Relationship between breath-hold time and physical performance in patients with cystic fibrosis

Abstract

Rehabilitation including physiotherapy is an important part of the treatment used to help improve the quality of life of patients with cystic fibrosis (CF). The aim of this study was to determine the value of the breath-hold time as an index of exercise tolerance in patients with CF. Eighteen patients in different states of CF were included. The breath-hold time was measured in all patients. The fitness level was assessed by means of a progressive exercise test on a cycle-ergometer. During the test, oxygen uptake (VO(2)) and carbon dioxide elimination (VCO(2)) were measured breath by breath. The VO(2) and working capacity (WC) were computed at the anaerobic threshold (AT) and at peak. Duration of breath-hold was 24.7 +/- 2.87 (mean +/- SEM) seconds, varying between 10 and 58. The breath-hold time (BHT) displayed a significant correlation with VO(2) (r = 0.898), WC (r = 0.899) at the AT, and the peak VO(2) (r = 0.895). Regression equations were: VO(2) at the AT (ml/kg) = 5.53 + 0.42 x BHT and WC at the AT (watt/kg) = 0.56 + 0.38 x BHT Our results suggest that the voluntary breath-hold time might be a useful index for prediction of the exercise tolerance of CF patients.

Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children

“…Most forms of Cystic Fibrosis (CF) induce an impairment of the ventilatory function, characterized by an obstructive syndrome induced by mucus retention and inflammation of the airways . Thus, several changes of breathing pattern at rest and during exercise characterized by a more rapid and shallow breathing and an increased ventilatory response have been highlighted both in adults and in children with cystic fibrosisin comparison with healthy population …”

Maximal Voluntary Breath-Holding Tele-Inspiratory Test in Patients with Chronic Obstructive Pulmonary Disease

“…Normal BMI values were between 20 and 24.9 Kg/m². Obesity was defined by a BMI ≥ 30 Kg/m² ( Barnai et al, 2005 ).…”

“…It has been reported that this test is an interesting tool to detect asthmatic subjects with a poor perception of dyspnea, which is a risk factor for fatal asthma ( Nannini et al, 2007 ). In adult subjects with cystic fibrosis, MVIBHT is correlated with oxygen consumption at the anaerobic threshold, providing information about the exercise capacity of these subjects ( Barnai et al, 2005 ).…”

Effets des entraînements aérobies et anaérobies chez les patients atteints de mucoviscidose

“…La kinésithérapie est le plus souvent utilisée au niveau respiratoire, afin de drainer le mucus et désencombrer les patients. La qualité de vie chez les patients atteints de mucoviscidose repose principalement sur la condition physique et la fonction pulmonaire [1]. L'inactivité physique peut aggraver la maladie.…”

“…Pour calculer la consommation d'oxygène à partir du seuil anaéro-bique la formule est : 5,53 + 0,42 Â BHT et pour calculer la capacité d'exercice à partir du seuil anaérobique, la formule est : 0,56 + 0,38 Â BHT. Cette méthode est non invasive contrairement aux traditionnels tests d'effort[1], ce qui pré-sente un avantage. L'article de Gruber et al de 2011 s'intéresse à l'état de forme initial des patients à travers leur consommation d'oxygène (V'O 2 ).…”