Relationship between mean platelet volume elevation and left ventricular mass index in hypertensive patients

Abstract

Objectives: To compare the mean platelet volume (MPV; a general marker of platelet activation) in groups of patients with and without hypertension and to analyse its relationship with left ventricular mass index (LVMI). Methods: This cross-sectional, observational study enrolled newly diagnosed patients with untreated stage I-II hypertension and healthy control subjects without hypertension. MPV was measured using a haematology analyser. Echocardiography was performed on all of the study participants. Results: A total of 50 newly diagnosed patients with hypertension and 50 healthy control subjects were enrolled in the study. The majority of the demographic characteristics and laboratory findings were not significantly different between the two groups. The mean AE SD MPV was significantly higher in the hypertensive group compared with the control group (10.3 AE 1.4 fl versus 9.2 AE 1.8 fl, respectively). The mean AE SD LVMI was significantly higher in the hypertensive group compared with the control group (115.9 AE 23.0 g/m 2 versus 95.7 AE 23.4 g/m 2 , respectively). There was no significant correlation between MPV and LVMI. Conclusion: In patients with untreated hypertension, despite elevated MPV levels there was no correlation between LVMI and MPV.

Study of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Hypertensives and Normotensives

“…Mean platelet volume has been shown to be a marker of platelet activation, which plays important role in pathophysiology of atherosclerosis. [14] Present study shows significantly higher NLR in hypertensives (Table 4) which is in accordance with the following studies. Park B et al found that higher NLR was independently associated with arterial stiffness and they concluded that high NLR is an additional measure in assessing cardiovascular risk in clinical practice.…”

The Predictive Role of Hematological Parameters in Hypertension

“…In contrast, Bulur et al 82 and Yavuzkir et al 83 failed to find a correlation between MPV and subclinical end-organ damage in hypertensive patients. We think the causes of these differences could be the different populations and other unevenly distributed confounding factors.…”

“…86 Yarlioglues et al 80 and Gokdemir et al 81 pointed out in the literature that EDTA was used in blood samples for anticoagulation and MPV was measured within 1 hour. In Yavuzkir et al's 83 study, blood samples containing EDTA were left at room temperature for 3 hours before MPV was measured. Bulur et al 82 did not mention which type of anticoagulant was used in the blood samples and the time interval between blood sample collection and MPV measurement in their study.…”

The Relationship Between Heart Rate Recovery and Mean Platelet Volume in Healthy Individuals

“…Elevated MPV is related to increased aggregation, thromboxane synthesis, β-thromboglobulin release, and adhesion molecule expression (9). Higher MPV levels were detected in patients with hypertension, hypercholesterolemia, diabetes mellitus, smoking, and metabolic syndrome (10)(11)(12)(13)(14).…”