Relationship Between Platelet Count and In-hospital Mortality in Adult Patients With COVID-19: A Retrospective Cohort Study

Gao, Jun; Zeng, Xiaomei; Chen, Junyu; Wen, Deliang

doi:10.3389/fmed.2022.802412

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…In this study, leukocytosis, neutrophilia, lymphopenia and thrombocytopenia were more frequently seen in non-survivor patients with diabetes. Several studies (Abd El-Lateef et al, 2022;Loomba et al, 2022;Malik et al, 2021;Niu et al, 2022;Yang, Gao, et al, 2022; found lymphopenia and thrombocytopenia as independent predictors of poor outcome which is also consistent with our study. Won et al, 2022).…”

Section: Interpretation In the Context Of The Wider Literaturesupporting

confidence: 93%

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

et al. 2022

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Aim This study aimed to identify the predictors of mortality and ICU requirements in hospitalized COVID‐19 Patients with Diabetes. Design Cross‐sectional study. Methods It was a retrospective study of patients hospitalized with COVID‐19 infection from October 2020–February 2021 in four hospitals in Sylhet, Bangladesh. Logistic regression analysis was applied to explore the predictors of ICU requirement and in‐hospital mortality. Results In the whole cohort (n = 500), 11% of patients died and 24% of patients required intensive care unit (ICU) support. Non‐survivors had significantly higher prevalence of lymphopenia, thrombocytopenia and leukocytosis. Significant predictors of in‐hospital mortality were older age, neutrophil count, platelet count and admission peripheral capillary oxygen saturation (SpO2). Older age, ischemic heart disease, WBC count, D‐dimer and admission SpO2 were identified as significant predictors for ICU requirement. Patient or Public Contribution No.

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Section: Interpretation In the Context Of The Wider Literaturesupporting

confidence: 93%

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

et al. 2022

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“…The new models contain 7 confounding variables, including age, GCS score, endovascular therapy, Charlson comorbidity index, sepsis, Clipping, and sex. It was explored whether there was a curve relationship between T-lowest and in-hospital mortality using restricted cubic spline analysis 26 . We conducted interaction and stratified analyses based on GCS (< 8 and ≥ 8 scores), sex, and age (< 60 and ≥ 60 years).…”

Section: Methodsmentioning

confidence: 99%

Hypothermia on the first day of ICU admission leads to increased in-hospital mortality in patients with subarachnoid hemorrhage

Du,

Yang,

Lou

et al. 2024

Sci Rep

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The relationship between early spontaneous hypothermia and adverse clinical outcomes in patients with subarachnoid hemorrhage (SAH) has not been paid much attention. We designed this retrospective cohort study to determine this relationship by analyzing the association between the lowest body temperature (T-lowest) on the first day of ICU admission and in-hospital mortality. In this study, 550 participants with non-traumatic SAH were chosen from the Medical Information Mart for Intensive Care (MIMIC)-IV database. Multivariate Cox regression analysis showed that T-lowest was nonlinearity correlated with in-hospital mortality (HR = 0.72, 95% CI: 0.59–0.86, p < 0.001). We divided the T-lowest into quartile groups. In comparison to reference group Q1 (31.30–36.06 ℃), group Q3 (36.56–36.72 ℃) had a 50% lower risk of death in the hospital (HR: 0.5, 95% CI: 0.28–0.87, p = 0.014). We further confirmed the curve-like relationship between T-lowest and in-hospital mortality using restricted cubic splines. The mortality is lowest when the T-lowest is close to 36.5 °C, and the risk of death is increased when the temperature is lower or higher than that. Our study demonstrates that in-hospital mortality is associated with T-lowest. Patients with non-traumatic SAH are at increased risk of death if their body temperature on the first day of ICU admission is too low.

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“…The threshold effect of bicarbonate is determined using a two-piecewise linear regression model if a non-linear connection is observed. The linear model was contrasted using the log-likelihood ratio test as well ( 19 ). Interaction and stratified analyses were performed for age (<60 years and ≥ 60 years), sex, myocardial infarction, congestive heart failure, hypertension, diabetes, sepsis, endovascular aneurysm treatment, and GCS (<8 and ≥ 8 scores).…”

Section: Methodsmentioning

confidence: 99%

Relationship between baseline bicarbonate and 30-day mortality in patients with non-traumatic subarachnoid hemorrhage

Du,

Yang,

Lou

et al. 2024

Front. Neurol.

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ObjectiveThis study aimed to explore the relationship between baseline bicarbonate levels and 30-day mortality in individuals with non-traumatic subarachnoid hemorrhage (SAH).MethodsPatients with non-traumatic SAH were chosen from the Medical Information Mart for Intensive Care (MIMIC)-IV database. The relationship between baseline bicarbonate and 30-day mortality was examined using Cox regression models. Restricted cubic splines were used to test the hypothesis that there was an association between bicarbonate and mortality. With the use of Kaplan–Meier survival curve analysis, we looked deeper into the validity of these correlations. To find subgroups with differences, interaction tests were utilized.ResultsThis retrospective cohort study consisted of 521 participants in total. Bicarbonate had a negative association with death at 30 days (HR = 0.93, 95%CI: 0.88–0.98, p = 0.004). Next, we divided bicarbonate into quartile groups. In comparison to the reference group Q1 (20 mEq/L), groups Q3 (23–25 mEq/L) and Q4 (26 mEq/L) had adjusted HR values of 0.47 (95%CI: 0.27–0.82, p = 0.007) and 0.56 (95%CI: 0.31–0.99, p = 0.047). No definite conclusions can be derived from this study, since there is no obvious curve link between baseline bicarbonate and 30-day mortality. Patients’ 30-day mortality increased statistically significantly (p < 0.001, K–M analysis) in patients with low bicarbonate levels. The relationship between bicarbonate and 30-day mortality remained consistent in the stratified analysis, with no observed interactions.ConclusionFinally, 30-day mortality was negatively associated with baseline bicarbonate levels. Patients with non-traumatic SAH are more at risk of mortality if their bicarbonate levels are low.

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Relationship Between Platelet Count and In-hospital Mortality in Adult Patients With COVID-19: A Retrospective Cohort Study

Cited by 9 publications

References 31 publications

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

Predictors of mortality and ICU requirement in hospitalized COVID‐19 patients with diabetes: A multicentre study

Hypothermia on the first day of ICU admission leads to increased in-hospital mortality in patients with subarachnoid hemorrhage

Relationship between baseline bicarbonate and 30-day mortality in patients with non-traumatic subarachnoid hemorrhage

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