Relationship between branched-chain amino acid to tyrosine ratio (BTR) and porto-systemic shunt in the Child-Pugh grade A cirrhosis determined by per-rectal portal scintigraphy

Habu, Daiki; Nishiguchi, Shuhei; Nakatani, Shinji; Kawamura, Etsushi; Ishizu, Hirotaka; Lee, Chulyoo; Ohfuji, Satoko; Fukushima, Wakaba; Tanaka, Takashi; Kawamura, T; Shiomi, Susumu

doi:10.1016/s1386-6346(03)00191-8

Cited by 8 publications

(6 citation statements)

References 7 publications

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“…Habu et al studied the correlation between branched amino-acids and portosystemic shunt [20] . But we are the first group comparing this test with Child's criteria.…”

Section: Discussionmentioning

confidence: 99%

Determination of Portal Shunt Index Using 123-Iodoamphetamine Transrectally

Maimani¹,

Khazindar²,

Alharbi³

2005

med

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Liver cirrhosis with portal hypertension is one of the leading causes of death in Saudi Arabia. There are different modalities of investigation and treatment, the method which denotes the best way of treatment, is not yet discovered. 123-Iodoamphetamine was injected through the rectum in 17 patients. Sequential images of the chest and upper abdomen were obtained for 1 hour. Shunt index was calculated. There was a high correlation between Child's classification and shunt index. For Class C, all have shunting index of 100%. We found that 123-Iodoamphetamine method is a simple and non-invasive method in the assessment of patients with liver cirrhosis.

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“…Habu et al studied the correlation between branched amino-acids and portosystemic shunt [20] . But we are the first group comparing this test with Child's criteria.…”

Section: Discussionmentioning

confidence: 99%

Determination of Portal Shunt Index Using 123-Iodoamphetamine Transrectally

Maimani¹,

Khazindar²,

Alharbi³

2005

med

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“…It has been reported that after liver transplantation, AAA levels rapidly return to a normal as liver function recovers [12]. We have previously mentioned that portosystemic shunt causes AAAs to "pass through" the liver, and that this may play a role in the mechanism of the increase in AAA levels [13].…”

Section: Present Situation Of Supplementation With Bcaasmentioning

confidence: 97%

Effect of oral supplementation with branched-chain amino acid granules in the early stage of cirrhosis

Nishiguchi

Habu

2004

Hepatology Research

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“…classified their patients into four treatment arms based on their serum albumin level and the BTR . The decrease in the serum albumin level was inhibited after therapy using BCAA granules even in patients with a serum albumin level of 3.6 g/dL or more if their BTR was 4 or less, so the authors highlighted the usefulness of early intervention with BCAA granules . A prospective, multicenter study in Japanese patients with hepatitis C virus‐related decompensated cirrhosis with a serum albumin level of 3.6 g/dL or more complicated with insulin resistance (BCAA Granules for patients with Hepatitis C virus‐related Liver Cirrhosis and Insulin Resistance on the Effect of Reduction of Carcinogenic Risk in the Liver [BLOCK] study, Japan Liver Oncology Group [JLOG] 1004 Trial) is ongoing.…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of therapy using branched‐chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma

Nishikawa

Osaki

2013

Hepatology Research

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The liver is the major organ for the metabolism of protein, fat and carbohydrate. A nutritional approach is required in the treatment of cirrhosis, which is frequently complicated with protein-energy malnutrition. Several advanced treatment approaches for hepatocellular carcinoma (HCC) have been established in the past decade. HCC is often complicated by cirrhosis, so treatment of the underlying liver diseases is also necessary to improve the prognosis. Branched-chain amino acid (BCAA) granules were developed originally for the treatment of hypoalbuminemia associated with decompensated cirrhosis. However, subsequent studies found various other pharmacological actions of this agent. We review the clinical significance of therapy using BCAA granules in patients receiving different treatment approaches for cirrhosis and HCC based on the published work as well as our own data.

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Relationship between branched-chain amino acid to tyrosine ratio (BTR) and porto-systemic shunt in the Child-Pugh grade A cirrhosis determined by per-rectal portal scintigraphy

Cited by 8 publications

References 7 publications

Determination of Portal Shunt Index Using 123-Iodoamphetamine Transrectally

Determination of Portal Shunt Index Using 123-Iodoamphetamine Transrectally

Effect of oral supplementation with branched-chain amino acid granules in the early stage of cirrhosis

Clinical significance of therapy using branched‐chain amino acid granules in patients with liver cirrhosis and hepatocellular carcinoma

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