Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and thyroid hormone levels in Chinese non-occupational exposure adult males

Zhu, Pengfei; Bian, Zenghui; Xia, Yankai; Yan, Han; Qiao, Shubin; Zhao, Risheng; Jin, Nianzu; Wang, Shoulin; Peng, Yongjun; Wang, Xinru

doi:10.1016/j.chemosphere.2009.08.054

Cited by 30 publications

(16 citation statements)

References 31 publications

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“…For FT3 and FT4, no previously reported significant associations with parent PAHs in urine were found. Zhu et al (2009) found positive correlations of metabolites of FLU with TSH in Chinese unexposed males, but none of the metabolites of NAP, FLU or PYR correlated with FT3 or FT4. In vitro tests by Bekki et al (2009) showed that many PAH metabolites activate thyroid receptor beta and are associated with transthyretin, a thyroid hormone transporting protein.…”

Section: Exposure-response Associationsmentioning

confidence: 79%

Investigating unmetabolized polycyclic aromatic hydrocarbons in adolescents' urine as biomarkers of environmental exposure

et al. 2016

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Polycyclic aromatic hydrocarbons (PAHs) are of interest to human biomonitoring studies due to their carcinogenic potential. Traditionally metabolites of these compounds, like 1-hydroxypyrene, are monitored in urine, but recent methods allow the determination of the parent compounds in urine, which give additional information regarding sources and toxicity of PAHs. In order to assess the feasibility of incorporating these methods in a human biomonitoring study, the 16 USEPA parent PAHs were determined in 20 urine samples. These samples were obtained from 10 boys and 10 girls aged 14-16 years, participating in the third Flemish Environment and Health Study (Flanders, Belgium). Of these 16 parent PAHs, nine could be determined in more than 95% of the samples and three (including benzo(a)pyrene) in more than 50%. Several correlations were found between different PAHs, but not between pyrene and its metabolite 1-hydroxypyrene. Diagnostic PAH ratios in urine and air samples pointed towards combustion sources and are in line with the ratios in environmental samples. Benzo(a)pyrene, naphthalene and fluorene have the highest carcinogenic potential in our cohort, when using toxic equivalency factors. Some associations between PAH congeners and determinants of exposure were found, while fluorene and acenaphthylene were positively associated with thyroid hormone levels and benzo(a)pyrene showed a positive correlation with DNA damage by comet assay. These results confirm that parent PAHs in urine are useful as biomarkers of exposure in biomonitoring studies.

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Section: Exposure-response Associationsmentioning

confidence: 79%

Investigating unmetabolized polycyclic aromatic hydrocarbons in adolescents' urine as biomarkers of environmental exposure

et al. 2016

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“…1-and 2-Hydroxynaphthalene, which are naphthalene metabolites, and 2-hydroxyfluorene, a fluorine metabolite, were reported at 2.306, 4.047, and 2.899 ppm, respectively. 34 Exposure to PAHs is positively correlated with TSH levels.…”

Section: Discussionmentioning

confidence: 99%

“…33 Environmental exposure to PAHs was determined based on the presence of metabolites in the urine. 33,34 The pyrene metabolite 1-hydroxypyrene, was detected at 1.155 ppm. 1-and 2-Hydroxynaphthalene, which are naphthalene metabolites, and 2-hydroxyfluorene, a fluorine metabolite, were reported at 2.306, 4.047, and 2.899 ppm, respectively.…”

