Relationship of Epilepsy and Sleep

Lüders, Hans

doi:10.1016/b978-012216770-6/50022-6

Cited by 9 publications

(8 citation statements)

References 48 publications

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“…interictal episodes) may affect sleep, and sleep spindles in particular (Dinner and Lüders, 2001; Steriade, 2005). Therefore, it was imperative to confirm that our results could be generalized to the healthy population, and multiple observations strongly suggest that this is the case.…”

Section: Resultsmentioning

confidence: 99%

Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings

Andrillon

Nir

Staba³

et al. 2011

J. Neurosci.

459

475

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Sleep spindles are an electroencephalographic (EEG) hallmark of non-rapid eye movement (NREM) sleep and are believed to mediate many sleep-related functions, from memory consolidation to cortical development. Spindles differ in location, frequency, and association with slow waves, but whether this heterogeneity may reflect different physiological processes and potentially serve different functional roles remains unclear. Here we utilized a unique opportunity to record intracranial depth EEG and single-unit activity in multiple brain regions of neurosurgical patients to better characterize spindle activity in human sleep. We find that spindles occur across multiple neocortical regions, and less frequently also in the parahippocampal gyrus and hippocampus. Most spindles are spatially restricted to specific brain regions. In addition, spindle frequency is topographically organized with a sharp transition around the supplementary motor area between fast (13-15Hz) centroparietal spindles often occurring with slow wave up-states, and slow (9-12Hz) frontal spindles occurring 200ms later on average. Spindle variability across regions may reflect the underlying thalamocortical projections. We also find that during individual spindles, frequency decreases within and between regions. In addition, deeper sleep is associated with a reduction in spindle occurrence and spindle frequency. Frequency changes between regions, during individual spindles, and across sleep may reflect the same phenomenon, the underlying level of thalamocortical hyperpolarization. Finally, during spindles neuronal firing rates are not consistently modulated, although some neurons exhibit phase-locked discharges. Overall, anatomical considerations can account well for regional spindle characteristics, while variable hyperpolarization levels can explain differences in spindle frequency.

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Section: Resultsmentioning

confidence: 99%

Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings

Andrillon

Nir

Staba³

et al. 2011

J. Neurosci.

459

475

View full text Add to dashboard Cite

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“…Our data were recorded in medicated epilepsy patients in whom abnormal events during seizure-free periods may affect brain activity in slow wave sleep (Dinner and Lüders, 2001). Inter-ictal epileptiform activity, as well as antiepileptic drugs (AEDs) and their adjustments could affect sleep in general, and the nature of slow waves in particular.…”

Section: Discussionmentioning

confidence: 99%

Regional Slow Waves and Spindles in Human Sleep

Nir

Staba

Andrillon

et al. 2011

Neuron

862

908

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SUMMARY The most prominent EEG events in sleep are slow waves, reflecting a slow (<1 Hz) oscillation between up and down states in cortical neurons. It is unknown whether slow oscillations are synchronous across the majority or the minority of brain regions—are they a global or local phenomenon? To examine this, we recorded simultaneously scalp EEG, intracerebral EEG, and unit firing in multiple brain regions of neurosurgical patients. We find that most sleep slow waves and the underlying active and inactive neuronal states occur locally. Thus, especially in late sleep, some regions can be active while others are silent. We also find that slow waves can propagate, usually from medial prefrontal cortex to the medial temporal lobe and hippocampus. Sleep spindles, the other hallmark of NREM sleep EEG, are likewise predominantly local. Thus, intracerebral communication during sleep is constrained because slow and spindle oscillations often occur out-of-phase in different brain regions.

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“…NREM uykusu sırasında çok daha sık görülen bu nö-betler uyanıkken düşme ataklarına yol açar. [16] Epilepsinin Uyku Üzerine Etkisi Hem erişkinlerde hem de çocuklarda epilepsinin uyku üze-rindeki etkisi belirgindir. Epilepsili hastalarda uykuya dalma zorluğu, uykuya başladıktan sonra sık uyanmaların olması ve gün içinde aşırı uykululuk sık karşılaşılan şikâyetlerdir.…”

Section: Epilepsi Nöbet Tiplerinin Uyku Evreleri Ve Zamanı Ile İlişkiunclassified

Sleep and Epilepsy

Recep¹,

Altindag²

2014

Epilepsi

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ÖzetÇoğu epilepsi sendromunun klinik ve EEG bulgularının uyku ile ilişkisi çok iyi bilinmektedir. Epilepsilerin uyku ile ilişkili olduğu bilinen nöronal yolakların hastalığı olduğu düşünülmektedir. Diğer bir yönden de epilepsili hastalarda sağlıklı kontrollere göre daha fazla oranda uyku bozuklukları bildirilmiştir. Dahası yetersiz uyku kalitesi nöbet kontrolünü bozmakta ve bir kısır döngü oluşmaktadır. Ayrıca antiepileptik ilaçların da uyku yapısı üzerine etkisi mevcuttur. Bu derlemede amacımız ilgili literatür ışığında uyku ve epilepsi arasındaki kompleks ilişkiyi gözden geçirmektir.Anahtar sözcükler: EEG; epilepsi; uyku. SummaryIt is well known that clinical and EEG manifestations of many epilepsy syndromes are related to sleep-and-waking cycles. Epilepsies are thought as disorders reflecting abnormalities in neuronal networks underlying sleep process. Patients with epilepsy, on the other hand, are generally reported to have poor sleep quality when compared with healthy controls. Furthermore, poor sleep quality or sleep-deprivation may worsen seizure control and set a vicious cycle. Anti-epileptic drugs may also affect sleep architecture. Here, we aim to review the complex relationship of sleep and epilepsy in the light of relevant literature.

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Relationship of Epilepsy and Sleep

Cited by 9 publications

References 48 publications

Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings

Sleep Spindles in Humans: Insights from Intracranial EEG and Unit Recordings

Regional Slow Waves and Spindles in Human Sleep

Sleep and Epilepsy

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