Relationship between periodontitis and rheumatoid arthritis in Vietnamese patients

Nguyen, Van Bich; Nguyễn, Thủy Thu; Huynh, Nam Cong-Nhat; Le, Thu Anh; Hoang, Hung Tu

doi:10.1080/00016357.2020.1747635

Cited by 13 publications

(20 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This was a study comparing periodontitis in RA participants to OA controls. To date, only limited studies using a similar control group [6,[21][22][23]. The National Oral Health Survey 2010 for Malaysia estimated that 48.5% of adults in Malaysia have periodontitis [24].…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study

et al. 2021

View full text Add to dashboard Cite

Patients with rheumatoid arthritis (RA) experience a higher prevalence of periodontitis. This study aimed to examine the variation of periodontitis experienced with different serotypes suffered by RA patients and to examine the relationship between the different medications taken for RA that may influence this relationship. Two hundred and sixty RA and control participants underwent standardized periodontal examinations. Medical, serological and radiological (Sharp/van der Heijde) records were assessed. Functional status was assessed using the administered Health Assessment Questionnaire. Moreover, disease parameters, including disease activity (DAS28-ESR) and anti-citrullinated protein antibodies (ACPA) and rheumatoid factor (RF) seropositivity were evaluated. Periodontitis was higher in RA (71.54%) compared with controls (54.62%). The stage of periodontitis experienced by ACPA-positive participants were higher than APCA-negative participants. The probing pocket depth and recession experienced by RF-positive participants were higher than those who were RF-negative. RA participants on methotrexate had lower clinical attachment loss and lower periodontal probing depth compared with participants on a combination methotrexate and other disease-modifying antirheumatic drugs. Participants taking corticosteroids had lower gingival index scores. The association between seropositivity and the type of medications taken with periodontal health parameters in this group of patients suggests that both seropositivity and medications taken are important modifiers in the relationship between periodontitis and RA.

show abstract

Section: Discussionmentioning

confidence: 99%

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Periodontal disease assessment was conducted before SRP (T0) and after 6 weeks (T6), as in our previous studies [15]. Plaque index (PLI), gingival index (GI), probing pocket depth (PPD), clinical attachment loss (CAL), and bleeding on probing (BOP) were evaluated at six positions in all teeth (mesio-buccal, buccal, disto-buccal, mesio-lingual, lingual, and disto-lingual).…”

Section: Outcomes Periodontal Clinical Parametersmentioning

confidence: 99%

Hyaluronic acid 0.2% application enhanced periodontitis treatment in non-surgical phase

Nguyễn¹,

Ho²,

Huynh³

et al. 2021

jos

View full text Add to dashboard Cite

Introduction: Topical hyaluronic acid (HA) has been considered as an adjuvant agent for periodontitis (PD). Objectives: This study aimed to assess the clinical effects of subgingival application of 0.2% HA gel, following scaling and root planning (SRP) in PD patients. Material and methods: In this randomized split-mouth study, 733 periodontal pockets of 28 patients with PD were investigated. They were divided into control and experimental groups. The experimental group received subgingival administration of 1 ml 0.2% HA gel into each pocket immediately after SRP, and then after 1 week, 2 weeks, and 3 weeks. Clinical parameters and subgingival plaque were assessed at baseline and 6 weeks after SRP. Quantitative real-time polymerase chain reaction for Porphyromonas gingivalis (Pg), Treponema denticola (Td), Fusobacterium nucleatum (Fn), and Tannerella forsythia (Tf) were also performed. Results: After 6 weeks, there were significant decreases in clinical parameters, and the number of Fn in the experimental group compared to the control group (p < 0.05). The number of Pg, Td, and Tf decreased significantly in both groups, with no significant difference between the 2 cohorts (p > 0.05). Conclusions:The topical application of HA gel in periodontal pockets after SRP may have a beneficial effect in PD patients. This additional treatment appears to help reducing 2 types of bacteria (Tf and Fn) better than non-surgical treatment only. Trial registration: Identifier NCT04675385 in ClinicalTrials.gov.

show abstract

“…An accumulating body of evidence has shown that untreated periodontitis is associated with several systemic conditions such as diabetes, rheumatoid arthritis, adverse pregnancy outcomes, renal diseases, and coronary heart disease (CHD), including myocardial infarction (MI) and angina pectoris (Potempa et al, 2017;Deschamps-Lenhardt et al, 2019;Joshi et al, 2019;Preshaw & Bissett, 2019;Nguyen et al, 2020;Olsen, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Periodontitis is characterized by chronic inflammation of the tooth‐supporting structures, caused by dysbiotic subgingival microbiota and worsened by risk factors such as smoking and uncontrolled diabetes. An accumulating body of evidence has shown that untreated periodontitis is associated with several systemic conditions such as diabetes, rheumatoid arthritis, adverse pregnancy outcomes, renal diseases, and coronary heart disease (CHD), including myocardial infarction (MI) and angina pectoris (Potempa et al, 2017; Deschamps‐Lenhardt et al, 2019; Joshi et al, 2019; Preshaw & Bissett, 2019; Nguyen et al, 2020; Olsen, 2021).…”

Section: Introductionmentioning

confidence: 99%

Serum antibody response against periodontal bacteria and coronary heart disease: Systematic review and meta‐analysis

Joshi

Bapat

Anderson

et al. 2021

J Clinic Periodontology

View full text Add to dashboard Cite

Aim The present systematic review and meta‐analysis assessed the strength of a reported association between elevated serum anti‐periodontal bacterial antibody responses and coronary heart disease (CHD). Materials and methods Twenty original studies were identified after systematically searching five databases. The majority (n = 11) compared serum anti‐Porphyromonas gingivalis (Pg) and/or anti‐Aggregatibacter actinomycetemcomitans (Aa) IgG antibody responses between CHD patients and control participants. The strength of the association between serum anti‐Pg antibodies and CHD (n = 10) and serum anti‐Aa antibodies and CHD (n = 6) was investigated using a meta‐analysis approach separately. Results Most studies (61%) reported that the serum IgG antibody responses were elevated in CHD patients than in controls. The meta‐analyses showed a significant association between elevated serum IgG antibody responses (anti‐Pg and anti‐Aa) and CHD, with pooled odds ratios of 1.23 [95% confidence interval (CI): 1.09–1.38, p = .001] and 1.25 (95% CI: 1.04–1.47, p = .0004), respectively. Conclusions A modest increase of CHD events in individuals with higher serum anti‐Pg and anti‐Aa IgG antibody responses may support their use as potential biomarkers to detect and monitor at‐risk populations. However, the observed inconsistencies with the design and interpretation of immunoassays warrant standardization of the immunoassays assessing antibody responses against periodontal bacteria.

show abstract

Relationship between periodontitis and rheumatoid arthritis in Vietnamese patients

Cited by 13 publications

References 39 publications

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study

Rheumatoid arthritis serotype and synthetic disease-modifying anti-rheumatic drugs in patients with periodontitis: A case-control study

Hyaluronic acid 0.2% application enhanced periodontitis treatment in non-surgical phase

Serum antibody response against periodontal bacteria and coronary heart disease: Systematic review and meta‐analysis

Contact Info

Product

Resources

About