Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs

Selective chiral inhibitors of 5‐lipoxygenase with anti‐inflammatory activity

“…Studies in animal models of inflammation have demonstrated that the anti-inflammatory potency of NSAIDs correlates with their potency as cyclooxygenase inhibitors. In addition, with optically-active NSAIDs, anti-inflammatory activity and cyclo-oxygenase inhibition have been shown to reside in the same enantiomer (Ham et al, 1972;Tomlinson et al, 1972). Similarly we have previously shown, using arachidonic acid-induced oedema in rabbit skin, that the anti-inflammatory efficacy of a series of redox-based compounds, 2-substituted indazolinones, is directly related to their potency as lipoxygenase inhibitors (Foster et al, 1990).…”

The Effect of Naproxen on Acute Mountain Sickness and Vascular Responses to Hypoxia

“…Despite our inability to correlate 6 ketr--?FrGa wit sure cr drug trials, naprexen (like aspirin and indomethacin) inhibits prctta-------glandin synthesis in vitro and in vivo (22,26,27 Our findings are contrasted to dexamethasone, which was reported to have prevented AIMS and blocked retinal artery dilatation during hypovia (5).…”

Mechanism of action of colchicine

“…T h e suppressive effects of phenylbutazone and indomethacin in this model of inflammation are well known. Their mechanism of action is not completely understood but is believed to be mediated through the suppression of prostaglandin biosynthesis (17,18). T h e slope of the oral dose-response regression line for colchicine differs from that of indomethacin and phenylbutazone, suggesting a different mechanism of action.…”