Relationship between periodontal inflammation and fetal growth in pregnant women: a cross-sectional study

Takeuchi, Noriko; Ekuni, Daisuke; Irie, Koichiro; Furuta, Michiko; Tomofuji, Takaaki; Morita, Manabu; Watanabe, Tatsuo

doi:10.1007/s00404-012-2660-4

Cited by 21 publications

(16 citation statements)

References 35 publications

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“…For example, active periodontal inflammation, as determined by bleeding on probing, has been reported to correlate with reductions in fetal femur length, birth weight and birth length (Takeuchi et al. ). Indeed, it has even been suggested that periodontal disease severity may predict adverse pregnancy outcome (Al Habashneh et al.…”

mentioning

confidence: 99%

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Gogeneni

Buduneli

Ceyhan-Öztürk

et al. 2015

J Clinic Periodontology

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Aim Gestational diabetes mellitus (GDM), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. We set out to monitor the interactions of gingivitis and GDM with respect to oral infection and the systemic inflammatory burden. Materials and Methods Four case–control groups (n = 117) were recruited, (1) No gingivitis, No GDM (n = 27); (2) Gingivitis, No GDM (n = 31); (3) No gingivitis, GDM (n = 21); and (4) Gingivitis, GDM (n = 38). Oral infection with three key periodontal pathogens was determined by PCR. Systemic inflammation was determined by quantification of CRP by EIA. Results Gingivitis during pregnancy was associated with oral infection with Porphyromonas gingivalis, Filifactor alocis and Treponema denticola and combinations thereof (all p < 0.01). GDM was also associated with increased infection with individual and multiple oral pathogens (all p < 0.05). Gingivitis during pregnancy led to a 325% increase in systemic CRP (mean, 2495 versus 8116 ng/ml, p < 0.01). Conclusions Diabetes and gingivitis act in concert to increase risk biomarkers for poor pregnancy outcome.

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confidence: 99%

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Gogeneni

Buduneli

Ceyhan-Öztürk

et al. 2015

J Clinic Periodontology

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“…Periodontal disease is a chronic inflammatory disease of the soft and hard tissues that support the teeth, caused by bacterial plaque and influenced by host response factors (Zi et al, 2013;Takeuchi et al, 2013;Muwazi et al, 2013). There are two main types of conditions; gingivitis and periodontitis.…”

Section: Periodontal Disease As a Potential Risk Factor For Adverse Pmentioning

confidence: 99%

Inflammation Mediators Related to Periodontal Disease and Pregnancy Outcomes: A Call for Quality of Antenatal Care While Promising Evidences Are Emerging

Faquim¹,

Oliveira²,

Silva³

et al. 2017

GJHS

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Infections may play a significant role in the induction of births and prematurity. Periodontal disease could be a risk factor for pregnancy outcomes such as preterm birth, and low birth weight. Possible mechanisms of this relationship are the production of inflammatory mediators and cytokines like C-reactive protein (CRP), prostaglandin E2 (PGE2), matrix metalloproteinases, interleukin 1 (IL-1), IL-6, and tumor necrosis factor alfa (TNF-a); the translocation of periodontal pathogens to the feto-placental unit through blood stream, a periodontal reservoir of lipopolysaccharides (LPS); and shared risk factors. Although this knowledge is just emerging, it has important implications for the health services and the healthcare delivery model. Committed health teams to an interprofessional collaborative work within the health services can raise the quality of antenatal care. Population strategies directed to prevent and control periodontal disease can increase the periodontal health of the majority of people and affect positively risk groups. These inexpensive basic measures joined with other actions at different levels could enhance the quality of antenatal care and contribute for favorable pregnancy outcomes. Further researches need to clarify the evidences on those relationships.

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“…We chose this marker in part because the “tendency for the gingiva to bleed” was the “decisive criterion” of the Gingival Index (GI) (2). Also, the population of the original GI study was pregnant women (3) and there is a higher prevalence of periodontal inflammation in women during pregnancy compared to non-pregnant women (4, 5). Therefore the aim of this study was to investigate the correlation of a salivary occult blood test (SOBT) with traditional measures from a full mouth periodontal examination (FMPE) in the detection of periodontal inflammation, with the intent to assess the feasibility of the SOBT as a measure of periodontal inflammation in a population of women during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Feasibility study of a salivary occult blood test to correlate with periodontal measures as indicators of periodontal inflammation in a population of pregnant women

Reed

Manz

Snipe

et al. 2015

Journal of Oral Science

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The purpose of this feasibility study was to investigate the correlation of a salivary occult blood test (SOBT) with traditional periodontal measures to assess the feasibility of the SOBT as a measure of periodontal inflammation in a population of women during pregnancy. Recognizing previous SOBT studies’ limitations, this study evaluated correlation of the Perioscreen® Sunstar SOBT with traditional measures from a full mouth periodontal examination. Data were collected at 3 times during pregnancy (12–14, 24–28, and 36 weeks) from women participating in an ongoing study of pregnancy and inflammation. Descriptive statistics and correlations were generated for SOBT scores with periodontal measures. Preliminary data were analyzed from 7 women with 3 visits, 7 with 2, and 9 with 1 visit’s data. For these 44 visits’ data, mean percent sites with bleeding on probing (BOP) for SOBT scores = 0, 2 and 5 was 58%±18%, 68%±14%, and 72%±19%, respectively. Correlations for percent of sites with BOP and continuous SOBT score was 0.301, p-value=0.0469 and dichotomous SOBT was 0.32, p-value=0.0339. Results for feasibility, measured as recruitment of participants, acceptance of protocols, distribution of periodontal inflammation and preliminary correlations, support SOBT as a correlated marker of periodontal inflammation in this population of pregnant women.

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Relationship between periodontal inflammation and fetal growth in pregnant women: a cross-sectional study

Abstract: These results suggest that periodontal inflammation is correlated with fetal femur length, birth weight, and birth length.

Cited by 21 publications

References 35 publications

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Increased infection with key periodontal pathogens during gestational diabetes mellitus

Inflammation Mediators Related to Periodontal Disease and Pregnancy Outcomes: A Call for Quality of Antenatal Care While Promising Evidences Are Emerging

Feasibility study of a salivary occult blood test to correlate with periodontal measures as indicators of periodontal inflammation in a population of pregnant women

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