same time, the patient had also noticed weight loss, night sweats, fatigue, as well as progressive yet mild hearing loss and infl ammation of both eyes, which had prompted him to present to a rheumatologist. A comprehensive rheumatological workup had revealed no pathological fi ndings, apart from elevated ANA levels, which had been interpreted as a nonspecifi c epiphenomenon. Clinical findings and histologyThe right ear was markedly swollen, tender to pressure, warm, and had an erythematous/violaceous hue; there was mild fi ne-lamellar scaling at the external auditory meatus. On the glabella and along the eyelashes on both sides, there was an ill-defi ned, slightly scaling erythema (Figure 1 a, b). Right submandibular lymphadenopathy was noted. The patient was afebrile. A biopsy was taken from the anthelix of the affected ear (Figure 2 a, b). Laboratory testsA complete blood count with differential, C-reactive protein, and liver and kidney function tests were within normal limits. Serum protein electrophoresis was unremarkable, the ANA titer (1 : 320) was elevated. Fungal and bacterial swabs taken from the affected ear and auditory canal were without pathological fi ndings.

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“…Aseptic meningitis, with thickening of the meninges, lymphocytic meningoencephalitis, rhomboencephalitis and cerebral aneurysms can also occur. 1,[10][11][12] In our case we made the diagnosis solely on clinical grounds, as there was evidence on physical examination of chondritis of both ear lobes, sero-negative polychondritis and neurological compromise with aseptic meningitis. About 25% of patients die in up to five years following diagnosis; laryngotracheal involvement and cardiovascular complications are the leading causes …”

Section: Discussionmentioning

confidence: 97%