Relationship between estrogen and body composition, energy, and endocrine factors in obese women with normal and low REE

Ahmadi, S; Eshraghian, Mohammad Reza; Hedayati, Mehdi; Pishva, Hamideh

doi:10.1016/j.steroids.2017.12.008

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…However, gender differences regarding the relationship between dietary habits and obesity are inconsistent. The biological actions of endogenous estrogen may also be influenced by macronutrient intake [ 34 ]. Estrogen was associated with changes in body weight in women [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Roles of Sedentary Behaviors and Unhealthy Foods in Increasing the Obesity Risk in Adult Men and Women: A Cross-Sectional National Study

et al. 2018

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Sedentary behaviors and dietary intake are independently associated with obesity risk. In the literature, only a few studies have investigated gender differences for such associations. The present study aims to assess the association of sedentary behaviors and unhealthy foods intake with obesity in men and women in a comparative manner. The analysis presented in this study was based on the data from a population-based, cross-sectional, nationally representative survey (Indonesian Basic Health Research 2013/RISKESDAS 2013). In total, 222,650 men and 248,590 women aged 19–55 years were enrolled. A validated questionnaire, physical activity card, and food card were used for the assessments. The results showed that the prevalence of obesity (body mass index of ≥27.5 kg/m2) was higher in women (18.71%) than in men (8.67%). The mean body mass index in women tended to be higher than in men. After adjusting for age and education, the gender effect on obesity persisted in women and was more significant than in men. There was also a positive and significant effect on obesity of sedentary behaviors and unhealthy foods intake. Moreover, fatty and fried foods displayed a positive multiplicative interaction, increasing obesity risk in women more than in men and indicating a possible dietary risk in in women in relation to obesity. The study suggests that the implementation of educational programs on nutrition and physical activity is particularly important for promoting a healthy body weight among Indonesian women.

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Section: Discussionmentioning

confidence: 99%

Roles of Sedentary Behaviors and Unhealthy Foods in Increasing the Obesity Risk in Adult Men and Women: A Cross-Sectional National Study

et al. 2018

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“…10,89 Besides, there is a potential correlation between body weight and estrogen levels in females. 90 Therefore, if females were used, estrogen level would be a profound factor affecting bone health and serum TNF-α levels in rats thus greatly increasing research difficulties. Moreover, males seem more susceptible to obesity after long-term high-fat feeding.…”

Section: Discussionmentioning

confidence: 99%

Interaction between ferroptosis and TNF‐α: Impact in obesity‐related osteoporosis

Chen

Liu

et al. 2023

The FASEB Journal

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The relationship of obesity and osteoporosis has been widely studied over the past years. However, the implications of obesity for bone health remain controversial, and the underlying molecular mechanism is not yet fully understood.This study demonstrated that high-fat diet-induced obesity leads to significantly decreased bone volume/tissue volume (BV/TV), trabecular number (Tb.N), and cortical thickness (Ct.Th) of male rat femur after mechanical loading effects of body weight were controlled. HFD-induced obese rats exhibited attenuated expression of ferroptosis inhibitory protein SLC7A11 and GPX4 in bone tissues, which was correlated with elevated serum TNF-α concentration. Ferroptosis inhibitor administration could effectively rescue decreased osteogenesis-associated type H vessels and osteoprogenitors, and downregulate serum levels of TNF-α to ameliorate bone loss in obese rats. Since ferroptosis and TNF-α both affect bone and vessel formation, we further investigated the interaction between ferroptosis and TNF-α, and its impact in osteogenesis and angiogenesis in vitro. In human osteoblast-like MG63 and umbilical vein endothelial cells (HUVEC), TNF-α/ TNFR2 signaling promoted cystine uptake and GSH biosynthesis to provide protection against low-dose ferroptosis inducer erastin. While, TNF-α/TNFR1 facilitated ferroptosis in the presence of high-dose erastin through ROS accumulation.

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“…This could be related to the fact that even active women presented a relevant overweight BMI. It is well established that estrogen plays an important role in regulating body fat in women (Ahmadi et al 2018). However, studies show that in obese women, many protective effects of estrogen are lost (McGill et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Gender-related differences in the modulation of anthropometric, biochemical, and immune markers by physical activity in hypertensive and diabetic individuals

Santos

Ribeiro

Lopes

et al. 2021

An. Acad. Bras. Ciênc.

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Systemic arterial hypertension (SAH) and type 2 diabetes mellitus (T2DM) compose the two major noncommunicable chronic infl ammatory diseases. Physical activity has been shown as a promising complementary approach to control the systemic infl ammation. However, it is still unclear whether this modulation is genderdependent. The objective of this study was evaluate the gender-related infl uence of physical activity on the infl ammatory response and biochemical profi le of individuals with SAH and T2DM. An international physical activity questionnaire was applied to 376 individuals diagnosed with SAH and T2DM in order to access their exercises routine and was evaluated the infl uence of physical activity in biochemical, anthropometrical, and immunological markers involved in these disorders in men and women. Even though active individuals have exhibited lower serum levels of IL-1β, IFN-γ, TNF-α, and IL-17A, the ratios between IL-10 and all infl ammatory cytokines were higher in men than in women. Physically active individuals also demonstrated increased HDL/LDL and HDL/ VLDL ratios. Moreover, multiple correlations revealed that in active women both IL-10 and TNF-α serum levels positively correlate with fasting glucose levels, and were negatively associated with HDL levels. Our fi ndings suggest that gender-related differences dictate a distinct crosstalk between infl ammatory and biochemical markers in physically active individuals.

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Relationship between estrogen and body composition, energy, and endocrine factors in obese women with normal and low REE

Cited by 8 publications

References 35 publications

Roles of Sedentary Behaviors and Unhealthy Foods in Increasing the Obesity Risk in Adult Men and Women: A Cross-Sectional National Study

Roles of Sedentary Behaviors and Unhealthy Foods in Increasing the Obesity Risk in Adult Men and Women: A Cross-Sectional National Study

Interaction between ferroptosis and TNF‐α: Impact in obesity‐related osteoporosis

Gender-related differences in the modulation of anthropometric, biochemical, and immune markers by physical activity in hypertensive and diabetic individuals

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