Relation of serum reverse T3 to amiodarone antiarrhythmic efficacy and toxicity

Kerin, Nicholas Z.; Blevins, Roger D.; Benaderet, David; Faitel, Kathyl; Jarandilla, Regina; Garfinkel, Chaim; Klein, S.; Rubenfire, Melvyn

doi:10.1016/0002-9149(86)90965-3

Cited by 19 publications

(2 citation statements)

References 15 publications

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“…The elevated ESR is of particular interest, although not pathognomic, it woul not be expected in congestive heart failure or pulmonary embolism, the major differential diagnostic considerations in this setting. Serum levels of reverse T 3 , an inactive metabolite of T 4 , have also been proposed as a useful test to predict APT as well as its antidysrhythmic effect 11 ) .…”

Section: Discussionmentioning

confidence: 99%

A Case of Amiodarone-Associated Pulmonary Toxicity

Kwon

Jeong

et al. 1995

Korean J Intern Med

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Amiodarone is an iodinated benzofuran derivative that represents a new and extremely effective therapy for certain life-threatening refractory cardiac arrgythmia. There are numerous side effects associated with amiodarone therapy, including corneal microdeposits. Skin reactions and others. Pulmonary toxicity, however, represents the most serious adverse reaction limiting the clinical efficacy of this antidysrhythmic drug, Recently, we experienced a case of amiodarone-induced pulmonary toxicity confirmed by open lung biopsy with light-and electron-microscopy. So, we report a case of amiodarone-induced pulmonary toxicity with a literature review.

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Section: Discussionmentioning

confidence: 99%

A Case of Amiodarone-Associated Pulmonary Toxicity

Kwon

Jeong

et al. 1995

Korean J Intern Med

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“…16,17 More than 50% of patients treated with amiodarone have nonclinical abnormalities of thyroid function manifested by a slightly elevated serum free thyroxine (T4) level, normal or low triiodothyronine (T3) levels, elevated reverse T3 level, or transiently increased or decreased thyroid-stimulating hormone (TSH) concentration. 18,19 Most of the patients with T4, T3, reverse T3, or TSH abnormalities remain clinically euthyroid. In patients with suspected amiodarone-induced thyrotoxicosis, the degree of TSH, T3, and T4 abnormalities together with clinical signs should confirm its presence.…”

Section: Introductionmentioning

confidence: 99%

Atrial Fibrillation: Focus on New Therapeutic Strategies

Kerin

Lieberman²

2004

American Journal of Therapeutics

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Serum reverse T₃ and amiodarone efficacy

Haberman

Ladenson

Griffith

et al. 1989

Clinical Cardiology

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Summary:The use of serum reverse T, (rT,) levels in the assessment of amiodarone efficacy is controversial. We prospectively studied 10 patients with frequent ventricular ectopy and symptomatic ventricular tachycardia (VT) treated with amiodarone. Serial 24-h Holter monitor, thyroid function studies including serum rT,, and 12-lead electrocardiogram were performed on each patient at baseline, and at 1,4, 12, and 24 weeks of oral amiodarone therapy. Serial Holter monitors on therapy were analyzed for 100% suppression of VT, 90% suppression of couplets, and 85 % suppression of ventricular ectopic beats (VEBs) compared with baseline Holter, defining patient groups VT-, Co-, and VEB-, respectively. Lack of arrhythmia suppression to this degree defined groups as VT + , Co + , and VEB + . There were no statistically significant differences in rT, levels between VT + and VTgroups, Co + and Co -groups, or the VEB + and VEBgroups. VT suppression could not be predicted at any rT, level. We conclude that serum rT, is an insensitive means of assessing amiodarone efficacy.

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Relation of serum reverse T3 to amiodarone antiarrhythmic efficacy and toxicity

Cited by 19 publications

References 15 publications

A Case of Amiodarone-Associated Pulmonary Toxicity

A Case of Amiodarone-Associated Pulmonary Toxicity

Atrial Fibrillation: Focus on New Therapeutic Strategies

Serum reverse T₃ and amiodarone efficacy

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Relation of serum reverse T3 to amiodarone antiarrhythmic efficacy and toxicity

Cited by 19 publications

References 15 publications

A Case of Amiodarone-Associated Pulmonary Toxicity

A Case of Amiodarone-Associated Pulmonary Toxicity

Atrial Fibrillation: Focus on New Therapeutic Strategies

Serum reverse T3 and amiodarone efficacy

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Serum reverse T₃ and amiodarone efficacy