Relationship of serum brain-derived neurotrophic factor level with other markers of disease severity in patients with atopic dermatitis

Namura, Kenji; Hasegawa, Goji; Egawa, Masato; Matsumoto, Tadasu; Kobayashi, Riko; Yano, Tadashi; Katoh, Norito; Kishimoto, Saburo; Ohta, Mitsuhiro; Obayashi, Hiroshi; Ose, Hiroyuki; Fukui, Michiaki; Nakamura, Naoto; Yoshikawa, Toshikazu

doi:10.1016/j.clim.2006.10.011

Cited by 33 publications

(23 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of this study are in contrast to the regulation of the neurotrophin BDNF which has repeatedly been shown to be increased in AD [14, 15]. Thus, the present study points to a differential regulation of these structurally related mediators in this disease.…”

Section: Discussioncontrasting

confidence: 54%

“…Also in psoriasis, a second very common chronic inflammatory skin disease, NGF was shown to be relevantly involved in its immunopathophysiology [for a review, see Botchkarev et al [8]]. In patients with AD, increased levels of serum NGF [11, 13] but also of another neurotrophin, the brain-derived neurotrophic factor (BDNF), were reported [14, 15]. However, in a previous study, we did not find a positive relation between NGF serum levels in AD patients compared to healthy controls [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Schulte‐Herbrüggen

Fölster‐Holst

Elstermann

et al. 2007

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Nerve growth factor (NGF) is known to act as a potent mediator in neuroinflammatory processes. Recent studies point to a role of NGF in the skin pathophysiology of atopic dermatitis (AD) and psoriasis. Hereby, NGF was found to interact with the major cellular components (mast cells and eosinophils) of both skin diseases. Objectives: In order to investigate NGF serum levels as a possible clinical marker of disease activity and immunological status, we determined serum NGF, eosinophil cationic protein (ECP), total IgE and score of AD (SCORAD) in 57 patients with AD as well as NGF and the psoriasis area and severity index (PASI) in 17 patients with psoriasis. Fifty healthy subjects served as controls. Methods: We used a highly sensitive improved fluorometric two-site ELISA system for serum NGF detection. IgE and ECP were measured by CAP-FEIA and radioimmunoassay. Results: We did not find a significant correlation between NGF and either ECP, total IgE, or severity of disease assessed by SCORAD. Also in patients with psoriasis, there was no significant correlation with disease activity determined by PASI. Conclusion: Even though there is increasing evidence showing NGF to be involved in the local inflammatory pathophysiology of AD within skin lesions, our findings suggest that NGF systemic serum concentration is not a suitable parameter to estimate the clinical or immunological status of AD or psoriasis patients. This result is inconsistent with some previous studies showing a positive correlation of serum NGF with AD severity, which might be, for example, due to the fact that the present results are corrected for unspecific binding.

show abstract

Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Schulte‐Herbrüggen

Fölster‐Holst

Elstermann

et al. 2007

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…39 It is likely that NGF detected in plasma is mainly released from inflammatory cells, 8 while neurons, vascular endothelial cells, and other sources may dominate concerning BDNF found in plasma. 40,41 From a functional point of view, it is of interest to note that neurotrophins are considered to have trophic and protective roles (for references, see Introduction). Overexpression of NGF can be related to a modulation of the inflammatory response 42 and NGF can have wound-healing effects.…”

Section: Neurotrophins In Plasma and Mucosamentioning

confidence: 99%

New aspects concerning ulcerative colitis and colonic carcinoma: Analysis of levels of neuropeptides, neurotrophins, and TNFalpha/TNFreceptor in plasma and mucosa in parallel with histological evaluation of the intestine

Johansson

Jönsson

Norrgård

et al. 2008

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

“…Studies have suggested that NGF and BDNF play important roles in the pathogenesis of atopic dermatitis (AD). Serum levels of NGF and BDNF are increased, providing a useful indicator of disease activity in patients with AD (5,(11)(12)(13).…”

mentioning

confidence: 99%

Association of Nerve Growth Factor, Chemokine (C-C motif) Ligands and Immunoglobulin E with Pruritus in Cutaneous T-cell Lymphoma

Suga¹,

Sugaya²,

Miyagaki³

et al. 2013

Acta Derm Venerol

View full text Add to dashboard Cite

Many patients with cutaneous T-cell lymphoma (CTCL) experience severe pruritus. This study evaluated serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) in patients with CTCL. Although serum NGF and BDNF levels in patients with CTCL were not significantly higher than in healthy controls, serum NGF levels in patients with Sézary syndrome were higher than in those with mycosis fungoides and in healthy controls. Enhanced NGF expression by keratinocytes and increased dermal nerve fibres were detected in lesional skin of subjects with Sézary syndrome. Correlations between pruritus in CTCL and serum levels of NGF, BDNF, chemokine (C-C motif) ligand 1 (CCL1), CCL17, CCL26, CCL27, lactate dehydrogenase (LDH), IgE, and soluble interleukin-2 receptor were analysed. Serum CCL1, CCL26, LDH, and IgE levels correlated with pruritus in patients with CTCL. NGF may be associated with increased dermal nerve fibres and pruritus in Sézary syndrome, and CCL1, CCL26, and IgE may be associated with pruritus in CTCL.

show abstract

Relationship of serum brain-derived neurotrophic factor level with other markers of disease severity in patients with atopic dermatitis

Cited by 33 publications

References 42 publications

Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

Clinical Relevance of Nerve Growth Factor Serum Levels in Patients with Atopic Dermatitis and Psoriasis

New aspects concerning ulcerative colitis and colonic carcinoma: Analysis of levels of neuropeptides, neurotrophins, and TNFalpha/TNFreceptor in plasma and mucosa in parallel with histological evaluation of the intestine

Association of Nerve Growth Factor, Chemokine (C-C motif) Ligands and Immunoglobulin E with Pruritus in Cutaneous T-cell Lymphoma

Contact Info

Product

Resources

About