Section: Discussionmentioning

confidence: 99%

Changes in thyroid peroxidase activity in response to various chemicals

et al. 2012

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Thyroperoxidase (TPO) is a large heme-containing glycoprotein that catalyzes the transfer of iodine to thyroglobulin during thyroid hormone (TH) synthesis. Previously, we established an in vitro assay for TPO activity based on human recombinant TPO (hrTPO) stably transfected into human follicular thyroid carcinoma (FTC-238) cells. It is important to determine whether environmental chemicals can disrupt TPO activity because it is an important factor in the TH axis. In this study, we used our assay to examine the changes in TPO activity in response to various chemicals, including benzophenones (BPs), polycyclic aromatic hydrocarbons (PAHs), and persistent organic pollutants (POPs). Overall, BPs, PAHs, and POPs slightly altered TPO activity at low doses, as compared with the positive controls methimazole (MMI), genistein, and 2,2',4,4'-tetrahydroxy BP. Benzophenone, benzhydrol, 3-methylchloranthracene, pyrene, benzo(k)fluoranthene, benzo(e)pyrene, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and heptachlor decreased TPO activity, while 2,4-dihydroxy BP, 2,2'-dihydroxy-4-methoxy BP, and dibenzo(a,h)anthracene increased TPO activity. From these data, we can predict the disruption of TPO activity by various chemicals as a sensitive TH end point. TPO activity should be considered when enacting measures to regulate environmental exposure to thyroid-disrupting chemicals.

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“…BaP, DMBA, and 3-methylcholanthrene (3-MC) are typically the most studied. PAHs, however are not only carcinogenic, but also alter immune function, increase mixed function oxygenase (MFO) activity, disrupt endocrine homeostasis, and cause teratogenic effects (White, Kawabata, and Ladics 1994;Keith 1997;Billiard et al 2008;Zhu et al 2009). BbF, like most PAH, is not naturally found in the environment in high concentrations (Agency for Toxic Substances and Disease Registry 1995; Irwin et al 1997).…”

Section: Discussionmentioning

confidence: 98%

Alterations in immune function and CYP450 activity of adult male deer mice following exposure to either 7,12-dimethylbenz[a]anthracene or benzo[b]fluoranthene

Liu

Peden‐Adams

Knuteson

et al. 2011

Toxicological & Environmental Chemistry

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Adult male deer mice were exposed every other day for a period of 11 days to either 7,12-dimethylbenzanthracene (DMBA; CAS# 57-97-6) or benzo [b]fluoranthene (BbF; CAS# 205-99-2) (0, 0.3, 1, 3, 10, or 30 mg kg À1 ). Immune endpoints assessed were lymphocyte proliferation, macrophage pinocytosis, and the antibody plaque-forming cell (PFC) response. Cytochrome P450 (CYP450) activity was assessed using ethoxyresorufin-O-deethylase (EROD) and pentoxyresorufin-O-deethylase (PROD). Macrophage pinocytosis was not altered by either compound. Both T-and B-cell proliferations were significantly increased by DMBA at 0.3 or 1 mg kg À1 and by BbF at 10 or 30 mg kg À1 , but decreased by DMBA at 30 mg kg À1 . Sheep red blood cell (SRBC)-specific-IgM production, as measured by the PFC response, was the most striking adverse immune effect observed and was significantly suppressed compared to control at all treatment concentrations for both compounds. EROD activity was markedly induced by DMBA at 30 mg kg À1 , while BbF produced induction at 1, 10, or 30 mg kg À1 . No marked effect on PROD activity was noted following DMBA treatment, but BbF-induced PROD activity at 1, 10, or 30 mg kg À1 . Unexpectedly, four of six mice in the 30 mg DMBA kg À1 group did not survive to the end of the experiment, and one animal died in both the 3 and 10 mg kg À1 treatments. The calculated LD 50 was 20.8 mg DMBA kg À1 . The PFC response in deer mice was a more sensitive endpoint than CYP450 activity, suggesting that utilization of CYP450 endpoints in risk assessment without assessment of immune function, specifically antibody production, might possibly underestimate the risk to wild rodents environmentally exposed to polycyclic aromatic hydrocarbons.

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Relationship between urinary metabolites of polycyclic aromatic hydrocarbons and thyroid hormone levels in Chinese non-occupational exposure adult males

Cited by 30 publications

References 31 publications

Investigating unmetabolized polycyclic aromatic hydrocarbons in adolescents' urine as biomarkers of environmental exposure

Investigating unmetabolized polycyclic aromatic hydrocarbons in adolescents' urine as biomarkers of environmental exposure

Changes in thyroid peroxidase activity in response to various chemicals

Alterations in immune function and CYP450 activity of adult male deer mice following exposure to either 7,12-dimethylbenz[a]anthracene or benzo[b]fluoranthene

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