Relation of Nicotinic Acid and Nicotinic Acid Amide to Canine Black Tongue

Poverty Results In Madness: A Testimony from the Past

“…However, this was afterwards; in the twentieth century the deficiency factor was identified in niacin or PPPellagra Prevention-vitamin [23,24].…”

Comparative nutrition and metabolism: Explication of open questions with emphasis on protein and amino acids

“…Golberger in 1922 (46) is generally given credit for discovering a cure for black tongue in dogs and pellagra in humans (47), but it was not until 1937 that Elvehjem et al (48) isolated nicotinamide from liver extracts and showed that this compound would cure black tongue in dogs. Seventy years earlier, German chemists had actually synthesized nicotinic acid, but because this compound did not cure beri-beri in humans (now known to be caused by thiamin deficiency), it remained an unappreciated chemical entity for several decades (1).…”

Personal Reflections on Clinical Investigations

“…In 1937, Elvehjem, Woolley, and their associates (27) found that canine black tongue, which Goldberger had identifi ed as a good experimental model of human pellagra, was relieved dramatically by nicotinic acid. It was most interesting to see the spectacular and sometimes astonishing efforts to establish priority of publication in nailing nicotinic acid to the clinical mast.…”