Relationship of Nutritional Status, Inflammation, and Serum Albumin Levels During Acute Illness: A Prospective Study

Abstract

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Evaluation of the nutritional status in patients with COVID-19

“…( 1 , 16 ) Inflammation and malnutrition always exist concomitantly as malnutrition can enhance the susceptibility to infections; Meanwhile, infections further promote malnutrition via increased demand for nutrients and decreased appetite. ( 17 ) In one study by Eckart et al ( 18 ) enrolling 2,465 patients, elevated serum CRP concentration was related to low albumin levels, suggesting increased elevated inflammatory parameters was independently associated with hypoalbuminemia. In this study, the patients with moderate-severe malnutrition had higher counts of white blood cell and neutrophil and elevated serum levels of CRP, suggesting an active inflammatory state.…”

Glasgow prognostic score is a better predictor of the long-term survival in patients with gastric cancer, compared to the modified Glasgow prognostic score or high-sensitivity modified Glasgow prognostic score

“…CRP, a reliable marker of systemic inflammation, reflects cell-mediated immunity associated with poor outcomes in several cancers [3,4]. Additionally, serum albumin levels are a leading indicator of nutritional status and serum albumin levels likely decrease secondarily to a systemic inflammatory response [1,2]. Therefore, nutritional status and inflammatory response should be considered in conjunction when assessing the prognoses of cancer patients.…”

“…Nutrition and inflammation are closely related; inflammation induces malnutrition by increasing catabolism and impairing nutrient absorption, and conversely, malnutrition promotes the severity of inflammation [1,2].…”

A Cohort Study of Liver Involvement in Patients With Adult-Onset Still's Disease: Prevalence, Characteristics and Impact on Prognosis

“…In addition, we first discovered that the levels of preAlb and Alb in patients with AOSD were negatively associated with multiple well-known disease activity biomarkers, which reflect disease activity. Although the reduced levels of preAlb and Alb might result from malnutrition, the systemic inflammation can also suppress the production of preAlb and Alb, as part of the acute phase response (29)(30)(31)(32). The decreased levels of these two proteins were also described in rheumatoid arthritis (RA), and the Alb levels were found to reflect disease activity (33,34).…”