Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Olszanecka-Glinianowicz, Magdalena; Owczarek, Aleksander; Bożentowicz-Wikarek, Maria; Brzozowska, Aniceta; Mossakowska, Małgorzata; Zdrojewski, Tomasz; Grodzicki, Tomasz; Wiȩcek, Andrzej; Chudek, Jerzy

doi:10.1016/j.metabol.2014.07.013

Cited by 20 publications

(13 citation statements)

References 48 publications

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“…Levels of eNAMPT declined with age and were associated with nutritional status, visceral obesity and inflammation. 147 Several theories have been postulated to explain the declining levels of NAMPT and NAD with ageing. As discussed earlier, NAMPT is a major product of the action of the circadian transcription factors BMAL1 and CLOCK.…”

Section: Nampt and Ageingmentioning

confidence: 99%

Physiological and pathophysiological roles of NAMPT and NAD metabolism

et al. 2015

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Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in cellular redox reactions and is a substrate for NAD-dependent enzymes. In various metabolic disorders and during ageing, levels of NAD are decreased. Through its NAD-biosynthetic activity, NAMPT influences the activity of NAD-dependent enzymes, thereby regulating cellular metabolism. In addition to its enzymatic function, extracellular NAMPT (eNAMPT) has cytokine-like activity. Abnormal levels of eNAMPT are associated with various metabolic disorders. NAMPT is able to modulate processes involved in the pathogenesis of obesity and related disorders such as nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) by influencing the oxidative stress response, apoptosis, lipid and glucose metabolism, inflammation and insulin resistance. NAMPT also has a crucial role in cancer cell metabolism, is often overexpressed in tumour tissues and is an experimental target for antitumour therapies. In this Review, we discuss current understanding of the functions of NAMPT and highlight progress made in identifying the physiological role of NAMPT and its relevance in various human diseases and conditions, such as obesity, NAFLD, T2DM, cancer and ageing.

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Section: Nampt and Ageingmentioning

confidence: 99%

Physiological and pathophysiological roles of NAMPT and NAD metabolism

et al. 2015

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“…In our recently published study, we have shown that plasma visfatin/NAMPT levels are associated with age, systemic microinflammation, and IR regardless of sex, and with nutritional status only in women. 19 The aim of the present study was to assess the association between the number and type of MS components and circulating plasma visfatin/ NAMPT levels in elderly population.PAtIents And methods study design and setting This substudy was based on 2733 banked samples from the PolSenior study 18 stored at -70°C. The PolSenior study conducted in the years 2008 and 2011 recruited 6 age cohorts of a similar size (65-69 years, 70-74 years, 75-79 years, 80-84 years, 85-89 years, and ≥90 years).…”

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confidence: 99%

mentioning

confidence: 99%

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Kocełak¹,

Olszanecka-Glinianowicz²,

Owczarek³

et al. 2015

Polish Archives of Internal Medicine

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IntroductIon Visceral adipose tissue is the main source of circulating proinflammatory adipokine, visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT), whose role in the pathogenesis of metabolic syndrome (MS) components such as hypertension and carbohydrate and lipid disturbances is still uncertain, due to commonly used low specific C-terminal immunoassays to determine visfatin/ NAMPT levels.objectIves The aim of the study was to assess the association between the occurrence of MS components and circulating visfatin/NAMPT levels in elderly population.PAtIents And methods The analysis included 2174 elderly participants of the PolSenior study without heart failure, severe chronic kidney disease, cancer, and malnutrition. MS was defined according to the modified International Diabetes Federation criteria. Plasma visfatin/NAMPT concentrations were measured by a highly specific enzyme-linked immunosorbent assay. Additionally, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and insulin levels were assessed, and the homeostasis model assessment for insulin resistance was calculated.results Women were diagnosed with MS more often than men (71.2% vs 56.8%; P <0.001) and had a greater prevalence of all MS components except for type 2 diabetes. Women with MS had higher concentrations of hsCRP and IL-6 than those without MS. Visfatin/NAMPT concentrations were higher in women with MS than in those without MS (1.06 ng/ml [0.65-1.87] vs 0.85 ng/ml [0.54-1.40]; P <0.001), but no differences were observed in men (0.97 ng/ml [0.59-1.61] vs 0.90 ng/ml [0.56-1.60], respectively; P = 0.5). In women, there was a stronger association between the number of components of MS and increased plasma visfatin/NAMPT levels than in men.conclusIons Plasma visfatin/NAMPT levels are increased only in elderly women with MS. It is difficult to distinguish the components of MS specifically associated with increased visfatin/NAMPT levels. 403assay (ELISA) kits in plasma samples of a large group of elderly subjects, participants of the PolSenior study, 18 may provide new data on the role of visfatin/NAMPT in MS. In our recently published study, we have shown that plasma visfatin/NAMPT levels are associated with age, systemic microinflammation, and IR regardless of sex, and with nutritional status only in women. 19 The aim of the present study was to assess the association between the number and type of MS components and circulating plasma visfatin/ NAMPT levels in elderly population.PAtIents And methods study design and setting This substudy was based on 2733 banked samples from the PolSenior study 18 stored at -70°C. The PolSenior study conducted in the years 2008 and 2011 recruited 6 age cohorts of a similar size (65-69 years, 70-74 years, 75-79 years, 80-84 years, 85-89 years, and ≥90 years). Trained nurses visited a total of 4979 participants 3 times to conduct a questionnaire survey, comprehensive geriatric assessment, and body mass, height, waist circumference, and blood pressure (BP) measurements. In addi...

