Relationship between stereopsis and vision-related quality of life following intravitreal ranibizumab injections for central retinal vein occlusion

Abstract

The study aimed to evaluate changes in stereopsis and vision-related quality of life (VR-QOL) in patients with central retinal vein occlusion (CRVO) following intravitreal ranibizumab injection (IVR) and investigate the relationship between stereopsis and VR-QOL. This study included 23 treatment-naïve patients with non-ischemic CRVO and 13 age-matched normal controls. Stereopsis, best-corrected visual acuity (BCVA), VR-QOL, and retinal microstructures were examined pre-treatment and 12 months post-treatment. The Titmus Stereo Test (TST) and TNO stereotest (TNO) were used to evaluate stereopsis. VR-QOL was evaluated using the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25). IVR immediately and significantly improved the TST values, TNO values, composite VFQ-25 score, BCVA, and central foveal thickness in patients with CRVO. The 12-month post-treatment TST and TNO values were significantly worse in the CRVO group compared to those in the normal group. At the baseline, the composite VFQ-25 score significantly correlated only with the TST value. Multivariate analysis revealed significant associations between the 12-month post-treatment composite VFQ-25 score and the baseline and 12-month post-treatment TNO values. In conclusion, IVR immediately improved stereopsis in CRVO, albeit below normal levels. Stereopsis (not visual acuity) was associated with pre- and post-treatment VR-QOL in patients with CRVO.

Optical coherence tomography parameters as prognostic factors for stereopsis after vitrectomy for unilateral epiretinal membrane: a cohort study

“…According to recent researches, binocular stereopsis is greatly impacted by monocular impairment in BCVA in various retinal disorders, including CRVO 27 , 28 , RRD 25 ,Macular hole 29 , and ERM 16 . Spearman correlation analysis in our results revealed a positive relationship between preoperative TST value and pre-BCVA, postoperative stereopsis and post-BCVA, as well as post-TNO value and pre-BCVA, which highlighted that is monocular visual acuity impairment closely linked to stereopsis.…”

Life Quality in Patients with Impaired Visual Acuity Undergoing Intravitreal Medication Applications

“…In addition to male-female differences in metabolism, lifestyle, and physical performance, this vast field of research has identified gender differences in response to therapeutic agents, diagnostic, and therapeutic interventions [16]. Furthermore, in the study by Okamoto et al, no differences in age and gender were observed between the groups [17].…”

“…The study by the author Korobelnik and associates showed significant functional and anatomical advantages of treatment with intravitreal drug applications in the eye. The endpoint of efficacy was patient who gained 15 or more letters in best-corrected visual acuity at week 24 of treatment, and the improvement achieved was maintained until week 52 of treatment [17].…”

Visual Functions Affecting Vision-Related Quality of Life Following Intravitreal Ranibizumab Therapy for Central Retinal Vein Occlusion

“…The advent of anti-vascular endothelial growth factor (VEGF) therapy has improved the visual prognosis of patients with CRVO-CME [ 2 , 3 ]. However, even if CME resolves after treatment, some patients may not have satisfactory visual function due to metamorphopsia [ 4 ], decreased contrast sensitivity (CS) [ 5 ], and decreased stereopsis [ 6 ].…”

“…Okamoto et al investigated stereopsis in patients with CRVO-CME after anti-VEGF therapy and reported that stereopsis improved after treatment. However, stereopsis remained worse than that in individuals without ocular disease and was associated with VR-QoL at baseline and after treatment [ 6 ]. Deramo et al reported that the best-corrected VA (BCVA) of the fellow eye was more related to VR-QOL than the VA of the affected eye in patients with CRVO-CME [ 11 ].…”