Relationship between high serum ferritin level and glaucoma in a South Korean population: the Kangbuk Samsung health study

Gye, Hyo Jung; Kim, Joon Mo; Yoo, Chungkwon; Shim, Seong Hee; Won, Yu Sam; Sung, Ki Chul; Lee, Mi Yeon; Park, Ki Ho

doi:10.1136/bjophthalmol-2015-307678

Cited by 27 publications

(31 citation statements)

References 24 publications

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“…The retrospective cross‐sectional Kangbuk Samsung health study ( N = 164 029) found similar results in men (highest quartile OR [95% CI]: 1.18 [1.03–1.34]; Gye et al. ). In contrast, in female patients with iron deficiency anaemia, a thinner peripapillary retinal nerve fibre layer was reported compared to controls; however, it is not known whether it is the iron deficiency or the anaemia that caused this finding (Cikmazkara & Ugurlu ).…”

Section: Resultsmentioning

confidence: 77%

“…Regarding total and dietary iron consumption, the same research group reported in another study (N = 6316) an increasing OR per quintile of total consumption of iron, but a decreasing OR per quintile of dietary iron ). In another cross-sectional population-based study (N = 17 476), it was shown that a high serum ferritin level was associated with a higher risk of glaucoma (highest quartile OR [95% CI]: 1.89 [1.32-2.72]; Lin et al 2014 Gye et al 2016). In contrast, in female patients with iron deficiency anaemia, a thinner peripapillary retinal nerve fibre layer was reported compared to controls; however, it is not known whether it is the iron deficiency or the anaemia that caused this finding (Cikmazkara & Ugurlu 2016).…”

Section: Minerals and Trace Elementsmentioning

confidence: 99%

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The relation between dietary intake and glaucoma: a systematic review

Ramdas

2018

Acta Ophthalmologica

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Intake of selenium and iron may increase the risk of glaucoma, though, only few studies have been done on this topic. Nitric oxide present in other dark green leafy vegetables seems to have a beneficial effect on glaucoma. However, the evidence for an association of dietary intake with glaucoma is still not strong. More (longitudinal and randomized clinical trials) studies are required to make the presented findings clinically applicable.

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Section: Resultsmentioning

confidence: 77%

Section: Minerals and Trace Elementsmentioning

confidence: 99%

The relation between dietary intake and glaucoma: a systematic review

Ramdas

2018

Acta Ophthalmologica

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“…Our cohort consisted of mostly middle aged Asians with higher socioeconomic and education levels and urban habitation with the highest annual PM concentrations in the world. Thus, these characteristics can contribute to more increase in the amount of mobilized iron especially in men than women in our cohort [8,[21][22][23][24][25][26]. The large difference in serum ferritin level between men and women can contribute to much higher lifetime iron stores in men than in women.…”

Section: Study Design and Populationmentioning

confidence: 83%

“…all the previous studies enrolled females, who represented more than half of the total number of subjects, in contrast to this study. Although serum ferritin decreases with age in males and increases with age in females, the factor with the greatest effect on the discrepant level of ferritin is sex [24,36]. Hormonal effects and increased iron loss can cause physiological differences in iron homeostasis and biomarker distributions between males and females.…”

Section: Plos Onementioning

confidence: 99%

Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study

et al. 2020

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Objectives Though elevated ferritin level and decreased lung function both predispose people to cardio-metabolic disease, few reports have investigated the association between them. Furthermore, it remains unclear whether the association reflects a change in iron stores or an epiphenomenon reflecting metabolic stress. Therefore, we looked for possible associations between ferritin, iron, and transferrin saturation (TSAT) and lung function to clarify the role of iron-related parameters in healthy men. Methods We conducted a cohort study of 42,927 healthy Korean men (mean age: 38.6 years). Percent predicted forced expiratory volume in one second (FEV1%) and forced vital capacity (FVC%) were categorized into quartiles. Adjusted odds ratios (aORs) and 95% confidence intervals (using the highest quartile as reference) were calculated for hyperferritinemia, high iron, and high TSAT after controlling for potential confounders. Results The median ferritin level was 199.8 (141.5-275.6) ng/mL. The prevalence of hyperferritinemia (defined as >300 ng/mL) was 19.3%. Subjects with hyperferritinemia had lower FEV1% and FVC% than those with normal ferritin level with a slight difference, but those were statistically significant (99.22% vs.99.61% for FEV1%, p = 0.015 and 98.43% vs. 98.87% for

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“…In the low BMI group of females, those with POAG had lower intakes of most of nutrients than those without POAG, but this was not true for males. Some studies have reported differences in the prevalence and risk factors for OAG between males and females [3,10,48,49]. Estrogen-related factors such as the effect on IOP and their neuroprotective effects have been proposedas possible mechanisms to explain the observed sex differences in POAG prevalence [50,51].…”

Section: Discussionmentioning

confidence: 99%

Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

et al. 2020

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To investigate the association between nutrient intake and primary open angle glaucoma (POAG) in Koreans, a population-based, cross-sectional survey, the Korean National Health and Nutrition Examination Survey, was analyzed. Glaucoma diagnosis was based on criteria established by the International Society of Geographic and Epidemiologic Ophthalmology. Multivariate regression analysis was used to assess the correlation between dietary intake and the prevalence of POAG in all enrolled subjects. In the low Body mass index(BMI) group (BMI <18.5), females with POAG had significantly lower intakes of energy, protein, fat, carbohydrate, ash, calcium, phosphorus, sodium, potassium, vitamin A, B-carotene, thiamin, riboflavin, and vitamin C than their non-glaucoma counterparts, based on a multivariate logistic regression analysis (all p < 0.05). In females with a medium BMI (18.5 ≤ BMI < 23), POAG showed a significant association with lower food intake, energy, protein, calcium, phosphorus, potassium, thiamin and niacin. (all p < 0.05). Lower protein thiamine intake in medium BMI males was related to POAG. Low dietary intake of several nutrients showed an association with glaucoma in low BMI female subjects. An insufficient intake of certain nutrients may be associated with an increased risk of glaucoma in Koreans. Further large-scale cohort studies are needed to determine how specific nutrients alter the risk of glaucoma.

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Relationship between high serum ferritin level and glaucoma in a South Korean population: the Kangbuk Samsung health study

Abstract: High serum ferritin level was associated with a high risk of glaucoma in men, but not in women. Because serum ferritin is related to oxidative stress and inflammation, it might play a role in glaucoma development.

Cited by 27 publications

References 24 publications

The relation between dietary intake and glaucoma: a systematic review

The relation between dietary intake and glaucoma: a systematic review

Decreased lung function is associated with elevated ferritin but not iron or transferrin saturation in 42,927 healthy Korean men: A cross-sectional study

Relationships between Obesity, Nutrient Supply and Primary Open Angle Glaucoma in Koreans

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