Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy

Takamatsu, Yuki; Higashide, Tomomi; Takeshima, Satoshi; Sasaki, Makoto; Manbo, Yoshimi; Udagawa, Sachiko; Ohkubo, Shinji; Sonoda, Shozo; Sakamoto, Taiji; Sugiyama, Kazuhisa

doi:10.1167/tvst.10.14.30

Cited by 5 publications

(9 citation statements)

References 30 publications

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“…Moreover, changes in the circulatory parameters (i.e., MAP or OPP), but not IOP changes, were significant factors associated with MT changes in βPPA. Takamatsu et al reported that MBR changes in the macula after trabeculectomy correlated significantly with changes in MAP or OPP, but not IOP changes 22 . The common feature between βPPA and the macula (i.e., MBR changes associated with changes in circulatory parameters) also supports the significance of choroidal blood flow in βPPA.…”

Section: Discussionmentioning

confidence: 99%

“…In this prospective study, the blood flow in the temporal ONH and PPA regions was measured using LSFG before and after trabeculectomy. Many previous studies have reported postoperative changes in blood flow in the ONH 11 – 22 , but no study has investigated such changes by focusing on the PPA regions. Witkowska et al reported exercise-induced changes in peripapillary blood flow using LSFG.…”

Section: Discussionmentioning

confidence: 99%

“…The unique structural characteristics of βPPA from ONH and γPPA are the location outside BMO and the presence of the choroid. Since the macular choroidal blood flow increased after trabeculectomy 11 , 22 , MT increase in βPPA may reflect blood flow changes in the peripapillary choroid. Moreover, changes in the circulatory parameters (i.e., MAP or OPP), but not IOP changes, were significant factors associated with MT changes in βPPA.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Several studies have reported changes in the blood flow in the fundus after trabeculectomy 11 – 22 . Takamatsu et al showed that blood flow in the macula, measured using laser speckle flowgraphy (LSFG), significantly increased after trabeculectomy 22 . Tamaki et al and Takeshima et al reported that there was no change in tissue blood flow in ONH measured by LSFG after trabeculectomy 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

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Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma

Sasaki

Higashide²,

Takeshima³

et al. 2022

Sci Rep

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A prospective study was conducted on 33 eyes of 33 patients with open-angle glaucoma who underwent trabeculectomy to investigate hemodynamic changes in the temporal optic nerve head (ONH) and peripapillary atrophy (PPA) after trabeculectomy. Laser speckle flowgraphy of ONH and PPA was performed at baseline and at 1, 3, and 6 months postoperatively. The waveforms of the mean blur rate in the tissue area (MT) in the temporal ONH, βPPA (with Bruch’s membrane), and γPPA (without Bruch’s membrane) were evaluated. Mean intra-ocular pressure (IOP) decreased from 19.1 ± 0.8 to 8.5–9.6 ± 0.7 mmHg at postoperative visits. The average MT in the βPPA region increased significantly at all postoperative time points, whereas those in the ONH and γPPA regions remained unchanged. The blowout score (BOS) increased significantly, and the resistivity index decreased significantly at all time points in all regions, which was associated with decreased IOP. The current study showed two novel findings: MT increased after trabeculectomy only in βPPA, where the choroid was present. IOP decrease-associated BOS increase occurred postoperatively in all regions, which indicates that IOP reduction may decrease vascular transmural pressure and contribute to stable blood flow uniformly, despite structural differences between the regions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma

Sasaki

Higashide²,

Takeshima³

et al. 2022

Sci Rep

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The relationship between choroidal blood flow and glaucoma progression in a Japanese study population

et al. 2022

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Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation

et al. 2022

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Purpose The aim of this study is to investigate changes in choroidal and optic nerve morphological parameters following MicroShunt PreserFlo implantation. The secondary aim is to investigate how the structural changes relate to the decrease in intraocular pressure (IOP). Methods Prospective observational study on 15 eyes with glaucoma requiring MicroShunt implantation. Optical coherence tomography was used to measure macular choroidal thickness (MCT), peripapillary choroidal thickness (PCT), lamina cribrosa depth (LCD), cup depth and prelaminar tissue thickness (PLT), before and one day after surgery. Results were expressed in median and interquartile range (IQR) and correlated with IOP results. Results The IOP decreased from a median of 25 (IQR = 11) mmHg to 8 (IQR = 2) mmHg the day after surgery. Median MCT increased after MicroShunt implantation from 252.1 (IQR = 156.4) µm to a postoperative value of 318.1 (IQR = 166.6) µm (p < 0.001), with a median increase of + 87.7 µm (+ 26.4%). PCT increased from 157.2 (IQR = 109.1) µm before surgery to 206.0 (IQR = 136.1) µm after surgery (p < 0.001). Moreover, we found a significant post-operative decrease in cup depth (median reduction of − 29.3 µm, p < 0.001) and an increase in PLT (median increase of 27.3 µm, p = 0.028). On the other side, LCD reduction 24 h after surgery didn’t reach any statistical significance. Conclusion PreserFlo implantation determines retinal structural changes which appear similar to those caused by traditional filtering surgery, confirming the effectiveness of this device, meantime carrying a much smaller complications rate when compared to trabeculectomy.

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Relationship Between Changes in the Choroidal Structure and Blood Flow of the Macula After Trabeculectomy

Cited by 5 publications

References 30 publications

Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma

Waveform changes of laser speckle flowgraphy in the temporal optic nerve head and peripapillary atrophy after trabeculectomy in open-angle glaucoma

The relationship between choroidal blood flow and glaucoma progression in a Japanese study population

Early evaluation of optic nerve head morphology and choroidal thickness after PreserFlo MicroShunt implantation

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