Relationship between zinc-related nutritional status and the progression of multiple sclerosis

Castro, A.J. Ramiro de; Albuquerque, Larissa da Silva; Melo, Maria Luísa Pereira de; D'Almeida, José Artur Costa; Braga, Ribanna Aparecida Marques; Assis, Renata Carmo de; Marreiro, Dilina do Nascimento; Matos, Wladiana O.; Maia, Carla Soraya Costa

doi:10.1016/j.msard.2022.104063

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Regarding zinc, the alterations in blood zinc concentration in pwMS are still conflicting: no alteration [42] vs. reduced concentration [15] compared to controls. Despite the inconsistencies in blood zinc concentration, it is important to note that alterations in zinc levels can have detrimental effects on neuronal cells, with both elevated and reduced levels being potentially neurotoxic and contributing to neurodegeneration [35].…”

Section: Discussionmentioning

confidence: 99%

The Blood Concentration of Metallic Nanoparticles Is Related to Cognitive Performance in People with Multiple Sclerosis: An Exploratory Analysis

Oliveira¹,

Santinelli

Lisboa‐Filho³

et al. 2023

Biomedicines

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The imbalance in the concentration of metallic nanoparticles has been demonstrated to play an important role in multiple sclerosis (MS), which may impact cognition. Biomarkers are needed to provide insights into the pathogenesis and diagnosis of MS. They can be used to gain a better understanding of cognitive decline in people with MS (pwMS). In this study, we investigated the relationship between the blood concentration of metallic nanoparticles (blood nanoparticles) and cognitive performance in pwMS. First, four mL blood samples, clinical characteristics, and cognitive performance were obtained from 21 pwMS. All participants had relapse–remitting MS, with a score of ≤4.5 points in the expanded disability status scale. They were relapse-free in the three previous months from the day of collection and had no orthopedic, muscular, cardiac, and cerebellar diseases. We quantified the following metallic nanoparticles: aluminum, chromium, copper, iron, magnesium, nickel, zinc, and total concentration. Cognitive performance was measured by mini-mental state examination (MMSE) and the symbol digit modalities test (SDMT). Pearson’s and Spearman’s correlation coefficients and stepwise linear regression were calculated to assess the relationship between cognitive performance and blood nanoparticles. We found that better performance in SDMT and MMSE was related to higher total blood nanoparticles (r = 0.40; p < 0.05). Also, better performance in cognitive processing speed and attention (SDMT) and mental state (MMSE) were related to higher blood iron (r = 0.44; p < 0.03) and zinc concentrations (r = 0.41; p < 0.05), respectively. The other metallic nanoparticles (aluminum, chromium, copper, magnesium, and nickel) did not show a significant relationship with the cognitive parameters (p > 0.05). Linear regression estimated a significant association between blood iron concentration and SDMT performance. In conclusion, blood nanoparticles are related to cognitive performance in pwMS. Our findings suggest that the blood concentration of metallic nanoparticles, particularly the iron concentration, is a promising biomarker for monitoring cognitive impairment in pwMS.

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Section: Discussionmentioning

confidence: 99%

The Blood Concentration of Metallic Nanoparticles Is Related to Cognitive Performance in People with Multiple Sclerosis: An Exploratory Analysis

Oliveira¹,

Santinelli

Lisboa‐Filho³

et al. 2023

Biomedicines

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“…Accumulating evidence suggests that the disruption of Zn 2+ homeostasis is associated with the pathogenesis of MS. Several studies have shown that MS patients have both decreased serum Zn 2+ levels [202,221,222] and reduced Zn 2+ intake [223], while others showed no significant differences in serum Zn 2+ level between healthy controls and MS patients [224], or even higher plasma Zn 2+ concentration in MS patients [225]. However, two recent meta-analysis studies revealed lower circulating Zn 2+ levels in MS [66,67].…”

Section: Zn 2+ and Multiple Sclerosismentioning

confidence: 99%

Zinc and Central Nervous System Disorders

2023

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Zinc (Zn2+) is the second most abundant necessary trace element in the human body, exerting a critical role in many physiological processes such as cellular proliferation, transcription, apoptosis, growth, immunity, and wound healing. It is an essential catalyst ion for many enzymes and transcription factors. The maintenance of Zn2+ homeostasis is essential for the central nervous system, in which Zn2+ is abundantly distributed and accumulates in presynaptic vesicles. Synaptic Zn2+ is necessary for neural transmission, playing a pivotal role in neurogenesis, cognition, memory, and learning. Emerging data suggest that disruption of Zn2+ homeostasis is associated with several central nervous system disorders including Alzheimer’s disease, depression, Parkinson’s disease, multiple sclerosis, schizophrenia, epilepsy, and traumatic brain injury. Here, we reviewed the correlation between Zn2+ and these central nervous system disorders. The potential mechanisms were also included. We hope that this review can provide new clues for the prevention and treatment of nervous system disorders.

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The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review

Salekzamani,

Baharomid,

Pakkhesal

et al. 2024

J Evid Based Complementary Altern Med

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Background Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. Caffeine, as the most widely consumed psychoactive substance, has been suggested to have potential effects on the clinical course and disability levels of MS patients. This study aimed to review the current evidence on the effects of coffee/caffeine in patients with MS. Methods This study followed the Joanna Briggs Institute (JBI) Manual for Evidence Synthesis and PRISMA 2020 statement. Clinical evidence regarding the effects of caffeine/coffee in MS patients was considered. A systematic search was performed in PubMed, Scopus, Web of Science, and Embase in October 2023, and updated via handsearching in March 2024. JBI's critical appraisal tools were utilized to scrutinize the risk of bias. Results Out of 297 screened records, eight studies were eventually found to meet our inclusion criteria. The sample size of the studies varied between 12 and 1372 and the study designs were retrospective cohort, RCT, single-blind crossover trial, single-arm pilot study (each one study), and cross-sectional (four studies). No significant association between the level of disability and coffee/caffeine intake has been reported, although it was reported to be associated with cognitive improvements. Discussion Evidence indicates an association between coffee/caffeine consumption, and improved cognitive outcomes in patients with MS, while there is no considerable relationship with the disease disability. Considering the limitations of the evidence, such as the small number of studies, and great diversity in study designs, the findings of this study should translate to clinical practice with caution.

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Relationship between zinc-related nutritional status and the progression of multiple sclerosis

Cited by 4 publications

References 27 publications

The Blood Concentration of Metallic Nanoparticles Is Related to Cognitive Performance in People with Multiple Sclerosis: An Exploratory Analysis

The Blood Concentration of Metallic Nanoparticles Is Related to Cognitive Performance in People with Multiple Sclerosis: An Exploratory Analysis

Zinc and Central Nervous System Disorders

The Effects of Coffee/Caffeine in Patients with Multiple Sclerosis; A Systematic Review

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