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“…Therefore, we have carried out visfatin/NAMPT assessment by using ELISA method in plasma samples of a large group of elderly subjects with a high prevalence of CKD and who were participants of the PolSenior study [12]. On the basis of the results of previous analyses, we have shown that visfatin/NAMPT levels are affected by insulin resistance, systemic inflammation, age in both sexes, and modestly by nutritional status in women [13].…”

Section: Introductionmentioning

confidence: 99%

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration is not related to kidney function in elderly subjects

Kocełak

Olszanecka-Glinianowicz

Owczarek

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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IntroductIon Visceral adipose tissue is the main source of circulating proinflammatory adipokine, visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT), whose role in the pathogenesis of metabolic syndrome (MS) components such as hypertension and carbohydrate and lipid disturbances is still uncertain, due to commonly used low specific C-terminal immunoassays to determine visfatin/ NAMPT levels. objectIves The aim of the study was to assess the association between the occurrence of MS components and circulating visfatin/NAMPT levels in elderly population. PAtIents And methods The analysis included 2174 elderly participants of the PolSenior study without heart failure, severe chronic kidney disease, cancer, and malnutrition. MS was defined according to the modified International Diabetes Federation criteria. Plasma visfatin/NAMPT concentrations were measured by a highly specific enzyme-linked immunosorbent assay. Additionally, high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and insulin levels were assessed, and the homeostasis model assessment for insulin resistance was calculated. results Women were diagnosed with MS more often than men (71.2% vs 56.8%; P <0.001) and had a greater prevalence of all MS components except for type 2 diabetes. Women with MS had higher concentrations of hsCRP and IL-6 than those without MS. Visfatin/NAMPT concentrations were higher in women with MS than in those without MS (1.06 ng/ml [0.65-1.87] vs 0.85 ng/ml [0.54-1.40]; P <0.001), but no differences were observed in men (0.97 ng/ml [0.59-1.61] vs 0.90 ng/ml [0.56-1.60], respectively; P = 0.5). In women, there was a stronger association between the number of components of MS and increased plasma visfatin/NAMPT levels than in men. conclusIons Plasma visfatin/NAMPT levels are increased only in elderly women with MS. It is difficult to distinguish the components of MS specifically associated with increased visfatin/NAMPT levels. orIGInAl ArtIcle orIGInAl ArtIcle Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT)... 403 assay (ELISA) kits in plasma samples of a large group of elderly subjects, participants of the Pol-Senior study, 18 may provide new data on the role of visfatin/NAMPT in MS. In our recently published study, we have shown that plasma visfa-tin/NAMPT levels are associated with age, sys-temic microinflammation, and IR regardless of sex, and with nutritional status only in women. 19 The aim of the present study was to assess the association between the number and type of MS components and circulating plasma visfatin/ NAMPT levels in elderly population. PAtIents And methods study design and setting This substudy was based on 2733 banked samples from the PolSenior study 18 stored at-70°C. The PolSenior study conducted in the years 2008 and 2011 recruited 6 age cohorts of a similar size (65-69 years, 70-74 years, 75-79 years, 80-84 years, 85-89 years, and ≥90 years). Trained nurses visited a total of 4979 participants 3 times to conduct a questionnaire survey, comprehensive ger...

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Relationship between circulating visfatin/NAMPT, nutritional status and insulin resistance in an elderly population – results from the PolSenior substudy

Cited by 20 publications

References 48 publications

Physiological and pathophysiological roles of NAMPT and NAD metabolism

Physiological and pathophysiological roles of NAMPT and NAD metabolism

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration in elderly subjects with metabolic syndrome

Plasma visfatin/nicotinamide phosphoribosyltransferase (visfatin/NAMPT) concentration is not related to kidney function in elderly subjects

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