Relationship between advanced glycation end‐product accumulation and low skeletal muscle mass in Japanese men and women

Kato, Michitaka; Kubo, Akira; Sugioka, Yosuke; Mitsui, Rie; Fukuhara, Nobuki; Nihei, Fumi; Takeda, Yoshihiko

doi:10.1111/ggi.12787

Cited by 38 publications

(51 citation statements)

References 33 publications

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“…Prior studies have shown that TUG is a good screening tool for sarcopenia among hospitalized older patients and home‐dwelling older adults . Furthermore, AGE is an independent factor of low SMI among middle‐aged and older adults . An experimental study found that mice with high AGE diet showed CML accumulation in their extensor digitorum longus muscle and low muscle strength .…”

Section: Discussionmentioning

confidence: 99%

“…The highest quartile of skin AGE levels was correlated with low skeletal muscle mass in older adults . In the studies of participants' skin, AGE was significantly associated with low SMI, incidence of frailty, and low levels of physical activity and functioning . Notably, CML is one type of non‐fluorescent AGE.…”

Section: Discussionmentioning

confidence: 99%

“…18,19 Furthermore, AGE is an independent factor of low SMI among middle-aged and older adults. 20 An experimental study found that mice with high AGE diet showed CML accumulation in their extensor digitorum longus muscle and low muscle strength. 21 Another in vitro study showed that AGEs can inhibit the myogenesis of C 2 C 12 cells.…”

Section: Discussionmentioning

confidence: 99%

“…23 In the studies of participants' skin, AGE was significantly associated with low SMI, incidence of frailty, and low levels of physical activity and functioning. 20,25,26 Notably, CML is one type of nonfluorescent AGE. The use of skin autofluorescence cannot detect CML levels or estimate the effect of CML.…”

Section: Discussionmentioning

confidence: 99%

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Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

Yang

Liu

et al. 2019

Geriatrics Gerontology Int

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Aim Advanced glycation end‐products are important factors in muscle function and physical performance among older adults. However, the association between sarcopenia and urinary carboxymethyl‐lysine (uCML) levels remains unclear. The present study aimed to investigate the relationship among uCML levels, skeletal muscle mass, physical performance and sarcopenia among community‐dwelling older adults. Methods This work was a community‐based cross‐sectional study. The participants were recruited from the Taichung Community Health Study‐Elderly and were followed up until 2017. A total of 104 participants underwent dual‐energy X‐ray absorptiometry examination, physical performance tests and measurement of uCML levels. After the natural log transformation of the uCML levels, Pearson's correlation coefficient and a general linear model were used for statistical analysis. Results The mean uCML levels of older men and women were 1.34 μg/mg and 1.63 μg/mg creatinine, respectively. After multivariate adjustment, grip strength among older women significantly decreased as uCML levels increased. Participants with uCML levels and Timed Up and Go test values higher than the median had a 13.76‐fold risk of acquiring sarcopenia compared with those whose corresponding variables were lower than the median after adjusting for age, sex, body fat percentage, and serum creatinine and blood urea nitrogen levels. Conclusions uCML levels were negatively associated with grip strength among older women. The joint association of uCML and Timed Up and Go test values was correlated with the risk of acquiring sarcopenia among older adults. This finding suggests that uCML levels can be used as a biomarker for screening sarcopenia and as a strategy for treating sarcopenia. Geriatr Gerontol Int 2019; 19: 1017–1022.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

Yang

Liu

et al. 2019

Geriatrics Gerontology Int

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“…SAF levels were measured with an AGE Reader (Diag-nOptics Technologies B.V., Groningen, Netherlands) [17]. This noninvasively evaluates the accumulation of AGEs in the skin by measuring the level of fluorescence with light excitation [18].…”

Section: Skin Autofluorescencementioning

confidence: 99%

Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Kunimoto

Shimada

Yokoyama

et al. 2020

BMC Cardiovasc Disord

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Background: Advanced glycation end products (AGEs) are associated with aging, diabetes mellitus (DM), and other chronic diseases. Recently, the accumulation of AGEs can be evaluated by skin autofluorescence (SAF). However, the relationship between SAF levels and exercise capacity in patients with cardiovascular disease (CVD) remains unclear. This study aimed to investigate the association between the tissue accumulation of AGEs and clinical characteristics, including exercise capacity, in patients with CVD. Methods: We enrolled 319 consecutive CVD patients aged ≥40 years who underwent early phase II cardiac rehabilitation (CR) at our university hospital between November 2015 and September 2017. Patient background, clinical data, and the accumulation of AGEs assessed by SAF were recorded at the beginning of CR. Characteristics were compared between two patient groups divided according to the median SAF level (High SAF and Low SAF). Results: The High SAF group was significantly older and exhibited a higher prevalence of DM than the Low SAF group. The sex ratio did not differ between the two groups. AGE levels showed significant negative correlations with peak oxygen uptake and ventilator efficiency (both P < 0.0001). Exercise capacity was significantly lower in the high SAF group than in the low SAF group, regardless of the presence or absence of DM (P < 0.05). A multivariate logistic regression analysis showed that SAF level was an independent factor associated with reduced exercise capacity (odds ratio 2.10; 95% confidence interval 1.13-4.05; P = 0.02). Conclusion: High levels of tissue accumulated AGEs, as assessed by SAF, were significantly and independently associated with reduced exercise capacity. These data suggest that measuring the tissue accumulation of AGEs may be useful in patients who have undergone CR, irrespective of whether they have DM.

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Post‐translational regulation of muscle growth, muscle aging and sarcopenia

Zhong

Zheng

et al. 2023

J cachexia sarcopenia muscle

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Skeletal muscle makes up 30-40% of the total body mass. It is of great significance in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising, protecting joints and many other aspects. Moreover, muscle is also an important metabolic organ that helps to maintain the balance of sugar and fat. Defective skeletal muscle function not only limits the daily activities of the elderly but also increases the risk of disability, hospitalization and death, placing a huge burden on society and the healthcare system. Sarcopenia is a progressive decline in muscle mass, muscle strength and muscle function with age caused by environmental and genetic factors, such as the abnormal regulation of protein post-translational modifications (PTMs).

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Relationship between advanced glycation end‐product accumulation and low skeletal muscle mass in Japanese men and women

Abstract: Skin autofluorescence was an independent factor associated with low skeletal muscle index among middle-aged and older Japanese men and women. Geriatr Gerontol Int 2017; 17: 785-790.

Cited by 38 publications

References 33 publications

Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

Relationship among urinary advanced glycation‐end products, skeletal muscle mass and physical performance in community‐dwelling older adults

Association between the tissue accumulation of advanced glycation end products and exercise capacity in cardiac rehabilitation patients

Post‐translational regulation of muscle growth, muscle aging and sarcopenia

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