Relation between indices of end-organ damage and mean platelet volume in hypertensive patients

Bulur, Serkan; Önder, Halil; Aslantaş, Yusuf; Ekinözü, İ̇smail; Kilic, A.; Yalçin, Sübhan; Bulur, Şule; Özhan, Hakan

doi:10.1097/mbc.0b013e32835291b1

Cited by 21 publications

(15 citation statements)

References 11 publications

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“…In a recent study with hypertensives, a positive correlation with the degree of hypertensive retinopathy was shown (50). Some authors did not find any correlation with MPV and blood pressure levels (12), and also with hypertensive retinopathy (51). We think that this discordance may be explained by the treatment of our and their hypertensive patients.…”

Section: Discussionmentioning

confidence: 62%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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IntroductionDiabetes mellitus (DM), a major global health problem, is commonly associated with increased risk of developing micro-and macrovascular disease. Despite its clinical importance, the pathophysiology of diabetic complications is not completely understood. Platelets have been thought to be involved in these complications. Diabetic retinopathy (DR) is one of those important complications and leads to a considerable increase in morbidity.Platelet volume is a marker of platelet activation and function that can be measured easily as mean platelet volume (MPV) by clinical analyzers. It is now known that larger platelets are more reactive and produce more prothrombotic factors (1,2). Increased MPV has been demonstrated in diabetes (3-9). There are conflicting results about the relation of MPV with diabetic nephropathy/microalbuminuria (MA) (10-17), diabetic neuropathy (18-20), coronary artery disease (4,13,18,(21)(22)(23)(24)(25), and cerebrovascular disease (3-5,26) in diabetic patients. Large platelets may play a role in the development of vascular damage in DR by being more active, forcing the production of more prothrombotic factors, or causing endothelium-dependent vasomotor dysfunction.Keeping in mind these complex relations between MPV, diabetes, and its complications, in the present study we aimed to: 1) compare the MPV in diabetic patients with that in healthy controls; 2) determine if there is a difference in MPV between diabetic patients with and without DR, and also with and without proliferative retinopathy; 3) compare MPV levels of diabetic patients with or without hypertension (HTA), hyperlipemia (HL), and HTA with HL, and 4) see if there is a correlation of MPV with HbA1c and body mass index (BMI) in diabetic patients. Material and methods PatientsA total of 102 type 2 DM (T2DM) patients [65 female (63.7%), 35 male (36.3%)], 50 of them without retinopathy [31 female (62.0%), 19 male (38.0%)] and 52 with retinopathy [34 female (65.4%), 18 male (34.6%)], aged 22-90 years, were recruited from the Clinic of Ankara Education and Research Hospital from June 2009 to June Background/aim: Patients with diabetes mellitus have an increased risk of developing micro-and macrovascular complications. Retinopathy is one of the most important complications of diabetes whose pathophysiological cause has not yet been determined. One candidate may be platelet volume. In this study we aimed to investigate the association between mean platelet volume and diabetic retinopathy.Materials and methods: Mean platelet volume levels were investigated in type 2 diabetic patients with and without retinopathy, and in healthy participants. After reclassifying our diabetics in terms of the presence or absence of hypertension and hyperlipidemia, we compared their mean platelet volumes. We then checked to see if the mean platelet volume correlated with hemoglobin A1c and body mass index. Results:The mean platelet volume levels were higher in all diabetic patients, and they were highest in diabetics with retinopathy. The mean plate...

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Section: Discussionmentioning

confidence: 62%

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Güngör¹,

Gürsoy

Güngör³

et al. 2016

Turk J Med Sci

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“…Other studies have shown an association between hypertension and MPV. 4,[13][14][15] However, the relationship between LVMI and MVP is unclear. MPV was found to be significantly higher in patients with hypertension than in normotensive control subjects, and within the hypertensive group larger platelets were associated with target-organ damage.…”

Section: Discussionmentioning

confidence: 99%

Relationship between mean platelet volume elevation and left ventricular mass index in hypertensive patients

et al. 2014

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Objectives: To compare the mean platelet volume (MPV; a general marker of platelet activation) in groups of patients with and without hypertension and to analyse its relationship with left ventricular mass index (LVMI). Methods: This cross-sectional, observational study enrolled newly diagnosed patients with untreated stage I-II hypertension and healthy control subjects without hypertension. MPV was measured using a haematology analyser. Echocardiography was performed on all of the study participants. Results: A total of 50 newly diagnosed patients with hypertension and 50 healthy control subjects were enrolled in the study. The majority of the demographic characteristics and laboratory findings were not significantly different between the two groups. The mean AE SD MPV was significantly higher in the hypertensive group compared with the control group (10.3 AE 1.4 fl versus 9.2 AE 1.8 fl, respectively). The mean AE SD LVMI was significantly higher in the hypertensive group compared with the control group (115.9 AE 23.0 g/m 2 versus 95.7 AE 23.4 g/m 2 , respectively). There was no significant correlation between MPV and LVMI. Conclusion: In patients with untreated hypertension, despite elevated MPV levels there was no correlation between LVMI and MPV.

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“…Results from studies evaluating MPV in patients with peripheral artery disease, unprovoked deep vein thrombosis and pulmonary embolism further advocate a potential role for MPV in identifying patients at high risk of thrombosis [16,17]. In various studies MPV value was found higher in patient with autoinflammatory disease such as psoriasis, romatoid arthritis, ankylosing spondylitis, and Behcet's disease than controls [18,19]. For example, Yazıcı et al [20,21] found that MPV was significantly higher in patients with rheumatoid arthritis and with ankylosing spondyloarthritis and MPV can reflect both disease activity and decrease in response to anti-inflammatory therapy.…”

Section: Discussionmentioning

confidence: 90%

Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid

et al. 2013

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Relation between indices of end-organ damage and mean platelet volume in hypertensive patients

Cited by 21 publications

References 11 publications

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

The relationship of mean platelet volume with retinopathy in type 2 diabetes mellitus

Relationship between mean platelet volume elevation and left ventricular mass index in hypertensive patients

Mean platelet volume and eosinophilia relationship in patients with bullous pemphigoid

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