Relation of distal tubular NaCl delivery and glomerular hydrostatic pressure

Blantz, Roland C.; Israelit, Arnold H.; Rector, Floyd C.; Seldin, Donald W.; Green, John M.

doi:10.1038/ki.1972.66

Cited by 76 publications

(45 citation statements)

References 17 publications

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“…The specific modifications to the equations describing these relationships have been described in previous publications from this laboratory (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Surgical preparation for micropuncture was as previously described in recent studies from this laboratory (11)(12)(13)(14)(15). All micropuncture studies were paired.…”

Section: Introductionmentioning

confidence: 99%

“…The maintaining infusion was discontinued during AGBM Ab injection to prevent acute volume expansion. 15 to perform clearances before and after AGBM Ab infusion in the same rat to examine the possibility of inulin sieving across the glomerulus.…”

Section: Introductionmentioning

confidence: 99%

“…Total filtration rates, renal plasma flow, and renal blood flow were calculated as previously described (11)(12)(13)(14)17 Calcutlationts. The calculation of superficial nephron filtration fraction (snff), nephron plasma flow (rpf), nephron blood flow (rbf), afferent arteriolar resistance (AR), and efferent arteriolar resistance (ER) was as described in previous publications from this laboratory (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Methods for pressure measurement and the mechanics of the pressure monitoring device were as described previously from this laboratory (11,15). At least three samples of efferent peritubular blood were obtained from "star" vessels on the kidney surface (11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

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Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Blantz¹,

Wilson²

1976

J. Clin. Invest.

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A B S T R A C T Nephron filtration rate (sngfr) and the factors controlling filtration were examined before and within 60 min of the intravenous infusion of 225-450 Ag of antiglomerular basement membrane antibody (AGBM Ab) (> 50% antigenic saturation) in plasma-expanded (2.5% body wt) Munich-Wistar rats. Pressures in glonmerular capillaries (PG) and Bowman's space (Pt) were measured with a servo-nulling device, systemic (l7rA) and efferent arteriolar oncotic pressures (irE) were measured by microprotein methods, and nephron plasma flow (rpf) and sngfr were measured by micropuncture techniques in both control and post-AGBM Ab conditions in each rat. The sngfr fell from 52.7±2.9 to 24.1±+1.9 nl/min per g kidney wt (n = 7, P <0.001).Both afferent and efferent arteriolar resistances increased and rpf fell from 221±25 to 90±9 nl/min per g kidney wt (P < 0.001) but the hydrostatic pressure gradient across the glomerular membrane (AP = PG -Pt) increased from 37±1 to 50±2 mm Hg (P < 0.001). The increase in AP and a numerical decrease in TA both acted to maintain sngfr after AGBM Ab and effectively nullified the influence of decreased rpf upon sngfr. The nmean effective filtration pressure (EFP = AP -i) increased from 14±2 to 30±3 mm Hg (P < 0.001) while sngfr decreased. The major and critical reason for this reduction in sngfr was a decrease in the glomerular permeability coefficient from 0.077+0.017 to 0.014+0.001 nl/s per g kidney wt per mm Hg (P <0

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“…The specific modifications to the equations describing these relationships have been described in previous publications from this laboratory (11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

“…Surgical preparation for micropuncture was as previously described in recent studies from this laboratory (11)(12)(13)(14)(15). All micropuncture studies were paired.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Blantz¹,

Wilson²

1976

J. Clin. Invest.

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Renal Circulation

Knox

Spielman

1983

Comprehensive Physiology

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Renal Micropuncture Techniques

Velázquez

Wright

1992

Comprehensive Physiology

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The sections in this article are: Animal Subjects Equipment, Tools Dissecting Microscopes Compound Microscopes Pipette Pullers and Grinders Capillary Glass, Micropipettes Syringes, Tubing Micromanipulators Microperfusion Pumps Infusion Pumps Heated Micropuncture Tables Pressure Transducers Specialized Surgical Equipment Scintillation Counters Voltmeters Electrodes Recorders Oil and Wax Blocks Wax Injection Apparatus Timers In Vivo Micropuncture: Functional Assessment of Individual Nephron Segments Anesthesia and Surgery Evaluation of Kidney before Micropuncture Micropipette Placement Identification of Accessible Cortical Tubules and Vessels Identification of Papillary Structures Measurement of Distance to Puncture Site and Length of Perfused Tubule Determination of Filtration and Transport Rates Determination of Blood Constituents Measurement of Capillary and Tubule Pressure Potential Problems Micropuncture in Nonstandard Preparations Microanalytical Techniques Volume Inulin Protein Urea Osmolality Metal Cations Halide Anions Ammonia Carbon Dioxide and Bicarbonate

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Relation of distal tubular NaCl delivery and glomerular hydrostatic pressure

Cited by 76 publications

References 17 publications

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Acute effects of antiglomerular basement membrane antibody on the process of glomerular filtration in the rat.

Renal Circulation

Renal Micropuncture Techniques

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