Relationship Between Fatigue and Nutritional Status in Patients with Cancer Undergoing Radiotherapy

Yang, YoungSoon

doi:10.4040/jkan.2003.33.4.478

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…Fatigue can occur as an acute or chronic state, most often observed in specific medical disorders such as cancer, heart failure, and stroke [30,31]. Impaired nutritional status has frequently been linked to fatigue in cancer patients [32,33]. Stobäus et al moreover showed that recent protein intake in cancer patients is associated with higher fatigue, implying that not only nutritional status but also acute dietary intake has an effect on fatigue [34].…”

Section: Discussionmentioning

confidence: 99%

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

et al. 2019

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Although malnutrition is frequent in the old, little is known about its association with fatigue. We evaluated the relation of self-reported severe weight loss with fatigue and the predictors for fatigue in old patients at hospital discharge. Severe weight loss was defined according to involuntary weight loss ≥5% in the last three months. We determined fatigue with the validated Brief Fatigue Inventory questionnaire. The regression analyses were adjusted for age, sex, number of comorbidities, medications/day, and BMI. Of 424 patients aged between 61 and 98 y, 34.1% had severe weight loss. Fatigue was higher in patients with severe weight loss (3.7 ± 2.3 vs. 3.2 ± 2.3 points, p = 0.021). In a multinomial regression model, weight loss was independently associated with higher risk for moderate fatigue (OR:1.172, CI:1.026–1.338, p = 0.019) and with increased risk for severe fatigue (OR:1.209, CI:1.047–1.395, p = 0.010) together with the number of medications/day (OR:1.220, CI:1.023-1.455, p = 0.027). In a binary regression model, severe weight loss predicted moderate-to-severe fatigue in the study population (OR:1.651, CI:1.052-2.590, p = 0.029). In summary, patients with self-reported severe weight loss at hospital discharge exhibited higher fatigue levels and severe weight loss was an independent predictor of moderate and severe fatigue, placing these patients at risk for impaired outcome in the post-hospital period.

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Section: Discussionmentioning

confidence: 99%

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

et al. 2019

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“…This finding warrants additional investigation because the data on the relationship between BMI and fatigue are inconclusive 18,57,58…”

Section: Discussionmentioning

confidence: 99%

Trajectories of Fatigue in Patients With Breast Cancer Before, During, and After Radiation Therapy

et al. 2010

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“…For example, in a study of 134 patients with breast cancer, women who received chemotherapy treatment reported greater fatigue severity than women receiving radiotherapy (Donovan et al 2004). Other studies have found that patients receiving both radiotherapy and chemotherapy treatment report higher fatigue scores than those receiving single modality treatment (Yang 2003, Bower et al 2006, Jereczek-Fossa et al 2007, indicating the probability of some association between treatment intensity and fatigue although the exact relationship is not clear.…”

Section: Treatment-related Factorsmentioning

confidence: 99%

“…When caloric intake is insufficient, the protein stored in muscles is broken down and used as an energy source. This type of malnutrition can lead to immune system compromise and possibly the development of fatigue (Yang 2003). Progressive weight loss with muscle wasting, called cachexia, is manifested clinically by fatigue (Brown 2002).…”

Section: Poor Nutritionmentioning

confidence: 99%

Cancer-Related Fatigue: A Review and a Conceptual Framework to Guide Therapists' Understanding

Purcell

Fleming

Haines

et al. 2009

British Journal of Occupational Therapy

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Cancer-related fatigue is reported as the most common and distressing symptom experienced by people with cancer. There is limited research published to guide occupational therapists working with people with cancer to help address this distressing symptom. This article reviews literature on cancer-related fatigue and identifies several factors associated with the development of fatigue, including underlying medical factors and other factors. The underlying medical factors reported in the literature include biomedical mechanisms, such as anaemia, proinflammatory cytokines and specific cellular processes; disease-related factors; treatment-related factors; and comorbid conditions. Other factors reviewed include physical or behavioural factors, such as poor nutrition, decreased activity, sleep disturbance and pain; psychological factors, including anxiety and depression; and sociodemographic factors, such as social support, employment and education. The review identified a variety of factors associated with cancer-related fatigue, which must be considered by occupational therapists working with people with cancer. This presents a challenge to the clinical reasoning of occupational therapists attempting to treat such people. A framework of factors contributing to cancer-related fatigue is proposed in order to guide both the practice of occupational therapists working with adults with cancer and future research in this area.

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Relationship Between Fatigue and Nutritional Status in Patients with Cancer Undergoing Radiotherapy

Cited by 6 publications

References 16 publications

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

Severe Weight Loss and Its Association with Fatigue in Old Patients at Discharge from a Geriatric Hospital

Trajectories of Fatigue in Patients With Breast Cancer Before, During, and After Radiation Therapy

Cancer-Related Fatigue: A Review and a Conceptual Framework to Guide Therapists' Understanding

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